Navigation Links
Aegera Therapeutics Initiates A Randomized Phase 2 Combination Study of AEG35156 for 1st Line Treatment of Non-Small Cell Lung Cancer
Date:1/8/2009

MONTREAL, Jan. 8 /PRNewswire/ - Aegera Therapeutics Inc. announced today the dosing of the first patient in a randomized Phase 2 study of AEG35156, their targeted antisense therapeutic in mid-stage development for multiple oncology indications.

The study, entitled "A Phase 2, Multicenter, Open-Label, Randomized Study of the X-Linked Inhibitor of Apoptosis (XIAP) Antisense AEG35156 Given In Combination With Carboplatin/Paclitaxel or the Combination of Carboplatin/Paclitaxel Alone In Patients With Advanced Non Small Cell Lung Cancer" is being conducted in the United States in collaboration with U.S. Oncology and additional sites will be opened in Canada. The Principal Investigator of this study is Dr. Robert M. Jotte, of the Rocky Mountain Cancer Center in Denver, Colorado.

The primary objective of this study is to compare the efficacy of the standard of care for this patient population to the standard of care in combination with AEG35156. Recruitment for this trial is expected to be completed prior to the end of 2009.

"Preliminary evidence of activity was observed in the Phase 1 portion of this study and encouraged us to amend the clinical protocol to provide for a control arm for the Phase 2 portion of the study" stated Dr. Jacques Jolivet, Senior Vice-President of Clinical Development of Aegera.

"Our clinical program around AEG35156 continues to accelerate and expand as we seek to move this therapeutic forward to more advanced stages of clinical development," added Aegera's President and Chief Executive Officer, Dr. Michael J. Berendt. "The initiation of this randomized Phase 2 study in lung cancer follows very shortly after our publication of positive clinical data from our Phase 1/2 study in AML at the recent ASH conference in San Francisco and represents the first of multiple new clinical trials for this innovative therapy that we hope to announce over the course of 2009."

About AEG35156

Ca
'/>"/>

SOURCE AEGERA THERAPEUTICS INC.
Copyright©2009 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2

Related biology technology :

1. Aegera Therapeutics phase 1/2 clinical trial results selected for oral presentation at 2008 ASH Annual Meeting
2. Aegera Therapeutics collaboration with Human Genome Sciences leads to the initiation of a Phase 1 clinical trial with lead IAP inhibitor HGS1029 and receipt of first milestone payment
3. Aegera Therapeutics welcomes two experienced executives to its board of directors
4. Aegera initiates Phase 1 clinical trial of AEG33773 - A small molecule in development for diabetic neuropathic pain
5. Human Genome Sciences and Aegera Therapeutics Announce Licensing and Collaboration Agreement on Novel Anti-Cancer Drugs
6. Amicus Therapeutics Adds Sol J. Barer, Ph.D. to Board of Directors
7. Cell Therapeutics Announces Receipt of NASDAQ Panel Decision to Transfer to NASDAQ Capital Market
8. Horizon Therapeutics Announces Senior Management Appointments
9. Nektar Therapeutics President and CEO, Howard W. Robin, to Present at the 27th Annual J.P. Morgan Healthcare Conference in San Francisco
10. Orexigen(R) Therapeutics Issued a Key Fourth U.S. Patent on Contrave(R)
11. Cornerstone Therapeutics Provides Update on Integration Activities and Issues 2008 Revenue Guidance

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/9/2009)...tria, November 9 For more than 20 ...king on the development of a,Brain-Computer Interf...between the brain and a computer. Such a system en... or to control devices in their environment just b...ents have been supervised by,the researchers thems...
(Date:11/9/2009)... CEL-SCI Corporation (NYS... Rosenthal, Professor of Immunology and Microbiolo...dicine and Pharmacy, reported on work conducted in...inic and CEL-SCI on CEL-SCI,s LEAPS vaccine techno...ccine: "All Things Considered" Conference in Cryst...
(Date:11/9/2009)... 9 Following the provision of clin...dministration (FDA), privately,owned UK company Da...ational.com ) has been informed that its innovativ...ded an Orphan-Drug,designation for the treatment o...ALS, also known as Lou Gehrig,s disease, is the mo...
(Date:11/7/2009)...v. 7, Research projects in the are...s this evening, as Tim Kunisky of Livingston, NJ a...of Audubon, PA received the highest honors at the ... in Math, Science & Technology, the nation,s p...ttp://www.newscom.com/cgi-bin/prnh/20070904/SIEMEN...
Breaking Biology Technology:intendiX - Communication by Thoughts: First Patient-Ready System on the Market 2CEL-SCI Collaborators Present Data Suggesting That LEAPS Technology Has Ability to Modify Immune Response 2CEL-SCI Collaborators Present Data Suggesting That LEAPS Technology Has Ability to Modify Immune Response 3Mathematics and Biochemistry Research Earn Top Prize at Nation's Premier High School Science Competition 2Mathematics and Biochemistry Research Earn Top Prize at Nation's Premier High School Science Competition 3Mathematics and Biochemistry Research Earn Top Prize at Nation's Premier High School Science Competition 4Mathematics and Biochemistry Research Earn Top Prize at Nation's Premier High School Science Competition 5Mathematics and Biochemistry Research Earn Top Prize at Nation's Premier High School Science Competition 6
...aining is discussed with small companies and start...sion phase. Training should be the cornerstone of ...sit Microsoft, Hewlett-Packard, IBM, Cisco Systems...mpanies. , ,The world of technology moves so quic...st! As new computer programming languages are deve...
...shadow of the new Network222 development in downto...ebrand sermons on everything from the apocalypse t...developers of Network222 are preaching a sunnier...h innovation. And theyve got just the temple for i...ready home to several companies, is a $12 million ...
... Company recently expressed concern to Department ...PAA privacy rule may impede clinical research tria...with requests to review and approve thousands of p...formation, according to a letter from Stan Crosley...Lilly. , ,In a response letter, Richard Campanell...
Other Biology Technology:The Big Differentiator, Training! 2Wired to the Max: Network 222 2Wired to the Max: Network 222 3Wired to the Max: Network 222 4
(Date:11/4/2009)...c corridors in the cities of Long Beach and Rivers...f preventable childhood asthma, and the true impac...se has likely been underestimated, according to re... (USC). , The study, which appears in an online... , estimated that nine percent of all childhood as...
(Date:11/4/2009)...e laboratory that deciphered the DNA codes, or gen...nt shark, has joined The Genome 10K Project, an in...ry of DNA sequences on 10,000 species of animals f...currently can not be achieved. , Participating i...lished in the Nov. 5, 2009 issue of the Journal o...
(Date:11/4/2009)... N.J., Oct. 20 Quest Dia...eading provider of diagnostic testing, information...r ended September 30, 2009, income from continuing...uted share, from $160 million, or $0.81 per dilute...hird quarter results were reduced by a $0.03 per s...
Breaking Biology News(10 mins):USC study finds big air pollution impacts on local communities 2Singapore scientists join international study of 10,000 vertebrates' genomes 2Quest Diagnostics Reports Strong Performance in Third Quarter 2009 2Quest Diagnostics Reports Strong Performance in Third Quarter 2009 3Quest Diagnostics Reports Strong Performance in Third Quarter 2009 4Quest Diagnostics Reports Strong Performance in Third Quarter 2009 5Quest Diagnostics Reports Strong Performance in Third Quarter 2009 6Quest Diagnostics Reports Strong Performance in Third Quarter 2009 7Quest Diagnostics Reports Strong Performance in Third Quarter 2009 8Quest Diagnostics Reports Strong Performance in Third Quarter 2009 9Quest Diagnostics Reports Strong Performance in Third Quarter 2009 10Quest Diagnostics Reports Strong Performance in Third Quarter 2009 11Quest Diagnostics Reports Strong Performance in Third Quarter 2009 12Quest Diagnostics Reports Strong Performance in Third Quarter 2009 13Quest Diagnostics Reports Strong Performance in Third Quarter 2009 14Quest Diagnostics Reports Strong Performance in Third Quarter 2009 15Quest Diagnostics Reports Strong Performance in Third Quarter 2009 16Quest Diagnostics Reports Strong Performance in Third Quarter 2009 17UM receives grant to support graduate students in the family nurse practitioner program 56850 1UM receives grant to support graduate students in the family nurse practitioner program 56850 2Second hand smoking results in liver disease study finds 9877 1Second hand smoking results in liver disease study finds 9877 2Ritter Pharmaceuticals Hires Dr Howard Foyt as Executive Vice President Development 26 Chief Medical Officer 56849 1Ritter Pharmaceuticals Hires Dr Howard Foyt as Executive Vice President Development 26 Chief Medical Officer 56849 2
...sts have put more meat on the theory that dinosaur..., Molecular analysis, or genetic sequencing, of a...m the dinosaur,s femur confirms that T. rex shares...o a lesser extent, alligators. , The dinosaur pro...ered in 2003 by paleontologist John Horner of the ...
...s are increasingly being marketed a broad range of...ersonal genome mappingGene tests to predict future...echnology improvements, more genetic tests are ava...ilability has come the expansion of direct-to-cons...ed decisions about genetic tests" To help address ...
..., Ohio Two genes that help insulin regulate mosqu...ors to how the insects enter a dormant state to su...ens the understanding of the mosquito life cycle a... and invertebrate species weather the winter month...pecies of mosquitoes into diapause, a hibernation-...
Other Biology News:Genetic sequencing of protein from T. rex bone confirms dinosaurs' link to birds 2American College of Medical Genetics makes genetic testing recommendations in new policy statement 2Pathway found that lets mosquitoes fatten up, slow down for winter 2Pathway found that lets mosquitoes fatten up, slow down for winter 3
...ys designed for proteomic scale kinase profiling, ...ies, and drug discovery research built on the flex...thesis platform. These microarrays are available a...te - Peptide Microarray Service. Custom Probe Co...
...lotting is a commonly used technique for studying ...ein samples are electrophoresed on SDS-PAGE and tr...nylon, where they are probed with specific antibod... allow reuse of Southern and Northern blots, it ha...
...ys designed for immunological studies, vaccine dev...lexible and powerful Paraflo microfluidic on-chip ...e as part of our comprehensive Epitope Peptide Mic...tent is completely customer specified. Screen your...
...icroarrays containing peptidomimetics built on the...p synthesis platform. These microarrays are availa...croarray Service. Custom Probe Content Probe co...of customer specified peptide sequences can be syn...
Biology Products: