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Adheron Therapeutics Names New Senior Leadership
Date:9/11/2013

antibody that inhibits Cad-11. The company, which Dr. Brenner and Dr. David Lee established in 2006 as Synovex Corporation, plans to evaluate the benefits of this antibody in multiple therapeutic areas including cancer, rheumatoid arthritis and fibrosis, and advance it through clinical proof of concept. Adheron has just completed a Phase I single ascending-dose study for its lead asset, the Cad-11 inhibitor SDP051. 

Adheron Therapeutics is funded by Health Care Ventures, MedImmune Ventures, Partners Innovation Fund, Amgen Ventures, and SROne.

About CAD 11
Cadherin-11 (Cad-11) is a surface protein expressed on fibroblasts in the skin and lungs, and fibroblast-like synoviocytes (FLS) in the joints. Cad-11 acts as an "adhesive" between cells, and changes in Cad-11 interactions can induce the cells to produce proteins that influence the cellular environment positively or adversely. Research completed in the laboratory of Michael Brenner, MD, at Brigham and Women's Hospital and Harvard Medical School has implicated Cad-11 in the disease processes leading to rheumatoid arthritis. Work initiated in Dr. Brenner's laboratory by Dr. Sandeep Agarwal, now at Baylor College of Medicine, has also demonstrated that Cad-11 plays a role in diverse fibrotic diseases.

About Adheron Therapeutics
Adheron Therapeutics is a biotechnology company focused on leveraging pioneering technology that disrupts cell adhesion to treat a variety of diseases. Founded by Dr. Brenner and Dr. Lee of Harvard Medical School, the company is led by industry veterans Bob Baltera (executive chairman) and Hari Kumar, PhD (CEO), and funded by a group of venture investors comprising Health Care Ventures, MedImmune Ventures, Partners Investment Fund, Amgen Ventures, and SROne.

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