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Adaptive Biotechnologies Receives $2.53 million Phase II SBIR to Develop Test to Identify Cancer Patients at Risk of Death by Infection after Cord Blood Transplants
Date:9/13/2013

eration Sequencing platform, immunoSEQ™, will be used in the phase II study to measure T-cell and B-cell diversity. The study will be conducted prospectively over a three-year period on approximately 400 cord blood transplant recipients from five of the top transplant centers in the United States. Patients' blood will be drawn at several time points after transplant and shipped to Adaptive's CLIA-certified centralized laboratory in Seattle. The company's immunosequencing platform and accompanying bioinformatics tools will be used to calculate a precise measure of diversity for each patient at each time point. While cord blood transplant serves as an ideal model to confirm the importance of immune reconstitution because of the higher incidence of infectious morbidity and mortality compared to other tissue sources used for stem cell transplants, the results should apply to all stem cell transplantation procedures.

This test of immunocompetence will add to Adaptive's portfolio of products that use immunosequencing for prognosis, diagnosis, and monitoring of cancer patients. The company's first clinical application, clonoSEQ™, is for monitoring Minimal Residual Disease ("MRD") in blood-based cancers.

About Adaptive Biotechnologies

Adaptive Biotechnologies Corporation ("Adaptive" or the "Company") is a development stage biotechnology company that utilizes its proprietary immune profiling technology to discover, develop, and commercialize oncology diagnostics. The Company leverages advances in next generation sequencing ("NGS") to profile T-Cell and B-Cell Receptors ("TCRs" and "BCRs").  This breakthrough enables in-depth characterization of the immune system, which is the primary defense against cancer. By incorporating immunosequencing into clinical care, Adaptive can enhance the diagnosis, prognosis, and monitoring of cancer patients. The Company's first clinical
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