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Advanced Life Sciences Announces Fourth Quarter and Full Year 2007 Financial Results
Date:2/19/2008

all in the range of $16 million and $17 million. The cash use will be applied toward cethromycin NDA submission activities, manufacturing costs, medical communication investments and general operating expenses. We believe that this cash balance will be sufficient to allow us to progress into a commercial partnership which will support the ongoing funding needs of the Company.

NASDAQ Marketplace Rule 4350(b)(1)(B)

The Company's independent registered public accounting firm included an explanatory paragraph in its report on the Company's 2007 financial statements related to uncertainty in the Company's ability to continue as a going concern. The Company does not have sufficient cash on-hand or other funding available as of the date of the audit opinion to meet its obligations if it submits the NDA for cethromycin thereby triggering a $10 million milestone payment. Although the Company recently completed a private placement providing it with net proceeds of $18 million and intends to secure a commercial partnership in 2008 that would provide additional capital to fund the milestone payment, there can be no assurance that it will be able to secure a commercial partnership or obtain adequate capital funding in the future to continue operations and implement its strategy, which would have an adverse effect on the Company's business and operations.

Conference Call Details

Advanced Life Sciences will host a conference call and live webcast at 10:00 a.m. Eastern Time on Tuesday, February 19, 2008 to discuss the Company's financial results for the fourth quarter and full year ended December 31, 2007.

The conference call will be webcast simultaneously over the Internet. Please visit the Investor Relations section of Advanced Life Sciences' corporate website http://www.advancedlifesciences.com. Alternatively, callers may participate in the conference call by dialing 888-713-4215 (
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SOURCE Advanced Life Sciences Holdings, Inc.
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