Navigation Links
Acologix Presents Preclinical Data on Cartilage Regeneration by AC-100 at the 30th ASBMR Annual Meeting
Date:9/12/2008

HAYWARD, Calif., Sept. 12 /PRNewswire/ -- Acologix, Inc., a privately held biopharmaceutical company, today announced the results of two preclinical studies demonstrating that AC-100, its therapeutic product candidate derived from an endogenous human protein produced by bone and dental cells, promotes cartilage regeneration in large animal models. The data will be presented by Dr. Catherine A. Middleton-Hardie on September 13, 2008 at the 30th ASBMR (American Society for Bone and Mineral Research) Annual Meeting in Montreal, Canada.

The effects of AC-100 on cartilage regeneration were evaluated in goats with standardized medial femoral condylar (knee cartilage) defects. In one study, deep defects in knee cartilage and underlying bone were treated with a collagen sponge containing AC-100 or placebo followed by three weekly intra-articular injections of the test articles into the operated knee joint. Cartilage regeneration was evaluated after three and six months. In another study, a more superficial knee cartilage defect that did not reach the bone was treated with four weekly intra-articular injections of AC-100 or placebo. In half of the goats in each group, microfracture surgery, used clinically to promote healing, was performed. Cartilage was evaluated after 6 weeks to investigate early regeneration.

In both studies, AC-100 dose dependently promoted cartilage repair compared to placebo. AC-100 treatment increased cartilage regeneration both with and without microfracture. AC-100 demonstrated a favorable safety profile in the study, with no inflammatory response.

These results suggest that repair of both severe and non-severe knee cartilage defects may be improved with intra-articular AC-100, with or without concomitant microfracture procedures.

"Results thus far for cartilage regeneration in experimental injury models, as well as the excellent safety profile of AC-100, provide strong support for initiating clinical development of AC-100 in osteoarthritis and traumatic cartilage injury," said Dr. Dawn McGuire, Chief Medical Officer of Acologix. "AC-100 is unique as a medical treatment potentially promoting regeneration of injured cartilage and underlying bone, as well as providing meaningful symptomatic relief."

Acologix, Inc.

Acologix, Inc. a privately held biopharmaceutical company, is developing and commercializing novel biopharmaceuticals targeting osteo-renal indications, including the complications with chronic kidney disease and dialysis, bone and cartilage repair and regeneration, and general dental and oral care. The company's most advanced program, AC-820 (TRK-820) is in Phase 3 and registration stages in the U.S. and Japan, respectively for the treatment of uremic pruritus in dialysis patients. The second program, AC-100, a new class of hard tissue growth promoting molecule, has been studied in two Phase II clinical studies and demonstrated high safety profile and selective hard tissue formation activities in dental restoration procedures. Further studies have revealed more evidences that AC-100 selectively promotes bone and cartilage repair and regeneration. Acologix is also developing AC-200 (Phosphatonin) to treat hyperphosphatemia and renal osteodystrophy. For more information, go to http://www.acologix.com.

Abstract Number 193 "AC-100 Promotes Cartilage Repair and Sub-Chondral Bone Healing in Surgically Induced Cartilage Defects." by Catherine Middleton-Hardie, Ph.D., David Rosen, Ph.D., Birthe Schnegelsberg, Ph.D., Robert Spiro, Ph.D. of Acologix, Harold Aberman, D.V.M., Tim Simon, Ph.D. of Applied Biological Concepts. Presented as Poster #SA111 by Dr. Middleton-Hardie on Saturday, September 13, 2008, at the 30th ASBMR Annual Meeting in Montreal, Canada.

This press release contains "forward-looking" statements. These statements involve risks and uncertainties, which may cause results to differ materially from those set forth in the statements. The forward-looking statements include statements regarding product development and cannot be guaranteed. Acologix undertakes no obligation to publicly update any forward-looking statement, whether as a result of new information, future events, or otherwise. Forward-looking statements in this press release should be evaluated together with the many uncertainties that affect Acologix' business.


'/>"/>
SOURCE Acologix, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Related biology technology :

1. Bluestar Silicones Presents Adhesive Gels for Wound Care at Medical Grade Polymers Conference
2. Access Pharmaceuticals Presents New Data at International Symposium Showing Companys Angiolix(R) Monoclonal Antibody has Potential to Treat Cancer by Attacking Cancer Stem Cells
3. Ardea Biosciences Presents Inflammation Program Data for Arthritis and Gout at 2008 Annual European Congress of Rheumatology
4. Peregrine Pharmaceuticals Presents Promising Phase I Data at ASCO and Provides Clinical Update on Its Phase II Bavituximab Breast Cancer Study
5. FASgen, Inc. Presents Ovarian Cancer Efficacy and Toxicology Data to the American Association for Cancer Research
6. Anthera Presents Data on Varespladib at ATVB Meeting
7. Telik Presents Preclinical Data at 99th Annual Meeting of the American Association for Cancer Research
8. ProMetic presents preclinical data for prostate and pancreatic cancer at the AACR Meeting
9. NexGenix Pharmaceuticals Presents Data on a Novel Small Molecule Inhibitor of Heat Shock Protein 90 (Hsp90) at the Annual Meeting of the American Association for Cancer Research (AACR); Scientific Advisory Board Chairman Tyler Jacks Named President-elect
10. Kosan Presents Preclinical Data on Novel Third-Generation Hsp90 Inhibitors at AACR
11. Lorus Therapeutics presents new findings for the anticancer drugs LOR-253 and LOR-2040
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... Lemonade Stand Foundation (ALSF), a leading national childhood cancer ... bioinformatics lab, using ,big data, to advance the pace ... Liz Scott , co-executive director of ALSF and Alex,s ... Washington, D.C. , hosted by Vice President ... pediatric cancer research and awareness. The ...
(Date:6/27/2016)... 27, 2016  Global demand for enzymes is ... 2020 to $7.2 billion.  This market includes enzymes ... products, biofuel production, animal feed, and other markets) ... biocatalysts). Food and beverages will remain the largest ... consumption of products containing enzymes in developing regions.  ...
(Date:6/27/2016)... /PRNewswire/ - BIOREM Inc. (TSX-V: BRM) ("Biorem" or "the Company") ... shareholders, Clean Technology Fund I, LP and Clean Technology ... based venture capital funds which together hold approximately 59% ... diluted, as converted basis), that they have entered into ... holdings in Biorem to TUS Holdings Co. Ltd. ("TUS") ...
(Date:6/27/2016)... 2016  Sequenom, Inc. (NASDAQ: SQNM ), ... through the development of innovative products and services, announced ... United States denied its petition to review ... Sequenom,s U.S. Patent No. 6,258,540 (",540 Patent") are not ... the Supreme Court,s Mayo Collaborative Services v. Prometheus Laboratories ...
Breaking Biology Technology:
(Date:6/27/2016)... 27, 2016 Research and Markets has announced ... report to their offering. ... to grow at a CAGR of 12.28% during the ... on an in-depth market analysis with inputs from industry experts. The ... coming years. The report also includes a discussion of the key ...
(Date:6/22/2016)... Md. , June 22, 2016  The American College ... Trade Show Executive Magazine as one of the ... on May 25-27 at the Bellagio in Las ... on the highest percentage of growth in each of the ... of exhibiting companies and number of attendees. The 2015 ACMG ...
(Date:6/22/2016)... ANGELES , June 22, 2016 /PRNewswire/ ... identity management and verification solutions, has partnered ... edge software solutions for Visitor Management, Self-Service ... provides products that add functional enhancements ... partnership provides corporations and venues with an ...
Breaking Biology News(10 mins):