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AEterna Zentaris to Further Develop Three Follow-up Multi-targeted Cytotoxic Candidates to AEZS-112 as Potential Novel Cancer Treatment
Date:10/25/2007

with clonogenic growth of human xenograft derived cell lines.

Conclusions

- All three AEZS-112 follow-up candidates were equal to or more efficient

in exerting cytotoxic activity in tumor cell lines and inhibiting

tubulin polymerization than AEZS-112, whereas induction of cell cycle

arrest and apoptosis was slightly improved;

- An interesting difference to the AEZS-112 profile is the inhibition of

topoisomerase I by compounds 2 and 3. Moreover, compound 2 displayed

significant higher potency for topoisomerase II inhibition than

AEZS-112;

- In vitro plasma and liver microsomal stability of the follow-up

candidates are comparable to AEZS-112, thus demonstrating suitability

for in vivo efficacy studies;

- Interference with clonogenic growth of xenograft-derived cells revealed

variability in the response of the different tumor classes to AEZS-112

and compound 1 treatment as a basis for selection of the most

appropriate in vivo efficacy models.

Based on their interesting in vitro profiles, all three follow-up candidates will be subjected to human tumor xenograft in vivo models aimed at selecting an AEZS-112 follow-up candidate for preclinical development.

The poster presentation is available in the Investor section of the Company's website under "Events and Webcasts" at http://www.aeternazentaris.com.

About AEZS-112

AEZS-112 is a novel oral multi-targeted cytotoxic compound with inhibitory effects on tubulin polymerization, topoisomerase II and angiogenesis. In January 2007, the Company initiated a Phase 1 clinical trial for solid tumors and lymphoma; primary endpoints will focus on determining the safety and tolerability of the compound.

AEZS-112 has shown potent in vitro anti-proliferative activity at nanomolar concentrations against human tumor cell lines of diff
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SOURCE AETERNA ZENTARIS INC.
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