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Accounting for biological aggregation in heating and imaging of magnetic nanoparticles
Date:9/2/2014

Biological aggregation is a critical, yet often overlooked factor in the medical application of nanoparticles. Here we systematically characterize the effects of aggregation on both radiofrequency heating and magnetic resonance image (MRI) contrast of magnetic iron oxide nanoparticles (IONPs), including detailed analysis of the aggregate morphologies based on quasi-fractal descriptions. While aggregation is shown to produce significant reductions in both heating and MRI contrast, we also present a new method to quantify and correlate these effects for clinical applications, such as cancer hyperthermia, utilizing sweep imaging with Fourier transform (SWIFT) MRI. Therefore, the results of this work not only present new methods to systematically examine a poorly understood area of nanomedicine (not unique to magnetic nanoparticles), but also demonstrate an imaging platform to account for it in the clinic.

Jack Hoopes, Ph.D., D.V.M., of Dartmouth College and Principal Investigator at the Dartmouth Center for Cancer Nanotechnology Excellence (DCCNE) says, "It is now clear that development of a clinically effective magnetic nanoparticle cancer treatment will require nanoparticles that have significant magnetic field-initiated heating potential and the ability to be observed accurately in a non-invasive, real-time manner. Your University of Minnesota MR-SWIFT imaging technology is the first to demonstrate that magnetic nanoparticles can be observed and quantified, with excellent contrast and resolution, at therapeutically meaningful levels using a conventional imaging technology. Equally important is your demonstration that SWIFT MRI can be used to predict the level of therapeutic heating for a specific amount of tumor iron (IONPs) and that IONP aggregation, in the tumor, is critical to understanding heat generation. Our DCCNE looks forward to working with you and your recently developed techniques to enhance our upcoming IONP clinical trials." The DCCNE
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Contact: Philly Lim
mllim@wspc.com
656-466-5775
World Scientific
Source:Eurekalert  

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Accounting for biological aggregation in heating and imaging of magnetic nanoparticles
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