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Abbott's HUMIRA(R) Receives Positive Opinion From EMEA for Treatment of Moderate to Severe Plaque Psoriasis
Date:11/16/2007

response (<50 percent improvement in PASI response relative to

baseline, with a minimum six point increase in PASI score compared to

week 33) compared to patients on placebo (28 percent).

-- In CHAMPION, a pivotal 16-week study evaluating 271 psoriasis patients

from eight European countries and Canada, HUMIRA-treated patients

experienced a significant reduction in the signs and symptoms of their

disease compared with methotrexate or placebo-treated patients, with

more than twice the percentage (80 percent) of patients treated with

HUMIRA achieving a PASI 75 response compared to patients treated with

methotrexate (36 percent), a standard systemic treatment for

psoriasis, and more than four times the percentage of patients treated

with placebo (19 percent).

Nearly 17 percent of patients treated with HUMIRA achieved a PASI 100

response at week 16, compared to 7 percent of patients receiving

methotrexate and 2 percent of patients receiving placebo. In

addition, a mean percentage PASI improvement of 57 percent was

achieved at week four in patients receiving HUMIRA, compared to

baseline.

The most commonly reported adverse events in HUMIRA psoriasis trials were nasopharyngitis (inflammation of the nose and pharynx), upper respiratory tract infection and headache.

More Information About Psoriasis

Psoriasis is a chronic autoimmune disease that speeds the growth cycle of skin cells and results in thick scaly areas of skin. The most common form of psoriasis appears as red, raised areas of skin covered with flaky white scales, which may itch or burn. Psoriasis most commonly appears on the scalp, knees, elbows, lower back, hands and feet, though it can develop anywhere on the skin. It may even occur in the fingernails and toenails.

While psoriasis can occur in people of all ages, it typic
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SOURCE Abbott
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