The study included 224 patients with hospital-acquired enterococcal
bloodstream infections; 112 patients before the PNA FISH test was
implemented (Pre-PNA FISH group) and 112 after implementation (PNA FISH
group). A treatment algorithm based on the rapid PNA FISH results was
developed and implemented by the hospital's antimicrobial management team.
Patients with E. faecalis by PNA FISH were to be given ampicillin, while
patients with other enterococci, including E. faecium, and at "high risk"
for VRE were to be given linezoid, a newer anti-VRE antibiotic. At the end
of the study, data on characteristics, therapy and outcomes between the
Pre-PNA FISH and PNA FISH patients groups were compared.(1)
Significant UMMC Study Data (Pre-PNA FISH vs. PNA FISH Groups)(1)
-- More than 88% of all E. faecium were resistant to vancomycin (VRE) and
100% were resistant to ampicillin
-- 84% of initial empirical antimicrobial therapy for patients with E.
faecium BSI's was inadequate
-- 2.6 days reduction in time to laboratory identification results in PNA
-- 1.8 days reduction in time to appropriate antimicrobial therapy for E.
faecium in PNA FISH group
-- 42% reduction in 30-day mortality rates for patients with E. faecium in
PNA FISH group
-- PNA FISH Sensitivity, Specificity, Positive Predictive Value and
Negative Predictive Value shown to be 100% compared to conventional
"Use of PNA FISH in conjunction with a treatment algorithm led to
earlier identification of the Enterococcus species for patients with
hospital-acquired enterococcal bloodstream i
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