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AdvanDx's PNA FISH(TM) Test Shown to Reduce Mortality by 42% for Patients With Hospital-Acquired Enterococcus faecium Bloodstream Infections
Date:10/22/2008

nfections and the earlier initiation of effective antimicrobial therapy for patients with hospital-acquired E. faecium bloodstream infections," said Dr. Graeme Forrest, Division of Infectious Diseases, University of Maryland Medical Center and lead author of the study.

"We are very excited to see the results from the University of Maryland Medical Center study. Not only do they show that PNA FISH significantly speeds up species identification results from the lab, but also that using the results to tailor therapy at an earlier stage in bloodstream infections can significantly improve patient care and outcomes," said Thais T. Johansen, President and CEO of AdvanDx. "If we extrapolate the data to the rest of the country, PNA FISH could help ensure that all of the 18,000 patients with hospital-acquired enterococcal bloodstream infections receive effective antibiotic therapy as early as possible and help save close to 2,000 lives. In essence, implementing PNA FISH and providing rapid results to clinicians could be more beneficial than any new antibiotic to treat the infections," Johansen added.

About Bloodstream Infections

Every year, 350,000 patients contract bloodstream infections, causing over 90,000 unnecessary deaths and significant costs to the healthcare system. The infection is detected when a culture of the patient's blood (i.e. a blood culture) turns positive with bacteria and yeast. Rapid and accurate identification of the specific infecting pathogen is crucial to ensure early and appropriate therapy and save patient lives.

About PNA FISH(TM)

PNA FISH is an easy-to-use and highly sensitive and specific fluorescence in situ hybridization (FISH) assay that uses PNA (peptide nucleic acid) probes to target species specific ribosomal RNA (rRNA) in live bacteria and yeast. The unique properties of the non-charged, peptide backbone of PNA probes enable the use of FISH assays in exceedingly complex sample matrixes, such as blood and
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