Navigation Links
AMT's Lead Product Poised to Address Major Liver Disease
Date:1/27/2008

AMSTERDAM, The Netherlands, January 28 /PRNewswire-FirstCall/ --

- European Patent Office Grants Patent for Treatment of Non-Alcoholic Steatotic Hepatitis

AMT (Euronext: AMT), a leader in the field of human gene therapy, today announced that the European Patent Office (EPO) has granted the company an important patent for the treatment of Non-Alcoholic Steatotic Hepatitis (NASH) with its lead product AMT-11. AMT has a similar patent pending with the U.S. Patent and Trademark Office.

The most common liver disorder in the Western world, non-alcoholic fatty liver disease (NAFLD), affects 20 to 40 percent of the general population. At least 11 percent of NAFLD patients will develop NASH, a very serious inflammatory liver disease for which there is no therapy and affects many millions in the developed world.

AMT-011, NAFLD, NASH and the metabolic syndrome

AMT-011 is currently in its last phase of clinical development for the treatment of lipoprotein lipase (LPL) deficiency that is associated with very high circulating triglyceride (fat) levels. The product consists of an AAV-based vector that delivers the LPL gene to the muscle, leading to long-term expression of the therapeutic protein, lipoprotein lipase.

The patented invention is related to the observation that expression of AMT-011 in muscle causes a reduction of the liver triglyceride content by redistributing triglycerides from the liver to the peripheral muscles where it is metabolized. NAFLD and NASH are closely related to the pathogenesis of the "metabolic syndrome". This latter condition is characterized by central obesity, increase of serum triglycerides and insulin resistance, and is a major cause of diabetes and coronary vascular disease in the Western world. Recent epidemiological studies published in the journals Gastroenterology and Annals of Hepatology show that the prevalence of NAFLD in the general population is extremely high. Over 60 million adult Ameri
'/>"/>

SOURCE Amsterdam Molecular Therapeutics B.V
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3

Related biology technology :

1. Anesiva Receives FDA Approval for Zingo(TM), a New, Innovative Product to Reduce Pain Associated with Needle Insertion Procedures in Children
2. Angiotech announces additional diameters of sutures to further expand its Quill(TM) SRS PDO product line
3. Barr Confirms Filing an Application With a Paragraph IV Certification for Femcon(R) FE Chewable Oral Contraceptive Product
4. IsoTis Receives FDA Clearance for Accell Family of Products
5. MedImmune Licenses Reverse Genetics Technology to Novartis for Use in Influenza Vaccine Development and Production
6. Heritage and Ipca Enter Into Strategic Alliance for Generic Pharmaceutical Products
7. GenVault Partnership with Genome Quebec Brings $3.3 Million Sale of Dynamic Archive Product
8. ThromboGenics Announces Successful Completion of Technology Transfer to Bharat Biotech for Production of Novel Thrombolytic Agent
9. CODA Genomics Announces Issuance of Optimized Synthetic Gene Production Patent
10. Tutogen Medical, Inc. and Zimmer Holdings, Inc. Announce Agreement for International Distribution of Biological Products
11. Zimmer and Tutogen Announce Agreement for International Distribution of Biological Products
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... JUNCTION, N.J. , Aug. 27, 2014 ... innovative drug delivery technologies, today announced that it has ... Jersey Business & Industry Association,s 2014 Awards for ... were selected by an independent panel of judges from ... company volunteers. Award winners will be honored at a ...
(Date:8/27/2014)... White City, OR (PRWEB) August 27, 2014 ... Supply Report, “Consolidation continues to reshape the look and ... in nutrition. Consumer demand for higher-quality ingredients will push ... the North American market have experienced strong market growth ... and ethical attributes in their food and cosmetics to ...
(Date:8/26/2014)... believe is the thinnest-possible semiconductor, a new class ... atoms thick. , The University of Washington researchers ... materials can be connected in an atomically seamless ... be the basis for next-generation flexible and transparent ... technologies. , "Heterojunctions are fundamental elements of electronic ...
(Date:8/26/2014)... The 20 ambassadors representing the ALS ... issued the following statement on Facebook today regarding the ... new funding specifically for ALS research: , “Who would ... ice would raise all this awareness and funding toward ... on behalf of the entire ALS community, would like ...
Breaking Biology Technology:Tris Pharma Selected as an award winner in the New Jersey Business & Industry Association's 2014 Awards for Excellence 2Daring to be Different Raw Materials & Ingredient Supply Shortage Fuels Vital Force™ Technology New Ingredient Enhancements 2Daring to be Different Raw Materials & Ingredient Supply Shortage Fuels Vital Force™ Technology New Ingredient Enhancements 3Scientists craft atomically seamless, thinnest-possible semiconductor junctions 2ALS TDI’s Young Faces of ALS Ambassadors Thank You for Accepting the Ice Bucket Challenge to End ALS 2ALS TDI’s Young Faces of ALS Ambassadors Thank You for Accepting the Ice Bucket Challenge to End ALS 3ALS TDI’s Young Faces of ALS Ambassadors Thank You for Accepting the Ice Bucket Challenge to End ALS 4
... the Wisconsin Technology Council have released a report detailing ... the difficulties that still need to be addressed to ... ,Wisconsin Technology Council President Tom Still pointed out ... have lost 10 to 15 percent of their technology ...
... study reported in the June 2005 issue of ... predominant. But many companies, even in people businesses, ... need to excel. While organizations have perfected sophisticated ... production and flow of goods and services, their ...
... optimistic that his bill requiring notification of electronic ... year. , ,Senate Bill 164, co-authored by ... require companies that keep personal data on customers ... data is obtained by unauthorized parties. Kanavas said ...
Cached Biology Technology:Report: Wisconsin still lags in college degrees held by workforce, leads elsewhere 2Report: Wisconsin still lags in college degrees held by workforce, leads elsewhere 3Four steps to making talent management a core competence 2Four steps to making talent management a core competence 3Four steps to making talent management a core competence 4Kanavas thinks personal ID theft bill will pass this year 2
(Date:8/27/2014)... of Warwick research finds , Gamblers show the ... new research has shown. , Researchers, led by Dr ... Psychology, conducted tests that found that both human gamblers ... high-value than low-value rewards. , Published in Biology ... show the important role that memories of previous biggest ...
(Date:8/26/2014)... developed algorithms to identify weak spots in tendons, muscles ... which needs to be refined before it is used ... and tiny injuries in the body,s tissues long before ... Aug. 27 in the Journal of the Royal ... of the physical and life sciences. , "Tendons are ...
(Date:8/26/2014)... of Warwick have provided the first evidence that ... linked to early signs of dementia. , Published ... that the absence of the protein MK2/3 promotes ... nervous system. These changes were shown to have ... including restricted learning and memory formation capabilities. , ...
Breaking Biology News(10 mins):Gamblers are greedy bird-brains, University of Warwick research finds 2New technology may identify tiny strains in body tissues before injuries occur 2New technology may identify tiny strains in body tissues before injuries occur 3Lack of naturally occuring protein linked to dementia 2
... Europe,s first personalized treatment for lung cancer heralds the ... that will demand significant changes to the way cancer ... said today at the 2nd European Lung Cancer Conference ... Medical University of Vienna said that personalized therapy, in ...
... first trial of an important new combination therapy of ... in lung cancer has delivered promising results, French researchers ... The results of the Phase I trial suggest ... well-enough tolerated to allow it to be administered at ...
... allows precise targeting of radiotherapy using real-time X-ray images has ... administered to lung and liver cancers while minimizing harm to ... Cancer Conference. "With this study we show that it ... that can give information at any time before or during ...
Cached Biology News:Making personalized lung cancer therapy a reality in Europe 2First trial of pemetrexed with radiation and chemo in lung cancer shows promising results 2
Human monocyte-derived dendritic cells, For immunohistochemistry (IHC) Cell Chip with Human Peripheral Blood Dendritic Cells and EPCs...
...
...
...
Biology Products: