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Abbott Scientists Present a New Approach for Treating Attention-Deficit Hyperactivity Disorder
Date:5/7/2008

as acetylcholine and dopamine, and are an important class of ion channels (molecular "gates" that control the flow of ions in and out of cells and regulate neuron signaling) that have been associated with a number of neurological conditions.

"We have seen therapeutic promise in targeting NNRs for more than a decade, for both pain and the cognitive deficits associated with a variety of diseases, including ADHD and Alzheimer's disease," said James Sullivan, Ph.D., divisional vice president, Neuroscience Discovery, Abbott. "We are very encouraged with the results of our ADHD work; this is a condition that demands innovative treatments, particularly to address side effect issues that have been observed with current treatments."

"The studies evaluating efficacy demonstrated that ABT-089 reduced the severity of symptoms and was generally well tolerated in adults with ADHD," said Timothy Wilens, M.D., associate professor of psychiatry, director of Substance Abuse Services in Pediatric Psychopharmacology at Massachusetts General Hospital. "Not all NNR agonists may be suitable for the treatment of ADHD. By selectively targeting specific NNR receptors, ABT-089 appears to have a favorable profile for treating the condition."

Study Background and Results

Two-hundred-twenty-one adults with ADHD enrolled in the multicenter, randomized, double-blind, placebo-controlled study, which used a 2 x 2 crossover design. Each subject received both placebo (PBO) and active treatment in random sequence. Five doses of ABT-089 were evaluated: 2 mg, 5 mg, 15 mg, or 40 mg once daily (QD), or 40 mg twice daily (BID). Each treatment period was 4 weeks, separated by a 2-week washout period. The endpoint was the Investigator-rated Conners' Adult ADHD Rating Scale (CAARS- Inv) Total Score obtained at the end of each treatment period.

Results showed ABT-089 at doses of 40mg QD and 40 mg BID were generally well tolerated, did not negatively impact heart rate or blood
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