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AdvanDx's PNA FISH(TM) Test Shown to Reduce Mortality by 42% for Patients With Hospital-Acquired Enterococcus faecium Bloodstream Infections
Date:10/22/2008

rococci, including E. faecium, directly from GPCPC positive blood cultures in hours instead of days. As a result, laboratories can provide faster information that enables clinicians to select effective antibiotic therapy sooner for patients afflicted with enterococcal bloodstream infections.(1)

The study included 224 patients with hospital-acquired enterococcal bloodstream infections; 112 patients before the PNA FISH test was implemented (Pre-PNA FISH group) and 112 after implementation (PNA FISH group). A treatment algorithm based on the rapid PNA FISH results was developed and implemented by the hospital's antimicrobial management team. Patients with E. faecalis by PNA FISH were to be given ampicillin, while patients with other enterococci, including E. faecium, and at "high risk" for VRE were to be given linezoid, a newer anti-VRE antibiotic. At the end of the study, data on characteristics, therapy and outcomes between the Pre-PNA FISH and PNA FISH patients groups were compared.(1)

Significant UMMC Study Data (Pre-PNA FISH vs. PNA FISH Groups)(1)

-- More than 88% of all E. faecium were resistant to vancomycin (VRE) and

100% were resistant to ampicillin

-- 84% of initial empirical antimicrobial therapy for patients with E.

faecium BSI's was inadequate

-- 2.6 days reduction in time to laboratory identification results in PNA

FISH group

-- 1.8 days reduction in time to appropriate antimicrobial therapy for E.

faecium in PNA FISH group

-- 42% reduction in 30-day mortality rates for patients with E. faecium in

PNA FISH group

-- PNA FISH Sensitivity, Specificity, Positive Predictive Value and

Negative Predictive Value shown to be 100% compared to conventional

methods

"Use of PNA FISH in conjunction with a treatment algorithm led to earlier identification of the Enterococcus species for patients with hospital-acquired enterococcal bloodstream i
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SOURCE AdvanDx
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