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AEterna Zentaris Announces Outcome of Management's Strategic Review
Date:10/2/2007

t priority, being

the asset with the largest combination of probability of success,

proximity to launch and potential medical and commercial value. The

Company has decided to seek a commercialization partner for

cetrorelix, which, in this indication, has potential for base case

peak annual sales of over $500 million in the United States market

alone. After defining the critical path to registration, the Company

expects to launch cetrorelix in the BPH indication in 2011.

Furthermore, after optimization of formulation and trial design, the

company plans to move into Phase 2b in the endometriosis indication

and will announce timelines relative to this program in the near

future. As was announced in May 2007, the rights to cetrorelix in the

endometriosis indication were regained from Solvay. The decision to

proceed with development was made based on:

a) the proven safety and efficacy of Cetrotide(R)

b) the overall database from preclinical and clinical studies in

endometriosis

c) the large unmet medical needs and commercial opportunity in the

area of endometriosis.

Additionally, as with the BPH indication, AEterna Zentaris will

eventually seek a commercialization partner as cetrorelix has the

potential for base case peak annual sales of approximately

$200 million in the U.S. market alone in the endometriosis

indication.

AEZS-108

AEterna Zentaris has established its cytotoxic conjugate, AEZS-108,

as its highest earlier-stage priority, and will therefore initiate a

Phase 2 trial with this compound in a both endometrial and ovarian

cancers before year end. The Company feels AEZS-108 has large market

opportunities that could compare to those for doxorubicin.

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SOURCE AETERNA ZENTARIS INC.
Copyright©2007 PR Newswire.
All rights reserved

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