Navigation Links
AEterna Zentaris Presents Two Posters on its PI3K Inhibitor Compound, AEZS-126, at AACR Annual Meeting
Date:4/21/2009

In Vitro and In Vivo Data Show AEZS-126 as Promising Oral Compound for

Future Clinical Development in Cancer

QUEBEC CITY, April 21 /PRNewswire-FirstCall/ - AEterna Zentaris Inc. (TSX: AEZ; NASDAQ: AEZS), a global biopharmaceutical company focused on endocrine therapy and oncology, today presented two posters on AEZS-126, a promising compound for clinical intervention of the PI3K/ Akt pathway in human tumors. The posters were presented at the American Association for Cancer Research (AACR) Annual Meeting in Denver, Colorado.

Poster #3705

Entitled, "AEZS-126, a new orally bioavailable PI3K inhibitor with antitumor effects", I. Seipelt, S. Baasner, M. Gerlach, M. Teifel, J. Fensterle, L. Blumenstein, G. Mueller and E. Guenther, the poster focuses on ADMET and safety profiling of the compound, as well as in vivo pharmacokinetic experiments and mouse xenograft antitumor studies.

Results

AEZS-126 was identified as a potent inhibitor of class I PI3Ks in biochemical and cellular assays and demonstrated favorable properties in early in vitro ADMET screening including microsomal stability, plasma stability and screening against a large safety profile composed of receptors, enzymes and cardiac ion-channels. During the course of in vivo pharmacokinetic experiments and mouse xenograft antitumor studies, the oral bioavailability in mice was determined to be about 60%, leading to micromolar plasma levels which are well above the nanomolar IC50 values in in vitro studies. Significant antitumor activity was observed at 30mg/kg daily oral administration in Hct116 and A549 models.

Conclusion

These data suggest that AEZS-126 is a promising compound for clinical intervention of the PI3K/Akt pathway in human tumors.

Poster #3706

'/>"/>
SOURCE AETERNA ZENTARIS INC.
Copyright©2009 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3

Related biology technology :

1. AEterna Zentaris completes management team with the appointment of Chief Medical Officer
2. AEterna Zentaris to Present at Upcoming UBS Global Life Sciences Conference in New York
3. AEterna Zentaris Announces Outcome of Managements Strategic Review
4. AEterna Zentaris to Further Develop Three Follow-up Multi-targeted Cytotoxic Candidates to AEZS-112 as Potential Novel Cancer Treatment
5. AEterna Zentaris Reports First Patients Treated with Anti-Cancer Compound AEZS-108 in Phase 2 Trial in Ovarian and Endometrial Cancers
6. AEterna Zentaris to Present at the Upcoming Roth Capital Partners 20th Annual OC Growth Stock Conference in Dana Point, California
7. Aeterna Zentaris to Announce Fourth Quarter and Full-Year 2007 Financial and Operating Results on March 5, 2008
8. AEterna Zentaris Announces the Departure of SVP, Administrative and Legal Affairs
9. AEterna Zentaris and Paladin Labs Announce Sale and Purchase of Miltefosine Rights
10. Aeterna Zentaris Reports Fourth Quarter and Full-Year 2007 Financial and Operating Results
11. Aeterna Zentaris Begins Second Phase 3 Trial of Cetrorelix for Benign Prostatic Hyperplasia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/21/2013)... 21, 2013 Smarter Security, Inc., provider ... today announced that Genzyme, a Sanofi company and leading ... Detective® CL for a multi-use facility in the United ... other Genzyme buildings, this latest order underscores the satisfaction ... tailgate detection device improving doorway access control. ...
(Date:5/21/2013)... FL (PRWEB) May 21, 2013 Many ... breakouts as contributor to acne. Recently physicians from ... of mental stress on the skin, and suggested using ... help reduce the chemicals produced from stress that cause ... from the negative feelings acne brings about, stress causes ...
(Date:5/21/2013)... 21, 2013  Synthetic Biologics, Inc. (NYSE MKT: SYN), a ... serious infectious diseases, announced today that Jeffrey Riley ... Annual Marcum LLP MicroCap Conference on Thursday, May 30, 2013 ... Grand Hyatt Hotel. Mr. Riley is scheduled to present at ... Synthetic Biologics, presentation can be accessed by logging onto the ...
(Date:5/21/2013)... Revolutionary Science, the manufacturer of the ... today that they have expanded their colony counter product ... IntelliCount, InCount and ImpressCount. These affordable colony counters ... in food microbiology and pharmaceutical manufacturing. , The previously ... A bright white enclosure with jet black accents represent ...
Breaking Biology Technology:Door Security at Genzyme, a Sanofi Company, Enhanced with Door Detective from Smarter Security 2Door Security at Genzyme, a Sanofi Company, Enhanced with Door Detective from Smarter Security 3Adult Acne Treatment, Probiotic Action Explains How Hypnotherapy and Probiotics May Cure Various Skin Conditions 2Synthetic Biologics to Present at the 2nd Annual Marcum LLP MicroCap Conference 2Revolutionary Science Announces New Automatic and Manual Colony Counting Products 2
... Feb. 12 CORD:USE Cord Blood Bank,is proud to ... Johnson has joined its team. "We,re honored to have ... Dr. Edward,Guindi, President and CEO of CORD:USE. Jimmie Johnson ... Win the Race for Life(TM)",campaign., "I,m excited about ...
... Pickering Resigns from the Board of Directors, NEW ... of K. Tucker Andersen as a director of the ... is a retired,portfolio manager and security analyst and the ... The Company also announced that on,February 1, 2008, Larry ...
... AMT), a leader in the field of human ... financial results for the full,year 2007 on Wednesday, ... Time,(CET). To discuss these results, the Company will ... Dial In: 0800-949-4517 (toll free); US Dial In:,+1-866-291-4166 ...
Cached Biology Technology:Two-time Defending NASCAR Sprint Cup Series Champion Jimmie Johnson Joins the Team at CORD:USE Cord Blood Bank to Help Win the Race for Life 2PeriCor Therapeutics Appoints K. Tucker Andersen to Board of Directors 2
(Date:5/20/2013)... resistant to the antibiotic colistin are also commonly ... body, according to a study in mBio ... Society for Microbiology. Cross-resistance to colistin and host ... body against bacterial attack, could mean that patients ... with a crippled immune response. Colistin is a ...
(Date:5/20/2013)... lungs of the planet, inhales carbon dioxide as it exudes ... parts that eventually fall to the ground to decompose or ... Until recently people believed much of the rain forest,s carbon ... the ocean. University of Washington research showed a decade ago ... left open the question of how that was possible, since ...
(Date:5/20/2013)... A novel vaccine study from South Dakota State ... be unveiled at the American Association of Pharmaceutical Scientists, ... Monday, May 20 - Wednesday, May 22 at the ... main goal of a vaccine is to stimulate the ... the disease", explained Dr. Hemachand Tummala, assistant professor of ...
Breaking Biology News(10 mins):Resistance to last-line antibiotic makes bacteria resistant to immune system 2Resistance to last-line antibiotic makes bacteria resistant to immune system 3Amazon River exhales virtually all carbon taken up by rain forest 2Amazon River exhales virtually all carbon taken up by rain forest 3Germ-fighting vaccine system makes great strides in delivery 2
... Eye Research Institute, an affiliate of Harvard Medical School, ... with retinal and other eye disease to keep track ... published in this weeks PLoS ONE (October 24, 2007) ... the induced twinkle after-effect (TAE) can accurately identify the ...
... syndrome are more likely than their unaffected siblings to ... according to pediatric researchers. The hormone, leptin, may contribute ... and adults with Down syndrome. A research team ... of Pennsylvania School of Medicine published their study online ...
... of Hurricane Katrina on soil quality and agriculture? How can ... extent can biofuels help make America energy independent? These topics ... International Annual Meetings of the American Society of Agronomy (ASA), ... of America (SSSA) Nov. 4-8, 2007 at the Ernest N. ...
Cached Biology News: 'Twinkle after-effect' can help retinal patients detect vision loss quickly and cheaply 2 'Twinkle after-effect' can help retinal patients detect vision loss quickly and cheaply 3Obesity-related hormone is higher in children with Down syndrome 2Food and environmental sustainability focus of ASA-CSSA-SSSA Annual Meetings 2
...
RABBIT ANTI PORCINE CARBOXYPEPTIDASE B...
LabFax: Immunochemistry...
... Maker, 1. Modular system for large ... up to six lab-cast or precast ... with 18- or 24-cm Immobiline DryStrip ... gel cassettes.Innovative design simplifies loading and ...
Biology Products: