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AFFiRiS AG: Atherosclerosis Vaccine Development Receives EU Support
Date:5/27/2009

VIENNA, Austria, May 27 /PRNewswire/ -- The atherosclerosis vaccine development program by AFFiRiS AG is receiving financial support from the EU's EUROTRANS-BIO call. The respective project is being carried out in cooperation with German company EMC microcollections GmbH. The aim of atherosclerosis vaccination is to increase the amount of "good" high density lipoprotein cholesterol (HDLc) in the blood and thus reduce the occurrence of harmful fatty deposits in the arteries. Product candidates were delivered by AFFiRiS' AFFITOME(R) platform technology. The target is a protein known as CETP (cholesteryl ester transfer protein). Following vaccines for Alzheimer's disease and Parkinson's disease, the atherosclerosis vaccine is the third such project announced by AFFiRiS AG.

Vienna-based AFFiRiS AG today announced that its atherosclerosis vaccine development program is receiving support from the EU's EUROTRANS-BIO call. The supported project - known as CETP Vaccine (ETB-2008-28) - is based on the AFFITOME(R) technology of AFFiRiS AG and is being conducted together with EMC microcollections GmbH from Tubingen, Germany. The urgent need for an effective strategy against atherosclerosis is clearly evident from the relevant figures - diseases of the cardiovascular system are the number one cause of death in Europe and the US. In Europe, this is at the root of almost 50 % of all deaths. One of the primary causes of cardiovascular disease is atherosclerosis, a narrowing of key arteries due to fatty deposits. Although there are options for medication-based intervention in the form of statins, these are deemed to be of limited effectiveness despite some notable successes.

CSO Dr. Frank Mattner explains: "Today's therapies with Statins act on low density lipoprotein cholesterol (LDLc) and reduce its concentration in the blood. This type of treatment can reduce the likelihood of severe heart disease by as little as 30
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SOURCE AFFiRiS AG
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