Navigation Links
AEterna Zentaris: New Data Published on its Ghrelin Antagonist Compound, AEZS-123 (JMV2959), Supports its Use in Alcohol Addiction
Date:7/7/2009

ion said, "Ghrelin's action in the brain may be of importance for several addictions, including chemical drugs such as alcohol and even food."

Daniel Perrissoud, Senior Director of Project Management at AEterna Zentaris and one of the authors of the paper stated, "The discovery of the Gothenburg team that the reward system is a target of ghrelin effects, opens new development opportunities for our proprietary ghrelin receptor antagonists. In the field of addiction, the clinical proof of efficacy can be obtained in a more time- and cost-effective manner than in the field of obesity, as short-term clinical laboratory paradigms can be used for the clinical evaluation."

The article entitled, "Requirement of Central Ghrelin Signaling for Alcohol Reward" appears today in the July 7, 2009 issue of Proceedings of the National Academy of Sciences (PNAS 2009; 106:11318-11323) and was published on line on June 29, 2009 in the early edition of the journal.

About AEterna Zentaris' Ghrelin Antagonist Program

Ghrelin is a natural peptide hormone produced by the stomach that increases appetite and induces accumulation of fat tissue. The discovery of ghrelin and its receptors opens up new opportunities for the treatment of obesity and eating disorders through the use of ghrelin antagonists to suppress appetite and fat deposition.

In 2004, AEterna Zentaris signed two agreements for the development of ghrelin antagonists with the Institut des biomolecules Max Mousseron of the University of Montpellier, France, directed by Prof. Jean Martinez, and with the Department of Experimental and Environmental Medicine of the University of Milan, Italy, directed by Prof. Vittorio Locatelli. The research projects were targeting the chemical synthesis and pharmacological investigation of new compounds acting as ghrelin antagonists.

In 2006, AEterna Zentaris reported first in vivo pharmacological data on the capability of proprietary
'/>"/>

SOURCE AETERNA ZENTARIS INC.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related biology technology :

1. AEterna Zentaris completes management team with the appointment of Chief Medical Officer
2. AEterna Zentaris to Present at Upcoming UBS Global Life Sciences Conference in New York
3. AEterna Zentaris Announces Outcome of Managements Strategic Review
4. AEterna Zentaris to Further Develop Three Follow-up Multi-targeted Cytotoxic Candidates to AEZS-112 as Potential Novel Cancer Treatment
5. AEterna Zentaris Reports First Patients Treated with Anti-Cancer Compound AEZS-108 in Phase 2 Trial in Ovarian and Endometrial Cancers
6. AEterna Zentaris to Present at the Upcoming Roth Capital Partners 20th Annual OC Growth Stock Conference in Dana Point, California
7. Aeterna Zentaris to Announce Fourth Quarter and Full-Year 2007 Financial and Operating Results on March 5, 2008
8. AEterna Zentaris Announces the Departure of SVP, Administrative and Legal Affairs
9. AEterna Zentaris and Paladin Labs Announce Sale and Purchase of Miltefosine Rights
10. Aeterna Zentaris Reports Fourth Quarter and Full-Year 2007 Financial and Operating Results
11. Aeterna Zentaris Begins Second Phase 3 Trial of Cetrorelix for Benign Prostatic Hyperplasia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... (PRWEB) August 28, 2014 PrimeSource ... construction materials, selected SoundConnect to support ... cloud based audio and web conferencing platform GlobalMeet ... support PrimeSource’s employees’ needs. SoundConnect delivers award ... , PrimeSource Building Products will be utilizing ...
(Date:8/28/2014)... New York, NY (PRWEB) August 28, 2014 ... has renewed its long term partnership with PTI ... to provide clients with state of the art leak ... state of the art instruments currently available. As part ... a new High Voltage Leak Detection Instrument ...
(Date:8/27/2014)... (PRWEB) August 27, 2014 Green & ... in Series B funding and secured Otter Capital as ... capital will accelerate commercialization of GGI’s Agriplier™ technology, building ... types. , “Since our first meeting, we have ... the biological product space,” said Alan Sobba, President and ...
(Date:8/27/2014)... California (PRWEB) August 27, 2014 ... (LLNL), through Lawrence Livermore National Security LLC ... to develop and deliver a state-of-the-art laser system ... facility (ELI Beamlines), under construction in the Czech ... performance, the laser system, called the " High ...
Breaking Biology Technology:PrimeSource Chooses SoundConnect as Collaboration Provider 2Whitehouse Labs Renews Partnership with PTI Inspection Systems 2Whitehouse Labs Renews Partnership with PTI Inspection Systems 3Green & Grow Inc. Secures $6M Series B Funding from Otter Capital 2Green & Grow Inc. Secures $6M Series B Funding from Otter Capital 3LLNL Synchs up with ELI Beamlines on Timing System 2LLNL Synchs up with ELI Beamlines on Timing System 3
... The Appignani Bioethics Center, a project of the American ... National Press Club to examine controversial emerging technologies in ... by Jonathan Moreno and Andrew Light, both of the ... ethical and political angles. , A video of ...
... Realty Trust, Inc. (NYSE: BMR ) announced today that the ... on its unsecured line of credit by $65 million to an ... of the facility. The weighted-average effective interest rate of the ... The maturity date remains August 1, 2011, which may be extended ...
... SAN DIEGO, Nov. 9 NexBio, Inc. announced the ... College of Allergy, Asthma, and Immunology in Miami, Florida. ... Decreases Airway Resistance and Has Potent Anti-inflammatory Effects in ... is an investigational broad spectrum host-targeting drug candidate being ...
Cached Biology Technology:Jonathan Moreno and Andrew Light Speak About Biotechnology and Global Warming at the National Press Club 2Jonathan Moreno and Andrew Light Speak About Biotechnology and Global Warming at the National Press Club 3BioMed Realty Trust Receives Commitments to Expand Unsecured Line of Credit to $665 Million 2BioMed Realty Trust Receives Commitments to Expand Unsecured Line of Credit to $665 Million 3NexBio(R) Presents Data Showing Anti-Asthma Activity of DAS181 (Fludase(R)*) at ACAAI 2009 2NexBio(R) Presents Data Showing Anti-Asthma Activity of DAS181 (Fludase(R)*) at ACAAI 2009 3
(Date:8/29/2014)... and number of connections in transcription factor networks (TFNs) ... a study published in PLOS Computational Biology ... signature contributes to a network,s resilience against mutations. ... assortativity of TFN models has a greater effect on ... of assortativity," said Dov A. Pechenick, PhD, lead author ...
(Date:8/29/2014)... stretch them, twist them, fold them: modern materials that ... potential, whether as artificial skin or electronic paper. , ... a challenge but a new way of working with ... a game-changer. , Previous success in the field ... use of precious gold and silver nanowires. , ...
(Date:8/28/2014)... that an expansion of marine protected areas is needed ... According to investigators from the Wildlife Conservation Society ... focused on saving the largest numbers of species, often ... and difficult-to-replace ecological functions. , Many vital ... species that also are food for millions of people. ...
Breaking Biology News(10 mins):Assortativity signatures of transcription factor networks contribute to robustness 2Copper shines as flexible conductor 2Study finds marine protected areas inadequate for protecting fish and ocean ecology 2
... Exposure to light and possibly photosynthesis itself could be helping ... impervious to washing, according to research published in the October ... Salmonella enterica is a common cause of ... million human cases per year in the United States. ...
... emissions trading has put a price on something that used ... , Allocating free allowances creates problematic expectations among companies; "If ... number of emission allowances tomorrow." This runs completely counter to ... Wrke, at the University of Gothenburg, Sweden. Markus Wrke ...
... Physical Laboratory (NPL), the UK,s National Measurement Institute, is ... of organic electronics. The market for organic, or plastic, ... 2015 (IDTechEx), and NPL is seeking to ensure the ... commercial success in this emerging area. The technology ...
Cached Biology News:Light, photosynthesis help bacteria invade fresh produce 2The EU must allocate fewer emission allowances and stop making free allocations 2The EU must allocate fewer emission allowances and stop making free allocations 3NPL supports growing organic electronics industry 2
... the Moticam 2300 camera (MC2300) attaches to ... or trinocular port. Included in the standard ... 2.0ML software offers quick and accurate image ... resolution for examination or documentation purposes. The ...
5X StabilCoat Immunoassay Stabilizer is a 5X concentrate solution of StabilCoat Immunoassay Stabilizer. The shelf-life of 5X StabilCoat Immunoassay Stabilizer is 2 years when stored at 4C. Product ...
... Stabilizer is a bovine protein-free alternative ... is an aqueous solution that contains ... buffer (3-(N-Morpholino) propanesulfonic acid), pH 6.0 ... of 0.02% methylisothiazolone and 0.02% bromonitrodioxane ...
...
Biology Products: