Navigation Links
Advantagene Announces SPA Agreement With FDA to Launch Phase 3 Trial for Novel Vaccine Aimed at Preventing Prostate Cancer Recurrence
Date:5/19/2011

AUBURNDALE, Mass., May 19, 2011 /PRNewswire/ -- Advantagene, Inc., a Massachusetts-based biopharmaceutical company, announced today that it reached an agreement with the U.S. Food and Drug Administration on a Special Protocol Assessment (SPA) for a pivotal Phase 3 clinical trial of ProstAtak™, its lead agent for patients with newly diagnosed prostate cancer. The trial is expected to accrue 711 patients starting mid-2011 with definitive results expected by 2015. The randomized study will evaluate ProstAtak's ability to prevent prostate cancer recurrence. If successful, it could yield the first drug product for newly diagnosed, localized prostate cancer.

Prostate cancer is the second most common cause of death in American men. The American Cancer Society estimates there were approximately 220,000 new prostate cancer diagnoses in 2010. And, although most patients will live at least 5 years after diagnosis, each year over 60,000 men develop recurrence of the cancer and 32,000 die of their disease.

"The SPA and initiation of this pivotal study are aimed at addressing a critical unmet medical need," said Dr. Estuardo Aguilar-Cordova, Founder and CEO of Advantagene. "If successful, ProstAtak would be the first-ever product to vaccinate against the recurrence of a cancer, in this case prostate cancer."

Since no curative therapy currently exists for recurrent prostate cancer, only palliative treatments that compromise quality of life, such as surgical or medical castration, are employed. Once these approaches fail, options include the recently approved immunotherapy Provenge® (Dendreon) or the chemotherapies Zytiga® (Johnson & Johnson) and Jevtana® (Sanofi), which provide modest survival improvements. Advantagene researchers have taken another approach entirely, i.e. preventing prostate cancer death by preventing recurrence. ProstAtak™ is designed as an "off-the-shelf" drug to kill tumor cells and stimulate a vaccine e
'/>"/>

SOURCE Advantagene, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2

Related biology technology :

1. Vermillion Announces the Appointment of Bruce Huebner to its Board of Directors
2. Ontario Institute for Cancer Research Announces Spin Off Companies Developing Promising Anticancer Technologies
3. ShangPharma Announces First Quarter 2011 Results
4. BioSpecifics Technologies Corp. Announces Data Presentations at Upcoming XVI Annual Federation of the European Societies for Surgery of the Hand Meeting
5. Watson Pharmaceuticals Announces New Research Showing RAPAFLO(R) (silodosin) Improves Outcomes for Chronic Prostatitis/Chronic Pelvic Pain Syndrome
6. Pfenex Inc., Through Its Reagent Proteins Business Division, Announces Submission of Biologics Master File for Recombinant CRM197 to US FDA
7. ACT Announces Oregon Health & Science University as Clinical Trial Site for its Phase 1/2 Clinical Trial Using hESC-Derived RPE Cells for Macular Degeneration
8. InterMune Announces Presentation of Positive Pirfenidone Data at the International Conference of the American Thoracic Society (ATS)
9. Spherix Announces First Quarter Financial Results
10. Stem Cell Assurance Announces the Filing of Its Form 10 Registration Statement
11. 3SBio Inc. Announces Unaudited First Quarter 2011 Results
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/16/2014)... 2014 According to Jeff Howell, Partner ... ITRA Global, new development in Downtown Toronto is expanding ... approving another 755 storeys of new development last week ... will be dominating the Toronto skyline for the foreseeable ... unquenchable thirst for new development. , As the Toronto ...
(Date:9/16/2014)... September 16, 2014 RENU 28, the world's ... became available for purchase in Australia and New Zealand ... tour beginning September 16th. The tour will make stops in ... Bundaberg on the 18th, Sydney on the 20th, and Melbourne ... Australia and New Zealand and to educate people about the ...
(Date:9/15/2014)... UPTON, NYHeat drives classical phase transitionsthink solid, ... happen when the temperature drops. If phase ... where quantum mechanics reigns, subtle fluctuations can ... from the U.S. Department of Energy,s Brookhaven ... explored this frigid landscape of absolute zero ...
(Date:9/15/2014)... 2014   Global Science & Technology, Inc. ... and services for satellite and weather systems, was ... Services (OASIS) from the General Services Administration (GSA) ... provide the government best-value solutions for complex professional ... in Pool 4. The OASIS SB award has ...
Breaking Biology Technology:ITRA Global Reports Downtown Toronto Real Estate Development is in High Gear 2ITRA Global Reports Downtown Toronto Real Estate Development is in High Gear 3Global Wellness Company Hosts ASEA Australia Tour September 16-22 2Elusive quantum transformations found near absolute zero 2Elusive quantum transformations found near absolute zero 3Global Science & Technology, Inc. Awarded GSA OASIS Small Business Contract 2Global Science & Technology, Inc. Awarded GSA OASIS Small Business Contract 3
... - One week before Badger football begins its 2005 ... found a new way to demonstrate their school spirit. The ... with high-powered microscopes. , ,Last month a team of UW-Madison ... an image of the university's mascot made of nanofiber hairs ...
... -- It has been a while since I have had a ... failings in this field is my 13-year-old musician son. As I am ... in my old age, off he went this summer to a week ... of playing rock all day and most of the night? This kind ...
... of Eau Claire, also operating as Online-Kiosks.net, ... channel program that enables resellers and systems integrators ... and subscription services to customers without major investments ... to offer hosted digital signage solutions to their ...
Cached Biology Technology:Nanotechnology minimizes UW's beloved mascot 2Historic lists - The greatest rock bands, rock guitarists of all time 2Historic lists - The greatest rock bands, rock guitarists of all time 3Historic lists - The greatest rock bands, rock guitarists of all time 4
(Date:9/15/2014)... processes from digestion to disease resistance. Despite the fact ... on the planet, more is known about belly-button bacteria ... and colleagues working on Panama,s Barro Colorado Island discovered ... home to more than 400 different kinds of bacteria. ... than 7,000 different kinds. , Bacteria in tropical forests ...
(Date:9/15/2014)... CAMBRIDGE, Mass. (September 15, 2014) The so-called ... which makes proteinhas long provided a simplified explanation ... in living organisms. , In reality, of ... the schema first articulated nearly 60 years ago ... DNA,s double-helix structure. For one, there are multiple ...
(Date:9/15/2014)... tapir populations may continue to drop in French Guiana, ... Office National de la Chasse et de la Faune ... reviewed data retrieved from camera traps in the Nouragues ... this data to current harvest rates in the region., ... French Guiana," said Matthias Tobler, a scientist with the ...
Breaking Biology News(10 mins):Smithsonian scientists discover tropical tree microbiome in Panama 2Scientists discover RNA modifications in some unexpected places 2
... R.I., July 28 ForensicSoft, a growing provider ... to announce the formal approval and selection of ... England. ForensicSoft,s products, which increase the speed and ... popularity among digital forensic and security professionals worldwide. ...
... the Caribbean Sea as the Isthmus of Panama arose, ... the Smithsonian Tropical Research Institute and Scripps Institution of ... species could shift from clonal to sexual reproduction it ... years later. Closure of the Isthmus of Panama involved ...
... NC For avid fishermen and anglers, the largemouth ... for minnows. A new study finds that once they ... fish-feeders have remained relatively unchanged compared with their insect- ... in aquatic ecosystems, natural selection put the breaks on ...
Cached Biology News:Nottinghamshire Police First Law Enforcement Agency to Deploy ForensicSoft in United Kingdom 2Nottinghamshire Police First Law Enforcement Agency to Deploy ForensicSoft in United Kingdom 3Sex in the Caribbean: Environmental change drives evolutionary change -- eventually 2Freshwater fish at the top of the food chain evolve more slowly 2Freshwater fish at the top of the food chain evolve more slowly 3
ANTI ALPHA FSH:B...
Collected from normal, healthy animals in carefully maintained standing herds of US orgin. Pricing: $45/unit for 1 - 10 units...
Normal donkey serum collected from healthy normal donkeys....
acridine orange 10-nonyl bromide (nonyl acridine orange)...
Biology Products: