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AEterna Zentaris Announces Results from its European Phase 3 Study with Cetrorelix in Benign Prostatic Hyperplasia
Date:12/7/2009

-week screening period to confirm severity and stability of voiding symptoms based on the IPSS. Patients were then randomly allocated in a double-blind fashion to one of two cetrorelix dose groups or placebo, in a 2:1:1 ratio. Patients were administered cetrorelix by intra-muscular (IM) injection at Week 0, 2, 26 and 28 (for treatment Arm A, those in Arm B received IM injection at week 0, 2 and placebo injections both at Week 26 and 28). Patients in treatment Arm C received placebo injections at Week 0, 2, 26 and 28. All patients were followed up to Week 52. The study included 420 patients overall, 212, 106, and 102 patients allocated to Arm A, B, and C, respectively.

Conference Call

The Company will host a conference call and webcast to discuss these results later today, Monday, December 7, 2009 at 4:30 p.m., Eastern Time.

Participants may access the live webcast via the Company's website at www.aezsinc.com in the "Investors" section, or by telephone using the following numbers: (outside Canada): 888-231-8191, (Canada): 514-807-9895 or 647-427-7450. A replay of the webcast will also be available on the Company's website for a period of 30 days.

About the Phase 3 Program with Cetrorelix in BPH

The Phase 3 trial program involving more than 1,600 patients with symptomatic BPH in Canada, the United States and Europe has been completed. In addition to the efficacy trial Z-036, the program included a placebo-controlled safety and efficacy trial Z-033, the single-armed safety study Z-041, and the Thorough QT study Z-043. Results for all of these trials were disclosed recently.

About Cetrorelix

Cetrorelix pamoate is a compound that was being investigated for the treatment of BPH. Cetrorelix is part of AEterna Zentaris' luteinizing hormone-releasing hormone (LHRH) antagonist therapeutic approach.

About AEterna Zentaris Inc.


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SOURCE AETERNA ZENTARIS INC.
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10. Aeterna Zentaris Reports Fourth Quarter and Full-Year 2007 Financial and Operating Results
11. Aeterna Zentaris Begins Second Phase 3 Trial of Cetrorelix for Benign Prostatic Hyperplasia
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