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ALS Therapy Development Institute and Oxford BioMedica Begin Second Phase of Collaboration to Develop Gene Therapies for Amyotrophic Lateral Sclerosis
Date:1/27/2010

CAMBRIDGE, Mass. and OXFORD, England, Jan. 27 /PRNewswire-USNewswire/ -- The ALS Therapy Development Institute and Oxford BioMedica (LSE: OXB) announced today the extension of their collaboration following successful completion of the first phase. The extended collaboration, which is funded by the Muscular Dystrophy Association, aims to advance the development of Oxford BioMedica's preclinical gene therapy candidate, MoNuDin®, and to evaluate other gene-based strategies for the treatment of amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease).

"ALS is a debilitating disease that takes so many of our best and brightest from us without warning and without reason. This collaboration adds yet another important element to our burgeoning drug development pipeline. Gene therapy is a crucial, emerging therapeutic option for diseases such as ALS and Oxford BioMedica has the experience and commitment for excellence needed in a partner,"  said Steven Perrin, Ph.D., Chief Executive Officer and Chief Scientific Officer of the ALS Therapy Development Institute (ALS TDI).

The collaboration combines Oxford BioMedica's advanced LentiVector® gene delivery technology with the ALS TDI's extensive gene expression database and drug screening capabilities. The first phase of the collaboration included the development of new techniques to evaluate and identify gene therapy candidates at the ALS TDI's research facility in Cambridge.

In this second next phase, the ALS TDI will conduct preclinical efficacy studies of Oxford BioMedica's LentiVector-based product, MoNuDin, which is designed to protect the motor neurons susceptible to degeneration from ALS by targeted delivery of the neuroprotective gene, vascular endothelia
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SOURCE ALS Therapy Development Foundation
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