New immunohistochemistry (IHC) studies using this antibody showed that CD9 is expressed in a variety of human tumor samples, resulting in moderate to high levels of staining in 61/82 (73.5%) of tumor cells from various organs including pancreas, prostate, stomach and liver. The antibody demonstrated potent anti-tumor efficacy in in vivo models of pancreatic, breast and AML cancers and treatment led to a decrease in phosphorylation of several receptor tyrosine kinases.
CD9 is highly and differentially expressed in AML versus normal CD34+CD38- stem cells. Experiments strongly suggest that ARIUS' CD9 targeting antibody inhibits human AML outgrowth in pre-clinical studies. In secondary transplantation experiments, treatment with ARIUS' CD9 targeting antibody dramatically reduced the self-renewal capacity of AML cancer stem cells. CD9 is the first description of a marker that is differentially expressed on cancer versus normal stem cells.
Trop-2 Signal Transduction Program
AR47A6.4.2, a naked monoclonal antibody targeting Trop-2, exhibits anti-tumor efficacy in multiple human cancer models as a monotherapeutic agent and demonstrates efficacy in combination therapy. Abstract Number 3990. Experimental and Molecular Therapeutics 32, Tuesday, April 15, 2008, 8:00 AM
ARIUS shows its Trop-2 targeting antibody, AR47A6.4.2, is involved in
the MAPK pathway. This antibody demonstrated potent anti-tumor efficacy in
human pancreatic, breast, colon and prostate cancer models. In combination
with Gemcitabine, this antibody also inhibited tumor growth by 93% in a
human pancreatic cancer model. ARIUS' Trop-2 targeting antibody is the only
naked therapeutic antibody targeti
|SOURCE ARIUS Research Inc.|
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