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Adaptive Biotechnologies Publishes 'Gold Standard' Method for Sequencing Cells of the Adaptive Immune System
Date:10/25/2013

and after amplification can be precisely measured.  The amplification process can then be adjusted and corrected so that it is accurate and truthfully represents the level of each receptor present in a given tissue or patient sample. 

"Now, with the proven ability to control for bias, the quantitative accuracy essential for clinical decision making is truly possible" explained Dr. Harlan Robins, corresponding author, Adaptive Biotechnologies co-founder and associate faculty member at the Fred Hutchinson Center. As demonstrated in the publication, this SISTM bias control system ensures state-of-the art accuracy of Adaptive's assay in measuring the frequency of biological TCR and BCR rearrangements present in a complex background, including the detection of minimal residual disease (MRD) in patients who suffer from leukemia or lymphoma.

"Adaptive's bias control method has significant business implications in that these templates will be used as a set of in-line controls for all Adaptive research and clinical assays going forward. Of particular importance, this advance enables Adaptive to develop a kit for outside laboratories to perform this bias-controlled assay at their own sites. These bias control templates will ensure cross-lab standardization," noted CEO and co-founder, Chad Robins. This product will be marketed first as a Research Use Only product, but the Company intends to seek 510K clearance for in vitro diagnostic products, initially focused in oncology.

About Adaptive Biotechnologies

Adaptive Biotechnologies Corporation ("Adaptive" or the "Company") is a pioneer in immunosequencing diagnostics, with a focus in oncology. The Company leverages advances in next generation sequencing ("NGS") to profile T-Cell and B-Cell Receptors ("TCRs" and "BCRs").  This breakthrough enables in-depth characterization of the immune system, which is the prim
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