Navigation Links
Accumetrics Announces Publication of GRAVITAS Primary Results in JAMA

SAN DIEGO, March 15, 2011 /PRNewswire/ -- Accumetrics, Inc., developer of the VerifyNow® System, the first rapid and easy-to-use point-of-care system for measuring platelet reactivity to multiple antiplatelet agents, announced today that the primary results of the GRAVITAS trial have been published in The Journal of the American Medical Association(1).

First presented at the American Heart Association's Annual Scientific Sessions in November 2010, the results refute a "one-size fits all" strategy of uniformly doubling the dose of clopidogrel (Plavix®) over six months for patients with high on-treatment platelet reactivity (low response) after taking a standard dose of the commonly prescribed antiplatelet drug.

While there was a modest reduction in platelet reactivity in GRAVITAS patients receiving a 6-month double dose of Plavix compared to the standard dose, it was not sufficient to impact overall outcomes, leading the authors to suggest that more potent platelet inhibition may have been beneficial.

Further, and consistent with numerous previous studies, the trial demonstrated an association between high on-treatment platelet reactivity and the occurrence of adverse cardiac events such as death, heart attack and stent thrombosis.

"The GRAVITAS findings do not support a uniform treatment strategy for patients with high on-treatment platelet reactivity," said Matthew J. Price, MD, of the Scripps Translational Science Institute and Scripps Clinic in La Jolla, CA, lead author of the article and Principal Investigator of the GRAVITAS trial. "Rather than prescribing a fixed, higher dose of clopidogrel based on a single post-PCI platelet function test, we need to consider alternative treatment strategies that incorporate platelet function testing, such as using more potent antiplatelet agents or repeated testing to a specific target of reactivity."

The article reports that 41% of patients in the GRAVITAS trial had high on-treatment platelet reactivity after receiving Plavix®. This is consistent with previous studies that show that up to 1 in 3 patients may not be responding adequately to their antiplatelet therapy. Numerous factors are associated with low platelet response, including pre-existing health conditions such as diabetes, interference from other medications, non compliance and genetics.

"GRAVITAS underscores the need to develop more individualized treatment strategies for cardiovascular patients," said Timothy I. Still, President and CEO of Accumetrics. "As more antiplatelet treatment options become available, the VerifyNow System continues to help clinicians better assess a patient's response to therapy."

The VerifyNow System is widely used in various clinical settings where antiplatelet medications are prescribed to reduce the occurrence of future thrombotic events such as heart attack and stroke.

(1)  Price MJ, Berger PB, Teirstein PS, et al. Standard- vs High-Dose Clopidogrel Based on Platelet Function Testing After Percutaneous Coronary Intervention. JAMA.2011;305[11]1097-1105.

AboutAccumeicsAccumetrics is committed to advancing medical understanding of platelet function and enhancing quality of care for patients receiving antiplatelet therapies by providing industry-leading and widely accessible diagnostic tests for rapid platelet function assessment.

Accumetrics' VerifyNow System is the first rapid and easy-to-use platform to help physicians determine an individual's response to multiple antiplatelet agents. Addressing every major antiplatelet drug, including FDA-cleared products for aspirin, P2Y12 inhibitors (e.g. prasugrel (Effient®) and clopidogrel (Plavix®)), and GP IIb/IIIa inhibitors (e.g. ReoPro® and Integrilin®), the VerifyNow System provides valuable information to help physicians make informed treatment decisions. For more information about the Company and its products, visit

The Accumetrics logo and VerifyNow are registered trademarks of Accumetrics, Inc. ReoPro is a registered trademark of Centocor, Inc. Integrilin is a registered trademark of Millennium Pharmaceuticals. Plavix is a registered trademark of sanofi-aventis. Effient is a registered trademark of Eli Lilly and Company.CONTACT:Jakob Jakobsen310-309-1003Jjakobsen@ccapr.comTimothy I. Still President and CEO

SOURCE Accumetrics, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Related biology technology :

1. Timothy I. Still Appointed CEO at Accumetrics
2. Accumetrics Appoints John J. Young, MD Chief Medical Officer
3. Andrew Chisholm Appointed Vice President, Sales and Corporate Accounts at Accumetrics
4. Accumetrics, Inc. Announces European Distribution Channels for France, Austria, Switzerland, Netherlands, Belgium and Luxembourg
5. China-Biotics, Inc. Announces Conference Call to Discuss First Quarter 2009 Financial Results
6. Odyssey Thera Announces Milestone Achievement in Pfizer Alliance
7. InNexus Biotechnology Announces Launch of Large Scale Primate Study of DXL625
8. Anesiva Announces Second Quarter 2008 Financial Results and Update
9. SGX Pharmaceuticals Announces Financial Results for the Three and Six Months Ended June 30, 2008
10. Insmed Announces Financial Results for Second Quarter and Six-Months Ended June 30, 2008
11. China Sky One Medical, Inc. Announces Conference Call to Discuss Second Quarter 2008 Results
Post Your Comments:
(Date:11/25/2015)... , Nov. 25, 2015 Orexigen® Therapeutics, ... will participate in a fireside chat discussion at the ... New York . The discussion is scheduled for ... .  A replay will be available ... Contact:McDavid Stilwell  , Julie NormartVP, Corporate Communications and ...
(Date:11/24/2015)... LUMPUR, Malaysia , Nov. 24, 2015 /PRNewswire/ ... global contract research organisation (CRO) market. The trend ... result in lower margins but higher volume share ... increased capacity and scale, however, margins in the ... Research Organisation (CRO) Market ( ), ...
(Date:11/24/2015)... SAN DIEGO , Nov. 24, 2015 Halozyme Therapeutics, ... Jaffray Healthcare Conference in New York on ... Dr. Helen Torley , president and CEO, will provide a ... New York at 1:00 p.m. ET/10:00 a.m. ... communication and investor relations, will provide a corporate overview. --> ...
(Date:11/24/2015)... ... November 24, 2015 , ... International Society ... one of the premier annual events for pharmaceutical manufacturing: 2015 Annual Meeting. The ... where ISPE hosted the largest number of attendees in more than a decade. ...
Breaking Biology Technology:
(Date:11/4/2015)... , November 4, 2015 ... market report published by Transparency Market Research "Home Security Solutions ... and Forecast 2015 - 2022", the global home security solutions ... bn by 2022. The market is estimated to expand ... from 2015 to 2022. Rising security needs among customers ...
(Date:10/29/2015)... , Oct. 29, 2015 Daon, a ... that it has released a new version of its ... in North America have already ... v4.0 also includes a FIDO UAF certified server ... already preparing to activate FIDO features. These customers include ...
(Date:10/29/2015)... Oct. 29, 2015 Today, LifeBEAM ... partnership with 2XU, a global leader in technical ... smart hat with advanced bio-sensing technology. The hat ... to monitor key biometrics to improve overall training ... the two companies will bring together the most advanced ...
Breaking Biology News(10 mins):