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AEterna Zentaris to Further Develop Three Follow-up Multi-targeted Cytotoxic Candidates to AEZS-112 as Potential Novel Cancer Treatment
Date:10/25/2007

New In Vitro Data presented at AACR-NCI-EORTC International Conference on

Molecular Targets and Cancer Therapeutics in San Francisco

QUEBEC CITY, Oct. 25 /PRNewswire-FirstCall/ - AEterna Zentaris Inc. (TSX: AEZ; Nasdaq: AEZS), a global biopharmaceutical company focused on endocrine therapy and oncology, today presented an abstract outlining novel data generated from three AEZS-112 (formerly ZEN-012) follow-up multi-targeted cytotoxic candidates at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics being held this week at the Moscone Convention Center in San Francisco, California. Following encouraging results, the Company will pursue further research aimed at selecting an AEZS-112 follow-up candidate for preclinical development in cancer.

David J. Mazzo, Ph.D., President and Chief Executive Officer at AEterna Zentaris commented, "These encouraging new results for our AEZS-112 follow-up compounds are further proof of the quality and depth of our internal drug discovery engine, and we look forward to the continued development of these compounds as potential novel oral cancer treatments."

Results

The abstract #C218 entitled, "Highly Potent Cytotoxic Compounds with Inhibitory Effects on Tubulin Polymerization and Topoisomerase II", reviewed results of a pharmacological characterization of three follow-up compound candidates to AEZS-112, AEterna Zentaris' multi-targeted cytotoxic compound currently in a Phase 1 clinical trial for solid tumors and lymphoma. The analysis was aimed at identifying compounds with either quantitative or qualitative variations in either mode of action - inhibition of tubulin polymerization, topoisomerase activity as well as antiangiogenic properties - and/or tumor specificity for subsequent preclinical development.

AEZS-112 follow-up candidates were subjected to comprehensive in vitro profiling with respect to mode of action, metabolic stability and interference
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SOURCE AETERNA ZENTARIS INC.
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