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AQUA® Technology Uses Extend Beyond Protein: Effective measurement of messenger RNA now demonstrated
Date:5/21/2012

BRANFORD, Conn., May 21, 2012 /PRNewswire/ -- HistoRx, the leader in quantitative immunohistochemistry, announces the application of their proprietary AQUA technology to assessment of messenger RNA in tissue.  AQUA technology enables robust quantification and standardization of protein in tissue specimens; this new work extends the platform's capabilities beyond protein expression analysis to quantification of nucleic acids. 

AQUA technology was invented to address the challenges of measuring protein in tissue with the same precision and reproducibility with which laboratories measure glucose in blood.  Human tissue, particularly tumor tissue, is a highly complex environment in which a biomarker's location, quantity and heterogeneity can all be important factors in understanding the biology of the disease.  The ability to use the strengths of AQUA technology to evaluate both protein and RNA allows researchers, for the first time, to explore their relationship within tumor tissue.

Messenger RNA (mRNA) is a nucleic acid that functions as blueprint to translate DNA's genetic code into proteins, the functional units of the cell.  As a biomarker, it enables scientists to evaluate the step between the cell's genetic information and its protein expression.  Assessment of mRNA is usually performed via RT-PCR, a highly sensitive technique that is not easily standardized.  Yale University Professor of Pathology David Rimm, MD, PhD, and his collaborators have taken a new approach, combining AQUAnalysis® from HistoRx with RNAscope® from Advanced Cell Diagnostics, to gain crucial benefits. Dr. Rimm and his collaborators have completed an important study of mRNA by AQUA technology, published in this month's PLoS ONE as "Quantitative In Situ Measurement of Estrogen Receptor mRNA Predicts Response to Tamoxifen."  The study of two independent breast cancer cohorts (n = 128 and n = 524) demonstrate
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