Navigation Links
Accounting for biological aggregation in heating and imaging of magnetic nanoparticles

Biological aggregation is a critical, yet often overlooked factor in the medical application of nanoparticles. Here we systematically characterize the effects of aggregation on both radiofrequency heating and magnetic resonance image (MRI) contrast of magnetic iron oxide nanoparticles (IONPs), including detailed analysis of the aggregate morphologies based on quasi-fractal descriptions. While aggregation is shown to produce significant reductions in both heating and MRI contrast, we also present a new method to quantify and correlate these effects for clinical applications, such as cancer hyperthermia, utilizing sweep imaging with Fourier transform (SWIFT) MRI. Therefore, the results of this work not only present new methods to systematically examine a poorly understood area of nanomedicine (not unique to magnetic nanoparticles), but also demonstrate an imaging platform to account for it in the clinic.

Jack Hoopes, Ph.D., D.V.M., of Dartmouth College and Principal Investigator at the Dartmouth Center for Cancer Nanotechnology Excellence (DCCNE) says, "It is now clear that development of a clinically effective magnetic nanoparticle cancer treatment will require nanoparticles that have significant magnetic field-initiated heating potential and the ability to be observed accurately in a non-invasive, real-time manner. Your University of Minnesota MR-SWIFT imaging technology is the first to demonstrate that magnetic nanoparticles can be observed and quantified, with excellent contrast and resolution, at therapeutically meaningful levels using a conventional imaging technology. Equally important is your demonstration that SWIFT MRI can be used to predict the level of therapeutic heating for a specific amount of tumor iron (IONPs) and that IONP aggregation, in the tumor, is critical to understanding heat generation. Our DCCNE looks forward to working with you and your recently developed techniques to enhance our upcoming IONP clinical trials." The DCCNE is attempting to conduct the first in-human clinical trials related to IONP based cancer hyperthermia in the U.S.

On-going work at the University of Minnesota and Dartmouth College plans to expand on the preliminary in vivo studies presented here and demonstrate intra-operative concentration and SAR mapping for IONP treatments that will translate to the clinical setting. This includes opportunities to increase the range of measurable IONP concentrations beyond those already established (up to 3-4 mg Fe/ml) through increased acquisition bandwidth or multi-band-SWIFT. This not only has im-portant implications for cancer hyperthermia applications, but may provide a platform to perform transient, non-invasive biodistribution studies on IONPs. Finally, as the interparticle interactions due to aggregation were determined to be detrimental to the IONPs' heating potential, the authors are also investigating new ways to account for it using SWIFT (as shown here) and controlling it through new coatings which additionally increase the potential for future targeting and drug payload inclusion.


Contact: Philly Lim
World Scientific

Related biology technology :

1. Minerva Neurosciences Announces Appointment Of Frederick W. Ahlholm As VP Of Finance And Chief Accounting Officer
2. Accounting Firm Rankings: TaxOps Takes Top Small Firm Spot for the Second Consecutive Year
3. SASB Releases Provisional Sustainability Accounting Standards for Health Care Industry, A Key Milestone in Improving Disclosure of Material Non-Financial Information
4. Sequenom Announces Appointment of Carolyn Beaver to Chief Accounting Officer
5. Remcom Announces Enhanced Biological Thermal Sensor and Other Biomedical Features in XFdtd EM Simulation Software Update
6. UMD Researchers Bridge Gap between Microelectronics, Biological Systems
7. Biological Drugs Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020
8. Global Graphene Manufacturing Leader, Graphene Frontiers, Receives Series Seed B Funding To Assure Production Of The Next Generation Of Biological And Chemical Sensor Technology
9. Collaboration Between Shimadzu Corporation and the MacCoss Lab of Biological Mass Spectrometry, University of Washington
10. Virtual Finger Enables Scientists To Navigate And Analyze 3D Images Of Complex Biological Structures
11. Researcher studying biological factors of blood glucose variability wins 2013 IDF Europe Prize in Diabetes for Young Researcher
Post Your Comments:
Related Image:
Accounting for biological aggregation in heating and imaging of magnetic nanoparticles
(Date:6/23/2016)... , June 23, 2016 Apellis ... Phase 1 clinical trials of its complement C3 ... single and multiple ascending dose studies designed to ... (PD) of subcutaneous injection in healthy adult volunteers. ... (SC) either as a single dose (ranging from ...
(Date:6/23/2016)... 23, 2016 Andrew ... Published recently in ... journal from touchONCOLOGY, Andrew D Zelenetz , ... cancer care is placing an increasing burden on ... biologic therapies. With the patents on many biologics ...
(Date:6/23/2016)... San Francisco, CA (PRWEB) , ... June 23, ... ... capture (EDC) software, is exhibiting at the Pennsylvania Convention Center and will showcase ... DIA Annual conference. ClinCapture will also be presenting a scientific poster on Disrupting ...
(Date:6/23/2016)... Connecticut (PRWEB) , ... June 23, 2016 , ... ... introduce a new line of intelligent tools designed, tuned and optimized exclusively for ... September 12–17 in Chicago. The result of a collaboration among several companies with ...
Breaking Biology Technology:
(Date:5/12/2016)... -- , a brand of Troubadour Research ... the Q1 wave of its quarterly wearables survey. A ... to a program where they would receive discounts for ... "We were surprised to see that so ... , CEO of Troubadour Research, "primarily because there are ...
(Date:5/3/2016)... , May 3, 2016  Neurotechnology, a ... the MegaMatcher Automated Biometric Identification System (ABIS) ... large-scale multi-biometric projects. MegaMatcher ABIS can process multiple ... using any combination of fingerprint, face or iris ... MegaMatcher SDK and MegaMatcher Accelerator , ...
(Date:4/28/2016)... First quarter 2016:   , Revenues amounted ... quarter of 2015 The gross margin was 49% (27) ... the operating margin was 40% (-13) Earnings per share ... operations was SEK 249.9 M (21.2) , Outlook   ... M. The operating margin for 2016 is estimated to ...
Breaking Biology News(10 mins):