Navigation Links
Addrenex Pharmaceuticals Licenses New Compound to Sciele Pharma for the Treatment of Hypertension and Other Potential Indications
Date:7/1/2008

DURHAM, N.C., July 1 /PRNewswire/ -- Two years after Addrenex Pharmaceuticals set it sights on building a new class of drugs to regulate "adrenergic excess," the small Durham company has signed its second major deal with Sciele Pharma, this time to co-develop a new compound for hypertension and other potential indications.

Adrenalin is well known as the hormone that triggers the "fight or flight" reaction in response stress or danger. But Addrenex scientists recognized this hormone, and its counterpart in the brain, noradrenalin, as regulators of diverse physiologic functions -- from blood pressure to energy expenditure to thermostatic control.

"No other company is targeting adrenergic regulation as the root cause of conditions," said Moise Khayrallah, CEO of Addrenex. "We built our company to address a wide range of conditions whose symptoms are being partially managed by drugs currently on the market, but whose origins have never been specifically treated."

Last year the company efficiently advanced its first products, Clonicel(R) to treat attention deficit hyperactivity disorder and CloniBID to treat hypertension, into Phase 3 clinical trials. In July 2007, Addrenex licensed both products to Sciele Pharma for $6 million in upfront equity, $11 million in milestones, and future royalty payments on product sales.

One year later, the company has signed this second, larger deal, to include up to $27 million in development and regulatory milestones and future royalty payments on product sales. In addition, Sciele will pay all development costs.

"The partnership with Sciele is particularly rewarding because validates our work to date and confirms that our products may fill a critical gap in the treatment of debilitating conditions," said Khayrallah.

Addrenex began its foray into drug development by tweaking an existing drug, clonidine, to extend its benefits and reduce bothersome side effects. Company co-founder Joseph Ho
'/>"/>

SOURCE Addrenex Pharmaceuticals
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2

Related biology technology :

1. Addrenex Pharmaceuticals Reaches Milestone with Filing of NDA for First Product, CloniBID, to Treat Hypertension
2. Peregrine Pharmaceuticals Awarded DTRA Contract Worth up to $44.4 Million to Develop Bavituximab for Viral Hemorrhagic Fevers
3. Webcast Alert: Isis Pharmaceuticals Announces a Business Update Conference Call
4. Alseres Pharmaceuticals, Inc. Raises $5 Million
5. Raptor Pharmaceuticals Closes $10 Million Private Placement
6. SGX Pharmaceuticals Submits Investigational New Drug Application for SGX393
7. VIA Pharmaceuticals Set to Join Russell Microcap Index
8. Wyeth Pharmaceuticals Announces Organizational Change
9. Access Pharmaceuticals Presents New Data at International Symposium Showing Companys Angiolix(R) Monoclonal Antibody has Potential to Treat Cancer by Attacking Cancer Stem Cells
10. Keryx Biopharmaceuticals to Present at the Jefferies & Co. Healthcare Conference
11. Portola Pharmaceuticals Names William Lis Vice President of Business Development and Commercial Operations
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... September 30, 2014 Rainbow Scientific, ... research products, recently opened an online store to ... culture product lines developed and manufactured by Biological ... store include Biological Industries’ Nutristem® serum-free, xeno-free reagents ... embryonic stem cell (hESC) culture. , The ...
(Date:9/30/2014)... Whitehouse Laboratories is pleased to ... Parenteral Drug Association (PDA) to host a unique ... closure integrity testing. This lecture/laboratory course will examine the ... detailed in the recently proposed revision to USP 1207 ... will span container closure integrity testing (leak testing) critical ...
(Date:9/29/2014)... 30, 2014 Each year in ... require medical attention. In the military, burn injury ... to battlefield medical care. More than 800 service ... Burn wounds heal slowly, remain inflamed and often ... physically debilitating and functionally damaging. While developments in ...
(Date:9/29/2014)... BEACH, Va. , Sept. 29, 2014 /PRNewswire-USNewswire/ ... from the fields of cartilage repair, regeneration, allograft ... attendees from around the world gathered to discuss ... LifeNet Health Institute of Regenerative Medicine symposium, ... Direction . Topics included Orthopedic Biosurgery, Minced Juvenile ...
Breaking Biology Technology:Rainbow Scientific, Inc. opens online store for state-of-the-art stem cell culture and cytogenetic reagents 2Whitehouse Laboratories to Partner with PDA for Educational Course on Container Closure Integrity Testing 2Whitehouse Laboratories to Partner with PDA for Educational Course on Container Closure Integrity Testing 3Whitehouse Laboratories to Partner with PDA for Educational Course on Container Closure Integrity Testing 4Faster Healing with Fewer Scars 2World Renowned Experts Discuss Future Of Cartilage Regeneration 2World Renowned Experts Discuss Future Of Cartilage Regeneration 3
... by hiring laboratory reagent and diagnostics industry veteran , ... ... Inc., a high-tech provider of rapid prototyping and manufacturing services ... President of Operations. Dr. Anderson brings years of entrepreneurial and ...
... for November 6, 2008 at 10:00 a.m. EST, EAST ... ) today reported financial results for,the three and nine months ... of 2008 was $18.2 million or $0.34 per basic and ... net loss of $14.6,million or $0.28 per basic and diluted ...
... announced today the,submission of the response to the ... in Single Dose Containers). In an,Approvable Letter received ... with respect to chemistry, manufacturing, and controls (CMC)., ... complete response as a Class 2,resubmission, under which ...
Cached Biology Technology:ALine, Inc. Expands Management, Adding Roger Anderson, Ph.D., as VP of Operations 2Savient Pharmaceuticals Reports Third Quarter 2008 Financial Results 2Savient Pharmaceuticals Reports Third Quarter 2008 Financial Results 3Savient Pharmaceuticals Reports Third Quarter 2008 Financial Results 4Savient Pharmaceuticals Reports Third Quarter 2008 Financial Results 5Savient Pharmaceuticals Reports Third Quarter 2008 Financial Results 6Savient Pharmaceuticals Reports Third Quarter 2008 Financial Results 7Savient Pharmaceuticals Reports Third Quarter 2008 Financial Results 8Savient Pharmaceuticals Reports Third Quarter 2008 Financial Results 9Savient Pharmaceuticals Reports Third Quarter 2008 Financial Results 10SALVAT Announces Submission of Complete Response to FDA Approvable Letter for CETRAXAL(R) 2
(Date:9/29/2014)... 2014 Growing Demand From ... Increasing Security Concerns Continue to Propel Biometrics Market ... is one of the fastest growing biometrics ... systems, majorly in various government projects such as ... based biometrics dominates the country,s biometrics market, with ...
(Date:9/29/2014)... release is available in French . ... - The number of days an expectant mother was ... the epigenetic profile of her child, a new study ... and McGill University have detected a distinctive ,signature, in ... the massive Quebec ice storm. Five months after the ...
(Date:9/28/2014)... at the University of California, Santa Cruz, suggest that ... genomes of primates drove the evolution of complex regulatory ... cell of our bodies. , The arms race ... "jumping genes") and the genes that have evolved to ... the first time, identified genes in humans that make ...
Breaking Biology News(10 mins):India Biometrics Market to Surpass USD2.7 Billion by 2019, Finds TechSci Research Study 2India Biometrics Market to Surpass USD2.7 Billion by 2019, Finds TechSci Research Study 3Human genome was shaped by an evolutionary arms race with itself 2Human genome was shaped by an evolutionary arms race with itself 3Human genome was shaped by an evolutionary arms race with itself 4
... to combat osteoporosis and other human common diseases is ... project "BlueGenics" which has received funding of EUR 6 ... team, coordinated by Professor Dr. Werner E.G. Mller from ... Medical Center, intends to identify and to utilize genetic ...
... believe that this knowledge may be important for the ... health issues, that modern science still hasn,t been able ... Center for Infectious Medicine at Karolinska Institutet and the ... time, it,s important to emphasize that humans have lived ...
... 2012 More than 100 academic institutions and ... initiative: Mathematics of Planet Earth (MPE) 2013. This ... mathematics in tackling global problems, including natural disasters ... sustainability; and pandemics. MPE2013 partners will sponsor workshops, ...
Cached Biology News:Launch of the EU large-scale integrating project 'BlueGenics' to combat osteoporosis 2Launch of the EU large-scale integrating project 'BlueGenics' to combat osteoporosis 3How the common 'cat parasite' gets into the brain 2Mathematicians tackle global issues 2Mathematicians tackle global issues 3
... stain kits are optimized for use ... Dodeca stainers. This silver stain kit ... in polyacrylamide gels and are mass ... concentrate, silver reagent concentrate, background reducer ...
... This PTC-100 thermal cycler holds 96 x ... Hot Bonnet heated lid incorporates a thumbwheel ... seal PCR vessels for oil-free cycling. Peltier ... NIST-traceable calibration and ramping rates of up ...
BioGenex IHC Kits for Rodent Tissues are designed for immunohistochemistry on rodent and rabbit tissues that are closely related to the source of the primary antibody. This kit comes with rat seconda...
EZ-DeWax is a one-step solution that simultanously removes paraffin from and rehydrates formalin-fixed, paraffin embedded tissue...
Biology Products: