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Adaptive Biotechnologies Publishes 'Gold Standard' Method for Sequencing Cells of the Adaptive Immune System
Date:10/25/2013

SEATTLE, Oct. 25, 2013 /PRNewswire/ -- Adaptive Biotechnologies Corporation, a leading provider of next-generation oncology diagnostics, announced today the publication of a method to significantly improve the accuracy of next-generation immune system profiling by creating a fully validated Synthetic Immune System (SISTM) to control for any possible bias caused by the amplification method  used to characterize the enormous complexity of the adaptive immune system.  The SIS method, developed and validated in Adaptive's Seattle laboratories is described in the October 25th issue of Nature Communications, and demonstrates the Company's fundamental commitment to data quality.

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The complexity of the adaptive immune system, marked by millions of distinctly individual cells  (called "T-" and "B-"cells) each one of which carries on its surface a unique and distinguishing set of receptors is actually what enables an individual to defend against the vast array of potential pathogens h/she might encounter. A critical first step in profiling the adaptive immune system is the generation of millions of replicas of the individual cell-specific blueprints ("amplification" of the receptor-specific DNA) for these different receptors and then definition of each one of them by high-throughput DNA sequencing. Because of the inherent and important diversity of these receptors, achieving equivalent amplification (critically important to accurately measure the immune response) is problematic.

To correct for this possible amplification bias, Adaptive has created a set of synthetic templates that mimic biological T cell receptor rearrangements.  Using molecular design, the relative concentration of each of these templates both before
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SOURCE Adaptive Biotechnologies Corporation
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