Navigation Links
ALS Therapy Development Institute and Neurimmune Partner to Advance Treatments for ALS
Date:12/6/2013

CAMBRIDGE, Mass., Dec. 6, 2013 /PRNewswire-USNewswire/ -- The ALS Therapy Development Institute (ALS TDI), together with its wholly-owned subsidiary, Anelixis Therapeutics, announced today that it has formed a research partnership with Neurimmune to advance potential treatments for ALS, also known as Lou Gehrig's disease. The research partnership will explore a human monoclonal antibody that targets misfolded superoxide dismutase 1 (SOD1). Misfolded SOD1 accumulates in familial and sporadic ALS, suggesting a generalized role as a drug target for ALS treatments.

(Logo: http://photos.prnewswire.com/prnh/20110204/DC42625LOGO)

"We are excited by the results of Neurimmune's findings," says Steve Perrin, Ph.D., CEO & CSO of ALS TDI. "Recent evidence would suggest that therapies targeting misfolded SOD1 could be important in both sporadic and familial forms of ALS. It is crucial that we use every tool available to us to advance potential treatments toward the clinic, and we are proud to work together with Neurimmune to attempt to do just that."

The collaboration will explore the high-affinity human antibodies developed by Neurimmune that selectively target misfolded SOD1. In preclinical studies with transgenic mice, chronic antibody treatment significantly reduced SOD1 pathology and rescued spinal cord motor neurons, resulting in significantly reduced muscle atrophy, better motor functions and increased survival. Neurimmune will present the key findings of their approach at the International Symposium on ALS/MND Research in Milan, Italy on December 7, 2013.

"ALS is a devastating neuromuscular disease,
'/>"/>

SOURCE ALS Therapy Development Institute
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3

Related biology technology :

1. Gene Therapy - Technologies, Markets and Companies
2. Studies Assess Hydroxyurea Therapy and Pre-Operative Transfusions for Patients with Sickle Cell Disease
3. TrovaGene, Inc. Obtains Exclusive License to Novel Mutations Associated with Prognosis and Chemotherapy Response in Leukemia
4. Amsterdam Molecular Therapeutics Receives US Orphan Designation for Hemophilia B Gene Therapy
5. Squamous Cell Cancer Responds to SPDT Therapy
6. Stem cell therapy reverses diabetes
7. Islet Sciences, Inc. Selects NeoStems Manufacturing Subsidiary Progenitor Cell Therapy for Product Manufacturing
8. UH Case Medical Center Offers New Therapy for Gynecologic Cancer Patients
9. Senior Management of NeoStem and Its Subsidiaries Invited to Speak at Seventh International Conference on Cell Therapy for Cardiovascular Disease
10. Aethlon Medical Establishes Extracorporeal Therapy Scientific Advisory Board
11. BioRestorative Therapies to Present at 7th International Conference on Cell Therapy for Cardiovascular Disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... July 10, 2014 Research and Markets ... the "International Photonic Integrated Circuit (Monolithic Integration, ... 2019" report to their offering. ... concept of photonic integration traces its roots in ... promise of photonic integration went unexplored and unfulfilled ...
(Date:7/10/2014)... April 15, 2014 -- According to the International ... nuclear security comes from terrorists acquiring sufficient quantities ... construct a crude nuclear explosive device. The IAEA ... trafficking have involved gram-level quantities, which can be ... According to a new study appearing this week ...
(Date:7/10/2014)... June 17, 2014 Using microscopic polymer light ... gases, researchers at MIT,s Quantum Photonics Laboratory have ... in the parts-per-billion range. Optical sensors are ideal ... high signal-to-noise ratio, compact, lightweight nature, and immunity ... sensors had been developed before, the MIT team ...
(Date:7/10/2014)... psychiatric disorders has been extremely challenging because there are ... insufficient to cause disease. Now investigators reporting in the ... Cell Stem Cell describe a strategy that may ... other risk factors or environmental exposures to affect the ... genetic variant that may predispose individuals to schizophrenia. ...
Breaking Biology Technology:International Photonic Integrated Circuit (Monolithic Integration, Hybrid Integration, Module Integration) Market - Forecasts to 2019 2Sensitive detection method may help impede illicit nuclear trafficking 2Swell new sensors 2New strategy could uncover genes at the root of psychiatric illnesses 2
... Jan. 14 Shamir,Optical Industry Ltd. (Nasdaq: ... and technology to the progressive ophthalmic lens,market, announced ... a dividend,distribution in an aggregate amount of US$ ... January 11, 2008 representative rate of,exchange), or approximately ...
... HAIKOU, China, Jan. 14 /Xinhua-PRNewswire-FirstCall/ --,China Pharma ... CPHI),which develops, manufactures, and markets generic and ... it has retained,HC International, Inc. (HCI) to ... Matthew Hayden and Alan Sheinwald of HCI, ...
... Today, The Woodbridge Group announced,the most ... highest,levels of "Green" Polyurethane Foams. As a ... a patented technology, substitutes petroleum,with plant oils, ... solution for a full line-up of automotive ...
Cached Biology Technology:Shamir Optical Industry Ltd. Announces Declaration of a Cash Dividend 2Shamir Optical Industry Ltd. Announces Declaration of a Cash Dividend 3China Pharma Holdings, Inc. Retains HC International, Inc. to Implement Investor Relations Program 2China Pharma Holdings, Inc. Retains HC International, Inc. to Implement Investor Relations Program 3Woodbridge Offers the Broadest Range of BioFoam(TM) 'Green' Polyurethane Automotive Interior Applications 2
(Date:7/10/2014)... -- Fingerprint Cards, (FPC,s) new mobile touch sensor ... Chinese Top 5 smartphone OEM has selected FPC1021 for a ... October 2014.   FPC is proud to announce ... has a planned date for the start of mass production ... phone of 3 million units. The Chinese OEM wants to ...
(Date:7/10/2014)... , July 8, 2014 ... won a new design win (DW). An Asian OEM has ... for mass production start in August 2014.   ... smartphone OEM, which has a planned date for start of ... initial ramp order of SEK 5M, for delivery in the ...
(Date:7/10/2014)... July 9, 2014 The widespread adoption ... large part by meaningful use and related federal ... interact with laboratory information. Now, more than ever, ... of clinical informatics in order to deliver high ... address the educational needs of pathologists in this ...
Breaking Biology News(10 mins):FPC Wins DW for 1021 Touch Sensor for Flagship Smartphone from Chinese Top 5 Smartphone OEM 2FPC Wins DW and Initial Ramp Order for FPC1021 Touch Sensor for Flagship Smartphone from Asian OEM 2New Clinical Informatics Curriculum Prepares Future Pathologists 2New Clinical Informatics Curriculum Prepares Future Pathologists 3New Clinical Informatics Curriculum Prepares Future Pathologists 4
... for early diagnosis of Alzheimers, Parkinsons and other diseases ... New Jersey Technology Council competition. Based at NJITs ... www.neurotrax.com , a start-up company, was named most likely ... 500 entrepreneurs and investors. NeuroTrax ...
... an essential chemical communicator, carrying impulses from neurons ... the nervous system. Now researchers at the University ... a key component of the relay system that ... findings, which appear in the current issue of ...
... The Global Innovation Imperatives (Gii) project swung into ... session at the American Chemical Societys (ACS) 235th ... collaboration between the ACS Committee on Corporation Associates ... combat worldwide health, environmental and societal issues by ...
Cached Biology News:NJIT start-up company NeuroTrax named best in show 2Researchers 'see' structure of open nicotinic acetylcholine ion channels 2Researchers 'see' structure of open nicotinic acetylcholine ion channels 3At ACS' national meeting, global initiative set to tackle water issues 2
Takara's Mutan-Super Express Km Kit is designed to achieve site-directed mutagenesis in just one day. It is based on Oligonucleotide-directed Dual Amber (ODA) method, using the advantages of LA (Long...
... TriEx Sf9 Cells and TriEx Insect ... from pTriEx baculovirus constructs. This cell/medium combination ... cell growth and high protein expression levels ... pTriEx-1.14 vectors. Please note that our Ready-Plaque ...
...
...
Biology Products: