Navigation Links
AEterna Zentaris to Complete Phase 3 Clinical Trial of Macimorelin (AEZS-130) as First Oral Diagnostic Test for Growth Hormone Deficiency
Date:10/19/2009

QUEBEC CITY, Oct. 19 /PRNewswire-FirstCall/ - AEterna Zentaris Inc. (NASDAQ: AEZS; TSX: AEZ) (the "Company"), a global biopharmaceutical company focused on endocrine therapy and oncology, today announced that it has initiated activities intended to complete the clinical development of the growth hormone secretagogue (GHS) / ghrelin agonist compound macimorelin (AEZS-130) which could be the first oral diagnostic test approved for growth hormone deficiency (GHD). Macimorelin is the International Non-proprietary Name (INN) designated for the compound by the World Health Organization (WHO).

AEterna Zentaris has already assumed the sponsorship of the Investigational New Drug application (IND) and is discussing with the FDA the best way to complete the ongoing Phase 3 clinical trial, and subsequently file a New Drug Application (NDA) for approval of macimorelin (AEZS-130) as a diagnostic test for GHD in adults.

The Phase 3 clinical trial of macimorelin (AEZS-130), to establish it as a diagnostic test for GHD in adults, was initiated in the USA by AEterna Zentaris' former licensee, Ardana Biosciences Ltd. (Ardana); however, the trial was suspended before completion because of Ardana's insolvency. Additionally, AEterna Zentaris regained all rights and acquired all assets related to macimorelin (AEZS-130) as a result of the insolvency process.

The pivotal Phase 3 trial (listed in clinicaltrials.gov, study #NCT00448747) is designed to investigate the safety and efficacy of the oral administration of macimorelin (AEZS-130) as a growth hormone stimulation diagnostic test compared to GHRH + L-arginine, administered intravenously. Currently available results from this study, previously reported by G. Merriam et al. (Poster P2-749, ENDO '09, June 2009), demonstrated no safety issues and better discrimination between adult GHD patie
'/>"/>

SOURCE AETERNA ZENTARIS INC.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3

Related biology technology :

1. AEterna Zentaris completes management team with the appointment of Chief Medical Officer
2. AEterna Zentaris to Present at Upcoming UBS Global Life Sciences Conference in New York
3. AEterna Zentaris Announces Outcome of Managements Strategic Review
4. AEterna Zentaris to Further Develop Three Follow-up Multi-targeted Cytotoxic Candidates to AEZS-112 as Potential Novel Cancer Treatment
5. AEterna Zentaris Reports First Patients Treated with Anti-Cancer Compound AEZS-108 in Phase 2 Trial in Ovarian and Endometrial Cancers
6. AEterna Zentaris to Present at the Upcoming Roth Capital Partners 20th Annual OC Growth Stock Conference in Dana Point, California
7. Aeterna Zentaris to Announce Fourth Quarter and Full-Year 2007 Financial and Operating Results on March 5, 2008
8. AEterna Zentaris Announces the Departure of SVP, Administrative and Legal Affairs
9. AEterna Zentaris and Paladin Labs Announce Sale and Purchase of Miltefosine Rights
10. Aeterna Zentaris Reports Fourth Quarter and Full-Year 2007 Financial and Operating Results
11. Aeterna Zentaris Begins Second Phase 3 Trial of Cetrorelix for Benign Prostatic Hyperplasia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/29/2014)... 29, 2014 Research and Markets  has ... Gas Analyzer, and Gas Chromatograph Market by Type , ... Global Trends & Forecast to 2013 - 2020" ... analyzer is a process analytical instrument that provides chemical ... redefined the way by which companies carry out their ...
(Date:9/29/2014)... CA (PRWEB) September 29, 2014 ... at Yale University the 2014 iCELLigence Research Grant ... studies. ACEA’s iCELLigence instrument is an impedance based ... Ph.D. candidate in Department of Biomedical Engineering at ... Fellowship. Chen’s research projects in Professor Rong ...
(Date:9/29/2014)... Sept. 29, 2014 /PRNewswire/ - SQI Diagnostics Inc. (TSX-V: ... and commercializes proprietary technologies and products for advanced microarray ... Peter Winkley to Chairman of the Board of ... Ricks will continue to serve as a Director on ... the Company.  "We are very pleased ...
(Date:9/29/2014)... , Sept. 29, 2014  The 12th Cold ... officially kicks off September 29 at the John B. ... Boston for a weeklong conference ... Chain Global Forum is designed to cover the industry,s ... modern cold chain, all temperature range products, GDP compliance ...
Breaking Biology Technology:Global Process Liquid Analyzer, Gas Analyzer, and Gas Chromatograph (PH/ORP, Chlorine, Oxygen, Carbon dioxide) Market - Trends & Forecast to 2020 2Global Process Liquid Analyzer, Gas Analyzer, and Gas Chromatograph (PH/ORP, Chlorine, Oxygen, Carbon dioxide) Market - Trends & Forecast to 2020 3Global Process Liquid Analyzer, Gas Analyzer, and Gas Chromatograph (PH/ORP, Chlorine, Oxygen, Carbon dioxide) Market - Trends & Forecast to 2020 4ACEA Biosciences, Inc. Awards Yale University Researcher the iCELLigence Research Grant 2SQI Diagnostics Announces New Chairman of Board of Directors 212th Cold Chain GDP & Temperature Management Logistics Global Forum Officially Kicks Off in Boston 2
... up by 48% at EUR958 Million - EBITDA Margin ... the Target Segment of Pharmaceutical Plastics,in South America: Brazilian ... to provisional figures, Gerresheimer AG has just completed,another record ... up by,48.1%; the adjusted Group EBITDA margin reached 19%. ...
... think a lot about "Homeland Security," but one Montana ... home gardeners also serves to keep us safe from ... the Bozeman campus recently received a five-year grant for ... the lab provides an early warning system of biological ...
... manufactured product our clothes, money, appliances, the paint ... cars will be embedded with intelligence, networks of ... dust or an Internet of Things. The world of ... have surveillance systems, biometrics, personal communicators, machine learning and ...
Cached Biology Technology:2007 Another Record Year in Terms of Sales and Earnings for Gerresheimer 22007 Another Record Year in Terms of Sales and Earnings for Gerresheimer 3Montana State University lab gives early warnings about biological invaders 2Montana State University lab gives early warnings about biological invaders 3Supportive devices or unnecessary surveillance? 2
(Date:9/29/2014)... at home should use ventilation when cooking with a ... after a new study showed an association between gas ... bronchitis. , "In homes where a gas stove was ... is higher than in homes where a gas stove ... professor in the College of Public Health and Human ...
(Date:9/29/2014)... Scientists at Washington State University have concluded that ... apples may help prevent disorders associated with ... to assess these compounds in apple cultivars grown ... edition of the journal Food Chemistry ., ... good source of these nondigestible compounds but there ...
(Date:9/29/2014)... in Behavioral Brain Research provides novel insight ... result of chronic alcohol exposure that can lead to ... and research indicate that individuals with alcohol use disorders ... when people are actively drinking, when they are going ... "Sleep-wake disturbances can last for months, or even years, ...
Breaking Biology News(10 mins):Childhood asthma linked to lack of ventilation for gas stoves, OSU study shows 2Childhood asthma linked to lack of ventilation for gas stoves, OSU study shows 3An apple a day could keep obesity away 2
... Using a systems biological analysis of genome-scale data ... of researchers identified that the master gene controlling ... The study will appear in the latest issue ... Sciences. This hypothesis derived from multi-network analysis of ...
... led by Mark Hoddle , a biological control ... glassy-winged sharpshooter , a major agricultural pest, from the ... in the South Pacific Ocean. To achieve total pest ... that provides permanent control and can be applied to ...
... MANHATTAN, KAN. -- To understand how nitrogen accumulates in large ... Dodds looked at small streams flowing closer to home. ... have to look any farther than his own campus for ... nine small waterways in the Manhattan area that Dodds used ...
Cached Biology News:Systems biology approach identifies nutrient regulation of biological clock in plants 2UCR-led research team uses tiny wasp to wipe out major agricultural pest in Tahiti 2UCR-led research team uses tiny wasp to wipe out major agricultural pest in Tahiti 3UCR-led research team uses tiny wasp to wipe out major agricultural pest in Tahiti 4Research team finds that microorganisms filter nitrogen from small streams 2
... Peptide Antigen Design , Customer Peptide Synthesis , ... purity above 90%, 20 mg will be returned to customer conjugation ... 2, , Maintenance 102 days/each ... injections x5 /each , Test bleed (app. ...
...
GeneRacer is an advanced RACE (rapid amplification of cDNA ends) technique that improves the efficiency of amplifying full-length 5' and 3' cDNA ends. With the GeneRacer Kit you can:...
One-step, microplate or cuvet, colorimetric, linear detection range 0.6 mM to 100 mM. Procedure: 2 min....
Biology Products: