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AMT Provides Business Update for the Third Quarter 2009
Date:11/18/2009

on. AMT employed 88 persons as of September 30, 2009. Total expenses in the third quarter of 2009 were EUR4.4 million compared to EUR4.7 million in the same period last year.

(*) The Company's cash position is composed of cash and cash equivalents.

Material events after September 30, 2009

On November 11, 2009 AMT announced that it has successfully treated Duchenne muscular dystrophy (DMD) in an animal model with its proprietary gene therapy. The proof of concept studies were performed in collaboration with the group of Professor Irene Bozzoni (University of Rome, La Sapienza, Italy) and demonstrated efficacy in the heart as well as in skeletal muscles. In a previous study, AMT's gene therapy approach was shown to be successful in the treatment of diseased human muscle cells obtained from biopsies of DMD patients. These data establish a robust basis for AMT's therapeutic approach to DMD.

The ongoing trial with Glybera(R) for lipoprotein lipase deficient (LPLD) patients in Canada was closed for patient recruitment on October 30, 2009 with 5 patients dosed. AMT is well on track to file for regulatory approval for Glybera(R) within the next three months. The main aim of the ongoing trial is to gain further insight in the mechanism of action of Glybera(R), and data obtained from this trial will further strengthen the Glybera(R) data package that will be filed with the EMEA.

On November 17, 2009, updated safety and efficacy data on Glybera(R) from the first two clinical studies was presented at the meeting of the American Heart Association in Orlando. These data confirm the sizeable decrease in pancreatitis incidence after therapy with Glybera(R) and confirm its excellent safety profile.

On October 29, 2009, AMT and Progenika Biopharma announced that they have entered into a development and commercialization agreement for LPLchipTM, a diagnostic tool to rapidly diagnose patient
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SOURCE Amsterdam Molecular Therapeutics B.V
Copyright©2009 PR Newswire.
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