Navigation Links
AMT Makes Important Advance in the Development of its Gene Therapy for Hemophilia B -Company Accesses Technology to Prevent Immune Response
Date:6/9/2008

AMSTERDAM, The Netherlands, June 10 /PRNewswire-FirstCall/ -- Amsterdam Molecular Therapeutics (Euronext: AMT), a leader in the field of human gene therapy, today announced that it obtained a license from 'TIGET' San Raffaele Telethon Institute For Gene Therapy, Italy, to use their micro-RNA technology to prevent immune responses against gene therapy for Hemophilia B. This technology enables AMT to accelerate the development of AMT-060 (AMT's AAV-based gene therapy for this seriously debilitating disease).

Hemophilia B occurs in 1 in 30,000 males and results in severe internal and external bleeding. The disease is caused by defective blood clotting due to an absence of clotting factor Factor IX. Gene therapy can be used to introduce the gene that produces Factor IX and thereby repair blood clotting. AMT will use the TIGET technology to prevent an immune response against the newly formed Factor IX, which the patient's body may recognize as being foreign.

Formalizing relationship with leading micro-RNA research group of professor Naldini

Ronald Lorijn, CEO of AMT said: "We are very excited to have licenced this groundbreaking technology, which has been shown to prevent immune responses effectively. Access to TIGET's micro-RNA technology perfectly complements our gene therapy approach to cure hemophilia B with a single treatment."

TIGET is very satisfied as this agreement represents an important development of the discoveries made by Prof. Luigi Naldini, Co-Director of TIGET and his collaborator Dr. Brian Brown, and that it will foster further industrial collaborations aimed at moving these innovative solutions from the research to the clinic.

Micro-RNA inhibition

Luigi Naldini and Brian Brown of TIGET have demonstrated in mouse models that naturally occurring micro-RNAs can be exploited to stringently regulate the expression of genes delivered by vectors used in gene therapy.

With this approach expression of the
'/>"/>

SOURCE Amsterdam Molecular Therapeutics B.V
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3

Related biology technology :

1. Web Portal Makes Organ Donation Easy
2. Advanced Cell Technologys Dr. Robert Lanza Makes List of 100 Most Inspiring People in the Life-Sciences Industry
3. NanoLogix Inc. Appoints Director of IP and Makes Progress on Rapid Anthrax Detection
4. Argonne researcher studies what makes quantum dots blink
5. Modifying an anti-cancer drug makes it more specific
6. NanoLogix, Inc. Makes Stock Pick List
7. Pharsight Makes Strong Contribution to Inaugural American Conference on Pharmacometrics
8. CSCs Dr. Robert M. Wah Makes Top 10 in 50 Most Powerful Physician Executives List
9. Cephalon Reinforces Important Prescribing and Dosing Information for FENTORA
10. 454 Sequencing(TM): Science Paper Suggests That Structural Variation Plays an Important Role in Genetic Variation
11. Stem Cell Science Holds Opportunities as Important Tool for Diabetes Research Beyond Cell-Based Treatments
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... N.Y. , Aug. 21, 2014  BioSpecifics ... biopharmaceutical company developing first in class collagenase-based products ... or CCH) in the U.S. and XIAPEX ® ... significant results from a randomized, double-blind Phase 2a ... cellulite, or edematous fibrosclerotic panniculopathy. The results showed ...
(Date:8/21/2014)... at the Institute for Molecular Medicine Finland (FIMM), ... developed a novel "man and machine" decision support ... aid was described in PLOS One ... based on computer vision algorithms similar to those ... of only the diagnostically most relevant areas. Tablet ...
(Date:8/21/2014)... 2014 2014 Deep Research ... a professional and in-depth research report on ... basic Seaweed Fertilizer information, including Seaweed Fertilizer ... as well as industry overview. This research ... market as well as global industry analysis ...
(Date:8/21/2014)... 2014 His Majesty Willem-Alexander, King of ... Court of His Majesty Willem-Alexander, King of the Netherlands, ... Opening of POET-DSM Advanced Biofuels’ Project LIBERTY cellulosic ethanol ... The King will take part in the Grand Opening ... 11 a.m.-12:20 p.m. and tour the plant. POET-DSM is ...
Breaking Biology Technology:BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 2BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 3BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 4BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 5A novel 'man and machine' decision support system makes malaria diagnostics more effective 2Internationals Seaweed Fertilizer Industry 2014 Development Trend Analysis in New Research Study at DeepResearchReports.com 2Internationals Seaweed Fertilizer Industry 2014 Development Trend Analysis in New Research Study at DeepResearchReports.com 3His Majesty Willem-Alexander, King of the Netherlands, to Attend Project LIBERTY opening 2His Majesty Willem-Alexander, King of the Netherlands, to Attend Project LIBERTY opening 3
... With the first observation of thermoelectric effects at ... transistors have a nanoscale cooling effect that reduces their ... William King and electrical and computer engineering professor Eric ... April 3 advance online edition of the journal ...
... conventional optical instruments, light cannot be focused to spot ... effects. An important approach to beat this diffraction ... an allusion to their radiofrequency counterparts. They have the ... nanometer-scale dimensions, which are orders of magnitude smaller than ...
... Diego have produced the first high resolution structure of a ... was published in a paper in this week,s early online ... of Sciences by a team of chemists headed by ... UCSD. The scientists said the ability to carry structural ...
Cached Biology Technology:Self-cooling observed in graphene electronics 2Transmission lines for nanofocusing of infrared light 2Transmission lines for nanofocusing of infrared light 3
(Date:8/21/2014)... international team of scientists including researchers from the University of ... known as canolain the journal Science . Their discovery ... is used widely in farming and industry. , Canola ... but the winter crop is increasingly cultivated in Georgia. Canola ... levels of saturated fat and rich supply of omega-3 fatty ...
(Date:8/21/2014)... use a previously unknown process for harvesting energy and ... a Penn State University scientist has discovered. The discovery ... plant growth, harvesting energy from the Sun, and understanding ... and other lakes worldwide. A paper describing the discovery ... edition of the journal Science on 21 ...
(Date:8/21/2014)... A landmark study aimed at improving the food intake, ... long-term care homes is among three projects at the ... grants from the Canadian Institutes of Health Research (CIHR). ... Applied Health Sciences at Waterloo, and a Schlegel research ... two years to investigate why many Canadians living in ...
Breaking Biology News(10 mins):Canola genome sequence reveals evolutionary 'love triangle' 2Hot-spring bacteria reveal ability to use far-red light for photosynthesis 2Hot-spring bacteria reveal ability to use far-red light for photosynthesis 3Grants will fund landmark aging research at Waterloo 2
... tiny organic aerosols floating in the atmosphere emitted ... characteristics as a group that scientists can generalize their ... The groundbreaking research by Colette Heald, assistant professor in ... was highlighted this month on the cover of the ...
... closely associated with the African savanna -- fierce lions, ... players when it comes to shaping the ecosystem. ... be the termite, say ecologists who,ve found that these ... Kenya via a network of uniformly distributed colonies. Termite ...
... For marine iguanas living in the Galapagos Islands, an ... while others survive. Scientists have long believed that the ... on the animals, ability to secrete the stress hormone ... a spigot by controlling how the body expends energy ...
Cached Biology News:Colorado State University scientist simplifies aerosols for modeling 2The star of Africa's savanna ecosystems may be the lowly termite 2The star of Africa's savanna ecosystems may be the lowly termite 3 Study sheds light on how marine animals survive stress 2
...
p21 Ras Immunogen: Recombinant C-H-ras p21(val-12). Storage: 4 C...
Rabbit polyclonal to Myosin VIIa (rating: *****) ( Abpromise for all tested applications). entrezGeneID: 4647 SwissProtID: Q13402...
Rabbit polyclonal to GPCR G2A ( Abpromise for all tested applications). entrezGeneID: 29933 SwissProtID: Q9UNW8...
Biology Products: