Navigation Links
Aegera Therapeutics Initiates A Randomized Phase 2 Combination Study of AEG35156 for 1st Line Treatment of Non-Small Cell Lung Cancer
Date:1/8/2009

MONTREAL, Jan. 8 /PRNewswire/ - Aegera Therapeutics Inc. announced today the dosing of the first patient in a randomized Phase 2 study of AEG35156, their targeted antisense therapeutic in mid-stage development for multiple oncology indications.

The study, entitled "A Phase 2, Multicenter, Open-Label, Randomized Study of the X-Linked Inhibitor of Apoptosis (XIAP) Antisense AEG35156 Given In Combination With Carboplatin/Paclitaxel or the Combination of Carboplatin/Paclitaxel Alone In Patients With Advanced Non Small Cell Lung Cancer" is being conducted in the United States in collaboration with U.S. Oncology and additional sites will be opened in Canada. The Principal Investigator of this study is Dr. Robert M. Jotte, of the Rocky Mountain Cancer Center in Denver, Colorado.

The primary objective of this study is to compare the efficacy of the standard of care for this patient population to the standard of care in combination with AEG35156. Recruitment for this trial is expected to be completed prior to the end of 2009.

"Preliminary evidence of activity was observed in the Phase 1 portion of this study and encouraged us to amend the clinical protocol to provide for a control arm for the Phase 2 portion of the study" stated Dr. Jacques Jolivet, Senior Vice-President of Clinical Development of Aegera.

"Our clinical program around AEG35156 continues to accelerate and expand as we seek to move this therapeutic forward to more advanced stages of clinical development," added Aegera's President and Chief Executive Officer, Dr. Michael J. Berendt. "The initiation of this randomized Phase 2 study in lung cancer follows very shortly after our publication of positive clinical data from our Phase 1/2 study in AML at the recent ASH conference in San Francisco and represents the first of multiple new clinical trials for this innovative therapy that we hope to announce over the course of 2009."

About AEG35156

Ca
'/>"/>

SOURCE AEGERA THERAPEUTICS INC.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2

Related biology technology :

1. Aegera Therapeutics phase 1/2 clinical trial results selected for oral presentation at 2008 ASH Annual Meeting
2. Aegera Therapeutics collaboration with Human Genome Sciences leads to the initiation of a Phase 1 clinical trial with lead IAP inhibitor HGS1029 and receipt of first milestone payment
3. Aegera Therapeutics welcomes two experienced executives to its board of directors
4. Aegera initiates Phase 1 clinical trial of AEG33773 - A small molecule in development for diabetic neuropathic pain
5. Human Genome Sciences and Aegera Therapeutics Announce Licensing and Collaboration Agreement on Novel Anti-Cancer Drugs
6. Amicus Therapeutics Adds Sol J. Barer, Ph.D. to Board of Directors
7. Cell Therapeutics Announces Receipt of NASDAQ Panel Decision to Transfer to NASDAQ Capital Market
8. Horizon Therapeutics Announces Senior Management Appointments
9. Nektar Therapeutics President and CEO, Howard W. Robin, to Present at the 27th Annual J.P. Morgan Healthcare Conference in San Francisco
10. Orexigen(R) Therapeutics Issued a Key Fourth U.S. Patent on Contrave(R)
11. Cornerstone Therapeutics Provides Update on Integration Activities and Issues 2008 Revenue Guidance
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... , July 10, 2014 Research ... addition of the "International Photonic Integrated Circuit ... Forecasts to 2019" report to their offering. ... The concept of photonic integration traces its ... century. The promise of photonic integration went unexplored ...
(Date:7/10/2014)... University of Adelaide research may help in the fight ... can detect tiny quantities of explosives with the use ... the journal Sensors and Actuators B: Chemical , ... can detect explosives in concentrations as low as 6.3 ... of only a few minutes. , "Traditionally explosives detection ...
(Date:7/10/2014)... been extremely challenging because there are many genetic variants ... disease. Now investigators reporting in the July 3rd issue ... describe a strategy that may help reveal how ... or environmental exposures to affect the development of the ... may predispose individuals to schizophrenia. , The work ...
(Date:7/10/2014)... down forever. Nanophysics makes sure of that. Mechanics researchers at ... in Physical Review E . Knowledge that can be ... to be able to sit still forever, and walk around ... will soon be able to buy smart new fasteners that ... fact is, sooner or later the grip is lost, no ...
Breaking Biology Technology:International Photonic Integrated Circuit (Monolithic Integration, Hybrid Integration, Module Integration) Market - Forecasts to 2019 2Detecting trace amounts of explosives with light 2New strategy could uncover genes at the root of psychiatric illnesses 2Even geckos can lose their grip 2
... June 20, 2011 The complete renovation of half ... Roche campus in Nutley, N.J. has earned the company ... from the U.S. Green Building Council (USGBC). LEED certification ... and constructing the world,s greenest, most energy efficient, and ...
... June 20, 2011 Reportlinker.com announces that ... in its catalogue: The ... http://www.reportlinker.com/p0558644/The-Cancer-Market-Outlook-to-2016.html?utm_source=prnewswire&utm_medium=pr&utm_campaign=Pathology ... market is becoming increasingly competitive, with two ...
... of graphitic carbon, has the potential to make consumer ... and the shrinking scale of electronics, also make graphene ... scale. In September 2010, a UCLA ... these difficulties and were able to fabricate graphene transistors ...
Cached Biology Technology:Roche Building Awarded LEED® Gold Certification 2Roche Building Awarded LEED® Gold Certification 3Reportlinker Adds The Cancer Market Outlook to 2016 2Reportlinker Adds The Cancer Market Outlook to 2016 3Reportlinker Adds The Cancer Market Outlook to 2016 4Reportlinker Adds The Cancer Market Outlook to 2016 5UCLA team reports scalable fabrication of self-aligned graphene transistors, circuits 2
(Date:7/10/2014)... 2014 NXT-ID, Inc., (OTCQB: NXTD) a biometric authentication company focused ... Gino Pereira was interviewed on July 1 st ... Florida . Mr. Pereira discusses the company,s next generation ... and how the Wocket™ aims to replace a traditional wallet ... Cedric Harris tells Gino he has never heard of ...
(Date:7/10/2014)... , July 8, 2014 ... won a new design win (DW). An Asian OEM has ... for mass production start in August 2014.   ... smartphone OEM, which has a planned date for start of ... initial ramp order of SEK 5M, for delivery in the ...
(Date:7/10/2014)... An international team ... step of photosynthesis in action for the first time. The ... used the world,s most powerful X-ray flashlight at the US ... molecular complex called photosystem II as it splits water into ... earth,s atmosphere. The researchers report their results in the scientific ...
Breaking Biology News(10 mins):Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 2Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 3Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 4FPC Wins DW and Initial Ramp Order for FPC1021 Touch Sensor for Flagship Smartphone from Asian OEM 2Scientists watch photosynthesis in action 2Scientists watch photosynthesis in action 3
... collaboration with the Technical University of Braunschweig (TUBS), Germany ... autonomous unmanned aerial vehicles (UAVs) in Antarctica. This is ... in the Antarctic and the successful flights open up ... the harshest and remotest environment on Earth. Dr ...
... study, researchers taking advantage of improvements in satellite sensor ... of pollution from East Asian forest fires, urban exhaust, ... North America. China, the worlds most populated country, ... urban areas, and considerable expansion in automobile use over ...
... Human diseases and social networks would seem to ... of these two lies a network,communities within the ... In a recent paper in Physical Review E ... computer science and engineering and of genetics, and ...
Cached Biology News:Unmanned aerial vehicles mark robotic first for British Antarctic Survey 2NASA satellite measures pollution from east Asia to North America 2NASA satellite measures pollution from east Asia to North America 3Algorithm finds the network -- for genes or the Internet 2Algorithm finds the network -- for genes or the Internet 3
... 50ml PYREX Delong style shaker flasks have ... greater agitation of solutions to improve oxygen ... or reciprocating shakers. The long neck reduces ... closures. Their uniform wall thickness provides the ...
... Analysis of large numbers of samples may be ... system, which requires minimum operator attention. ... PowerStream software and interface CE 4900. The ... operates in Windows XP and Windows 98 and ...
... cultured in Minimum Essential Medium (Eagle) with 2 ... of growth. In order to keep the ... in acetone-methanol. The cells are arrayed on ... each wells surface specifically treated to enhance cellular ...
Mouse polyclonal antibody to REXO4 - XPMC2 prevents mitotic catastrophe 2 homolog (Xenopus laevis)...
Biology Products: