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Abbott Scientists Present a New Approach for Treating Attention-Deficit Hyperactivity Disorder
Date:5/7/2008

ing of the therapeutic potential of NNRs for more than a decade and have published more than 75 research studies in this area.

alpha 4 beta 2 NNR Agonist Program

ABT-089 is a selective NNR agonist, which targets the alpha 4 beta 2 NNR subtype. It has demonstrated efficacy in preclinical models of attention, learning and memory deficits. It also has demonstrated efficacy in improving the core symptoms of attention-deficit hyperactivity disorder in adults. ABT- 089 is currently in Phase II clinical trials for ADHD and Alzheimer's disease.

ABT-894 is an NNR agonist, which targets the alpha 4 beta 2 NNR subtype. It has demonstrated efficacy in multiple preclinical animal models of neuropathic pain and nociceptive pain with and without an inflammatory component. ABT-894 exhibits high affinity for and full functional efficacy at the alpha 4 beta 2 NNR subtype. Similar to other NNR agonists, it also has demonstrated a cognitive enhancing profile in pre-clinical models of cognition. ABT-894 is currently in Phase II clinical trials for ADHD and diabetic neuropathic pain. This compound was discovered in collaboration with NeuroSearch.

alpha 7 NNR Agonist Program

ABT-107 is a potent and selective NNR agonist, which targets the alpha 7 NNR subtype. It has demonstrated efficacy in in vivo studies that model memory consolidation, social recognition memory, working memory, and sensory gating deficits, which are domains of cognition negatively impacted in Alzheimer's disease and schizophrenia. ABT-107 is currently in Phase I clinical trials for a variety of central nervous system disorders. This compound was discovered in collaboration with NeuroSearch.

TRPV1 Receptor Program

The TRPV1, or vanilloid receptor, plays an important role in mediating the body's response to a variety of pain stimuli, including heat and changes in pH levels, as well as a variety of mediators of inflammation that are released in the body following tissue dam
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