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ARIUS presents new findings for anti-cancer antibody programs at AACR
Date:4/15/2008

r, prostate cancer as well as AML. The results of the toxicology study support the ongoing development of the of the ARH460-16-2 antibody.

Anti-CD44 antibody, ARH460-16-2, binds to human AML CD34+CD38- cancer stem cells and demonstrates anti-tumor activity in an AML xenograft model. Abstract Number 3976. Experimental and Molecular Therapeutics 32, Tuesday, April 15, 2008, 8:00 AM

This presentation highlights the effects of ARIUS' CD44 targeting antibody, ARH460-16-2, on tumor cells from patients with various hematological cancers, including acute myeloid leukemia (AML). This antibody shows very potent anti-tumor effects in an AML tumor model (57% tumor growth inhibition at a 10 mg/kg compared to control group). In addition the antibody lead to an increase in the median survival to 62 days compared to 49 days in the control group. These results demonstrate that the ARH460-16-2 antibody has the potential for wide therapeutic application in hematological malignancies in addition to its application to the therapy of solid tumors.

ARIUS' ARH460-16-2 antibody is currently being manufactured for human clinical studies. It targets CD44 which is a marker of cancer stem cells in a broad range of solid cancers and AML. The first toxicology studies have been completed for this antibody, and a U.S. FDA pre-IND meeting has been held earlier in the year. This antibody is unique among CD44 antibodies in that it has the capacity to cause tumor regression in established solid tumors. It can directly act on cancer cells to induce apoptosis, or programmed cell death. The antibody may be broadly applicable to solid tumors as well as hematologic cancers.

CD9 Cancer Stem Cell Program

Anti-CD9 antibody, AR40A746.2.3, inhibits tumor growth in pancreatic and breast cancer models and recognizes CD9 on CD34+CD38- leukemic cancer stem cells. Abstract Number 3993. Experimental and Molecular Therapeutics 32, Tuesday, April 15, 2008, 8:00 AM

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7. ARIUS announces manufacturing Agreement with Laureate Pharma For Trop-2 targeting antibody
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