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AFCell Medical Reports Results from the Retrospective Study of a Novel Allograft Membrane to Prevent Post-Operative Adhesions in the Repair of Peroneal and Posterior Tibial Tendons
Date:9/4/2012

dhesions caused severe limitation in motion, and none were associated with pain upon range of motion.

Statistical analysis was performed to determine if these changes were statistically significant. Prior to surgery, the average FFI was 123.2 (SD=22.3), as compared to 91.0 (SD=40.7). The difference was strongly significant with p=0.003. The average BFS prior to surgery was 55.4 (SD=13.8), and the BFS after surgery was 45.4 (SD=16.2). This difference was also statistically significant with p=0.012.

Discussion

This retrospective study regarding the use of amniotic membranes as transplants to restore natural sheathing or covering between the tendon, peritendonous structures, and overlying skin in order to help prevent post-operative adhesions at the surgery site generated data which is generally consistent with prior animal studies of amniotic membranes as transplants to help prevent post-operative adhesions.

In the canine laminectomy model (Tao, Fan: Implantation of amniotic membrane to reduce postlaminectomy epidural adhesions; European Spine Journal: 2009, Published online) crosslinked amnion membranes (CAM) were used to help prevent post-operative adhesions. In that study, animals treated with amnion were observed to have a much weaker or nearly absent epidural adhesion. The white, slightly vascularized membrane was found between the dura matter and surrounding tissues to reduce scar intrusion. Furthermore, the CAM layer seldom adhered to the dura mater and was easily removed. Only a layer of fibrous tissue could be found between the CAM layer and dura mater in three samples [out of 24 total]. Of those animals with adhesions, the adhesions were mild and histologies of those adhesions showed that they were highly disorganized.

Amniotic membrane tissues are comprised of collagen type III, I, IV, V and VI and contain native and endogenous proteins and peptides. The structure and function of amniotic tissues is nearly id
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