Navigation Links
AEterna Zentaris to Further Develop Three Follow-up Multi-targeted Cytotoxic Candidates to AEZS-112 as Potential Novel Cancer Treatment
Date:10/25/2007

New In Vitro Data presented at AACR-NCI-EORTC International Conference on

Molecular Targets and Cancer Therapeutics in San Francisco

QUEBEC CITY, Oct. 25 /PRNewswire-FirstCall/ - AEterna Zentaris Inc. (TSX: AEZ; Nasdaq: AEZS), a global biopharmaceutical company focused on endocrine therapy and oncology, today presented an abstract outlining novel data generated from three AEZS-112 (formerly ZEN-012) follow-up multi-targeted cytotoxic candidates at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics being held this week at the Moscone Convention Center in San Francisco, California. Following encouraging results, the Company will pursue further research aimed at selecting an AEZS-112 follow-up candidate for preclinical development in cancer.

David J. Mazzo, Ph.D., President and Chief Executive Officer at AEterna Zentaris commented, "These encouraging new results for our AEZS-112 follow-up compounds are further proof of the quality and depth of our internal drug discovery engine, and we look forward to the continued development of these compounds as potential novel oral cancer treatments."

Results

The abstract #C218 entitled, "Highly Potent Cytotoxic Compounds with Inhibitory Effects on Tubulin Polymerization and Topoisomerase II", reviewed results of a pharmacological characterization of three follow-up compound candidates to AEZS-112, AEterna Zentaris' multi-targeted cytotoxic compound currently in a Phase 1 clinical trial for solid tumors and lymphoma. The analysis was aimed at identifying compounds with either quantitative or qualitative variations in either mode of action - inhibition of tubulin polymerization, topoisomerase activity as well as antiangiogenic properties - and/or tumor specificity for subsequent preclinical development.

AEZS-112 follow-up candidates were subjected to comprehensive in vitro profiling with respect to mode of action, metabolic stability and interference with clonogenic growth of human xenograft derived cell lines.

Conclusions

- All three AEZS-112 follow-up candidates were equal to or more efficient

in exerting cytotoxic activity in tumor cell lines and inhibiting

tubulin polymerization than AEZS-112, whereas induction of cell cycle

arrest and apoptosis was slightly improved;

- An interesting difference to the AEZS-112 profile is the inhibition of

topoisomerase I by compounds 2 and 3. Moreover, compound 2 displayed

significant higher potency for topoisomerase II inhibition than

AEZS-112;

- In vitro plasma and liver microsomal stability of the follow-up

candidates are comparable to AEZS-112, thus demonstrating suitability

for in vivo efficacy studies;

- Interference with clonogenic growth of xenograft-derived cells revealed

variability in the response of the different tumor classes to AEZS-112

and compound 1 treatment as a basis for selection of the most

appropriate in vivo efficacy models.

Based on their interesting in vitro profiles, all three follow-up candidates will be subjected to human tumor xenograft in vivo models aimed at selecting an AEZS-112 follow-up candidate for preclinical development.

The poster presentation is available in the Investor section of the Company's website under "Events and Webcasts" at http://www.aeternazentaris.com.

About AEZS-112

AEZS-112 is a novel oral multi-targeted cytotoxic compound with inhibitory effects on tubulin polymerization, topoisomerase II and angiogenesis. In January 2007, the Company initiated a Phase 1 clinical trial for solid tumors and lymphoma; primary endpoints will focus on determining the safety and tolerability of the compound.

AEZS-112 has shown potent in vitro anti-proliferative activity at nanomolar concentrations against human tumor cell lines of different origin. The compound is active in tumor cell lines which are resistant to cisplatin and doxorubicin as well as to tubulin inhibitors such as vincristine and paclitaxel. Given orally once or twice weekly, AEZS-112 proved to be a potent inhibitor of in vivo tumor growth in different models including mammary, colon, skin, lung, renal and leukemic cancers.

About AEterna Zentaris Inc.

AEterna Zentaris Inc. is a global biopharmaceutical company focused on endocrine therapy and oncology with proven expertise in drug discovery, development and commercialization.

News releases and additional information are available at http://www.aeternazentaris.com

Forward-Looking Statements

This press release contains forward-looking statements made pursuant to the safe harbor provisions of the U.S. Securities Litigation Reform Act of 1995. Statements that are not historical facts, including statements preceded by, followed by, or that include the words "believes", "anticipates", "intends", "plans", "expects", "estimates", "will," "may", "should", "approximately", and the negative or other variations of those terms or comparable terminology, are forward-looking statements. Such statements reflect management's current views, intentions, strategies and plans and are based on certain assumptions.

Forward-looking statements involve known and unknown risks and uncertainties, which could cause the Company's actual results to differ materially from those in the forward-looking statements. Such risks and uncertainties include, among others, the ability of AEterna Zentaris to implement its business strategies, the availability of funds and resources to pursue R&D projects, the successful and timely completion of clinical studies, the ability of AEterna Zentaris to take advantage of business opportunities in the pharmaceutical industry, uncertainties related to the regulatory process and general changes in economic conditions. Investors should consult the Company's quarterly and annual filings with the Canadian and U.S. securities commissions for additional information on risks and uncertainties relating to the forward-looking statements. Investors are cautioned not to rely on these forward-looking statements. The Company does not undertake to update these forward-looking statements at http://www.aeternazentaris.com.


'/>"/>
SOURCE AETERNA ZENTARIS INC.
Copyright©2007 PR Newswire.
All rights reserved

Related biology technology :

1. A Further Step in Understanding Apoptosis Direct Detection of PARP Cleavage
2. OpGen recruits CEO to further gene-mapping business
3. Better collaboration urged to further Wisconsin biotech
4. Johnson Controls jumping further into hybrid-vehicle battery world
5. The let-7 microRNA Family Regulates RAS: Implications for Development and Oncogenesis
6. RNArticles: RNA Amplification Used to Develop a New In Vitro HCMV Assay
7. Rapid Method Development With the BioLogic DuoFlow Chromatography System for the Purification of His-Tagged Proteins
8. A Multiple Mutation Model System as a Test Development and Training Tool for Denaturing Gradient Gel Electrophoresis
9. Development of a Multiplex Bead-Based Assay for Antibody Screening of a Nonhuman Primate Colony on the Bio-Plex System
10. The development of a CXCR2 chemokine receptorbinding assay using the LEADseeker Multimodality Imaging System
11. The development of a melanocortin MC4 receptor binding assay using the LEADseeker Multimodality Imaging System
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/4/2016)... ... May 04, 2016 , ... PBI-Gordon Corporation is pleased to ... , Doug began his career at PBI-Gordon in February 1988, after finishing his ... variety of roles, ranging from customer service to national product manager, to helping develop, ...
(Date:5/3/2016)... ... May 03, 2016 , ... In a list published by the Boston ... 76 fastest-growing private companies; a small percentage of the state's 615,000+ small businesses. The ... percent change in revenue from 2012 to 2015. , As this award ...
(Date:5/3/2016)... ... 03, 2016 , ... Wearable Tech + Digital Health ... take place on June 7-8, 2016, at the New York Academy of Sciences.  , ... -- including AR/VR, machine learning, apps, robotics and AI -- throughout a major health ...
(Date:5/3/2016)... ... May 03, 2016 , ... Nashville ... IVF laboratories. A contingency of reproductive endocrinologists, including Dr. George Hill ... infertility and to help them build families. , Ovation Fertility is a nationwide ...
Breaking Biology Technology:
(Date:3/31/2016)... 31, 2016   ... the "Company") LegacyXChange is excited to release ... soon to be launched online site for trading 100% ... ) will also provide potential shareholders a sense of ... to an industry that is notorious for fraud. The ...
(Date:3/23/2016)... March 23, 2016 ... Sicherheit Gesichts- und Stimmerkennung mit Passwörtern ... (NASDAQ: MESG ), ein führender Anbieter ... Unternehmen mit SpeechPro zusammenarbeitet, um erstmals dessen ... wird die Möglichkeit angeboten, im Rahmen mobiler ...
(Date:3/21/2016)... March 22, 2016 Unique ... passcodes for superior security   ... provider of secure digital communications services, today announced it ... and offer enterprise customers, particularly those in the Financial ... and voice authentication within a mobile app, alongside, and ...
Breaking Biology News(10 mins):