Navigation Links
AEterna Zentaris Partner, Keryx, Reports Updated Phase 1/2 Data, Including New Survival Data, on Perifosine (KRX-0401) in the Treatment of Advanced Multiple Myeloma at the 51st Annual Meeting of the American Society of Hematology
Date:12/7/2009

Response Rate Increases to 41% and Median Overall Survival Reported at 25

Months for All Evaluable Patients

QUEBEC CITY, Dec. 7 /PRNewswire-FirstCall/ - AEterna Zentaris Inc. (NASDAQ: AEZS; TSX: AEZ) (the "Company"), a global biopharmaceutical company focused on endocrine therapy and oncology, today announced that its partner Keryx Biopharmaceuticals Inc. ("Keryx") ( KERX) reported updated efficacy and safety data as well as new survival data on the clinical activity of perifosine (KRX-0401) in combination with bortezomib (Velcade(R)) (+/- dexamethasone) in patients with relapsed/refractory multiple myeloma. Data from the study entitled "A Multicenter Phase 1/2 Study Evaluating the Safety and Efficacy of Perifosine (KRX-0401) + Bortezomib (Velcade(R)) in Patients with Relapsed or Relapsed / Refractory Multiple Myeloma Who Were Previously Treated with Bortezomib," was presented on Saturday, December 5th at the 51st annual meeting of the American Society of Hematology, in a poster presentation by Dr. Paul Richardson, Clinical Director of the Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute. Keryx is AEterna Zentaris' partner and licensee for perifosine in the United States, Canada and Mexico. Perifosine is also out-licensed to Handok in South Korea while AEterna Zentaris retains rights for the rest of the world.

Trial Results

Eighty-four patients with relapsed/refractory multiple myeloma were enrolled in a combined Phase 1/2 study (18 patients in the Phase 1 component and 66 patients in the Phase 2 component). The patients enrolled were heavily pre-treated with a median of 5 prior lines of therapy (range 1 - 13), including:

    - 100% of patients had been treated with bortezomib (55% of the patients
      were previously treated with at least two bortezomib-based therap
'/>"/>
SOURCE AETERNA ZENTARIS INC.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related biology technology :

1. AEterna Zentaris completes management team with the appointment of Chief Medical Officer
2. AEterna Zentaris to Present at Upcoming UBS Global Life Sciences Conference in New York
3. AEterna Zentaris Announces Outcome of Managements Strategic Review
4. AEterna Zentaris to Further Develop Three Follow-up Multi-targeted Cytotoxic Candidates to AEZS-112 as Potential Novel Cancer Treatment
5. AEterna Zentaris Reports First Patients Treated with Anti-Cancer Compound AEZS-108 in Phase 2 Trial in Ovarian and Endometrial Cancers
6. AEterna Zentaris to Present at the Upcoming Roth Capital Partners 20th Annual OC Growth Stock Conference in Dana Point, California
7. Aeterna Zentaris to Announce Fourth Quarter and Full-Year 2007 Financial and Operating Results on March 5, 2008
8. AEterna Zentaris Announces the Departure of SVP, Administrative and Legal Affairs
9. AEterna Zentaris and Paladin Labs Announce Sale and Purchase of Miltefosine Rights
10. Aeterna Zentaris Reports Fourth Quarter and Full-Year 2007 Financial and Operating Results
11. Aeterna Zentaris Begins Second Phase 3 Trial of Cetrorelix for Benign Prostatic Hyperplasia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2015)... , April 24 , 2015 PAREXEL ... biopharmaceutical services provider, today announced that Partnerships in Clinical ... Product Management, the 2015 Clinical Innovator of the Year.  ... development team for the Company,s Perceptive MyTrials ® ... award Thursday night during the 2015 Partnership Awards in ...
(Date:4/23/2015)... April 23, 2015 Athena San Diego, ... of executive women in San Diego’s technology and life ... Annual Pinnacle Awards at their Gala on April 30, ... Register now at http://athenasd.org/events/ , The Pinnacle ... Athena San Diego vision of fostering networking, risk taking ...
(Date:4/23/2015)... ORLANDO, Fla. , April 23, 2015 ... . releases his book "Age Healthier Live Happier - ... kick off the Age Management Medicine Group Conference at ... - 26, 2015. ",Age Healthier Live Happier, ... looking to avoid over-medication and searching for a higher ...
(Date:4/23/2015)... , April 23, 2015 WuXi PharmaTech (Cayman) ... capability and technology platform company serving the pharmaceutical, biotechnology ... China and the United States ... results for the first quarter of 2015 after the ... 2015 (which will be Thursday morning, May 14, 2015 ...
Breaking Biology Technology:PAREXEL Honored With 2015 Clinical Innovator Of The Year Award From Partnerships In Clinical Trials 2PAREXEL Honored With 2015 Clinical Innovator Of The Year Award From Partnerships In Clinical Trials 3PAREXEL Honored With 2015 Clinical Innovator Of The Year Award From Partnerships In Clinical Trials 4PAREXEL Honored With 2015 Clinical Innovator Of The Year Award From Partnerships In Clinical Trials 5Athena Pinnacle Awards to Honor Executives, Corporations and Educators Working to Promote Women Leaders 2Release and Book Signing of BioTE Medical President Gary Donovitz M.D. 'Age Healthier Live Happier' at Age Management Medicine Group (AMMG) Conference 2Release and Book Signing of BioTE Medical President Gary Donovitz M.D. 'Age Healthier Live Happier' at Age Management Medicine Group (AMMG) Conference 3WuXi PharmaTech Schedules First-Quarter 2015 Earnings Release 2WuXi PharmaTech Schedules First-Quarter 2015 Earnings Release 3
... Tom Koulopoulos said at the Fusion2006 CEO-CIO Symposium ... do that does not support their core competency and push ... discussion of outsourcing versus doing work in house raises a ... Group founder to tap his experience in IT and outsourcing. ...
... Wis. Berbee Information Networks Corporation ... U.S. IP communications partner of the year for ... customer satisfaction related to Berbee's sales and support ... of Berbee's Cisco practice, said it's the firm's ...
... the legacy of the 2005-2006 session of the Wisconsin Legislature ... court, where a few former leaders were prosecuted for illegally ... will be remembered for debating a steady diet of social ... trying to bring back the death penalty. , ,There's ...
Cached Biology Technology:IT outsourcing according to Tom Koulopoulos, part 1 2IT outsourcing according to Tom Koulopoulos, part 1 3Four ways lawmakers could help Wisconsins high-growth economy 2Four ways lawmakers could help Wisconsins high-growth economy 3
(Date:4/20/2015)... April 20, 2015 The announcement ... Glenbeigh Records Management (GRM), Ireland,s ... Islamic Bank. Having built up an impressive track record of ... leading player within the records management sector in ... double is GCC staffbase and employ a further eight staff ...
(Date:4/13/2015)... , April 13, 2015 ... Research, "Global Biometrics Market Forecast & Opportunities, 2020", the ... CAGR of around 14% till 2020. The biometrics ... large scale implementation and review of biometric management ... of new products with greater efficiency, are resulting ...
(Date:4/8/2015)... April 8, 2015  Infinisource, a leading provider ... and Morpho, a leading supplier of biometric identification ... the market,s most advanced biometrically-enabled time clock, the ... time clock is setting a bold, new standard ... for the small and mid-size employer. When connected ...
Breaking Biology News(10 mins):Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 2Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 3Global Biometrics Market to Cross US$ 21 Billion by 2020: TechSci Research 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 3
... COLUMBIA, Mo. For 5,000 years, the Chinese have ... balance of positive and negative energies in the body. In ... the measures used to classify the overall physical status of ... developed computer software that combines the ancient practices and modern ...
... PARIS, May 25, 2012 Babolat, international ... interactive racquet, "Babolat Play & Connect," at the French ... innovation with nearly infinite potential. Welcome to the tennis ... of the first interactive racquet with organized demonstrations featuring ...
... Cold Spring Harbor, N.Y. In a study published ... Cold Spring Harbor Laboratory (CSHL) scientists describe the three-dimensional ... piece of RNA that "guides" the protein,s ability to ... in RNA interference (RNAi), a powerful cellular phenomenon that ...
Cached Biology News:Tongue analysis software uses ancient Chinese medicine to warn of disease 2"Babolat Play & Connect" - Worldwide Exclusive Event at the French Open 2"Babolat Play & Connect" - Worldwide Exclusive Event at the French Open 3"Babolat Play & Connect" - Worldwide Exclusive Event at the French Open 4CSHL researchers solve structure of human protein critical for silencing genes 2CSHL researchers solve structure of human protein critical for silencing genes 3
... The Label IT siRNA Tracker Intracellular ... to directly label and deliver siRNA, of ... manner, for in vitro tracking experiments. Subcellular ... expression can be monitored following introduction of ...
... Label IT siRNA Tracker Intracellular Localization ... a straight forward approach to directly ... design, in an efficient yet non-destructive ... Subcellular localization and functional inhibition of ...
Ideal for chemical processing that requires downward flow of exhaust fumes. Powderful 1200 CFM blower draws fumes into sub-surface bonded charcoal filter for safe removal of organic vapors (final HEP...
... The mir Vana miRNA Bioarray Essentials ... for hybridization and post-hybridization washing of the ... preparation that has been labeled using Ambions ... includes a positive control miRNA (Bioarray ID BA10001) ...
Biology Products: