Navigation Links
AEterna Zentaris: Article on Phase 2 Trial with Cetrorelix in BPH to be Published in European Urology Journal
Date:5/13/2008

er Phase 3 efficacy study, being led by Prof. Frans M.J. Debruyne, M.D., Ph.D., from The Netherlands, will enroll approximately 400 patients in Europe. The third Phase 3 trial currently screening patients, is an open-label, single-armed multi-center safety study involving approximately 500 patients in both North America and Europe, and is being led by Joel Kaufman, M.D., Associate Clinical Professor of Urology, University of Colorado School of Medicine, Denver, Colorado, and Urology Research Options, Aurora, Colorado.

The primary endpoint for both North American and European efficacy studies is the change in I-PSS between baseline and Week 52. Other efficacy endpoints include additional measures of BPH-symptom progression and the need for BPH-related surgery. Safety endpoints include changes in sexual function. Other important endpoints include plasma changes in levels of testosterone, and assessment of other adverse events.

The cetrorelix Phase 3 program is based on comprehensive clinical practice guidelines to ensure quality control, including input from expert advisors on study design, publishing results in peer-reviewed journals and discussion of the studies with regulatory agencies.

Benign Prostatic Hyperplasia

Benign prostatic hyperplasia (BPH) is one of the most common diseases of aging men - affecting more than 20 million men in the United States - but its etiology is far from being completely understood. Data from ongoing research suggest BPH and its associated lower urinary tract symptoms (LUTS) are more complex conditions than once thought. While previous research on BPH etiology tended to focus on testosterone and other hormones, more recent research suggests other factors may play a greater role in the development of BPH and LUTS - including inflammation, various growth factors, and adrenoreceptors.

BPH-associated LUTS include frequent urination and/or urgent need to urinate, waking at night to urinate (nocturia), diff
'/>"/>

SOURCE AETERNA ZENTARIS INC.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related biology technology :

1. AEterna Zentaris completes management team with the appointment of Chief Medical Officer
2. AEterna Zentaris to Present at Upcoming UBS Global Life Sciences Conference in New York
3. AEterna Zentaris Announces Outcome of Managements Strategic Review
4. AEterna Zentaris to Further Develop Three Follow-up Multi-targeted Cytotoxic Candidates to AEZS-112 as Potential Novel Cancer Treatment
5. AEterna Zentaris Reports First Patients Treated with Anti-Cancer Compound AEZS-108 in Phase 2 Trial in Ovarian and Endometrial Cancers
6. AEterna Zentaris to Present at the Upcoming Roth Capital Partners 20th Annual OC Growth Stock Conference in Dana Point, California
7. Aeterna Zentaris to Announce Fourth Quarter and Full-Year 2007 Financial and Operating Results on March 5, 2008
8. AEterna Zentaris Announces the Departure of SVP, Administrative and Legal Affairs
9. AEterna Zentaris and Paladin Labs Announce Sale and Purchase of Miltefosine Rights
10. Aeterna Zentaris Reports Fourth Quarter and Full-Year 2007 Financial and Operating Results
11. Aeterna Zentaris Begins Second Phase 3 Trial of Cetrorelix for Benign Prostatic Hyperplasia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... 18, 2014 Scientists at NYU Langone Medical Center ... efficiency of the process for turning adult cells into ... including vitamin C. Using the new technique in mice, ... from adult skin cells by more than 20-fold compared ... efficient and reliable, and thus should generally accelerate research ...
(Date:9/19/2014)...  Nektar Therapeutics (NASDAQ: NKTR ) ... analgesic profiles of a series of the company,s ... The preclinical research candidates were created using Nektar,s ... The analgesic properties of kappa receptor agonism are ... Kappa opioid receptors are expressed in the peripheral ...
(Date:9/19/2014)... 19, 2014 ... ) has announced the addition of the  "Micro ... to their offering.       (Logo: http://photos.prnewswire.com/prnh/20130307/600769) ... of the fastest-growing segments in the chromatography market. ... 2013, and expected to reach $2.0 billion by ...
(Date:9/18/2014)... About POCT POCT, ... clinical laboratory. It helps in making fast clinical ... medication. POCT is gaining popularity due to the ... as diabetes, heart disease, and obesity. It is ... to minimize errors during the diagnosis of patients. ...
Breaking Biology Technology:NYU Langone scientists report reliable and highly efficient method for making stem cells 2NYU Langone scientists report reliable and highly efficient method for making stem cells 3Nektar Presents Positive Preclinical Data on Oral, Peripherally-Acting Kappa Agonist Molecules at 2014 American Academy of Pain Management Meeting 2Nektar Presents Positive Preclinical Data on Oral, Peripherally-Acting Kappa Agonist Molecules at 2014 American Academy of Pain Management Meeting 3Nektar Presents Positive Preclinical Data on Oral, Peripherally-Acting Kappa Agonist Molecules at 2014 American Academy of Pain Management Meeting 4Nektar Presents Positive Preclinical Data on Oral, Peripherally-Acting Kappa Agonist Molecules at 2014 American Academy of Pain Management Meeting 5Micro Market Monitor : Global Pre-packed Chromatography Columns 2POCT Market in China 2014-2018 2
... Insmed Incorporated (Nasdaq CM: INSM), a biopharmaceutical company, announced ... will be presenting a corporate overview at the 2011 ... August 16, 2011, at 8:00 AM ET, in New ... available on the Investors page of Insmed,s website, ...
... and BERGEN, Norway, August 11, 2011 Valkee ... and scientists from the University of Oulu will present new ... Annual Meeting 2011, August 12-14. Their research localized ... - in all of the 18 evaluated areas of the ...
... 10, 2011 Exagen Diagnostics, Inc. , a ... markets proprietary tests for rheumatologists and gastroenterologists, announced today ... Operating Officer. Tornoe has more than 20 ... and marketing, making him a key hire as Exagen ...
Cached Biology Technology:Insmed to Present at 2011 Wedbush Securities Life Sciences Management Access Conference 2The Human Brain is Sensitive to Light, Breakthrough Findings From Valkee and the University of Oulu 2The Human Brain is Sensitive to Light, Breakthrough Findings From Valkee and the University of Oulu 3Eric Tornoe Joins Exagen Diagnostics as President and COO 2
(Date:9/18/2014)... colleagues have built the first smartphone app that ... behavioral trends. In other words, your smartphone knows ... don,t -- and how that affects you. , ... depression and loneliness to their academic performance, also ... for example, to monitor mental health, trigger intervention ...
(Date:9/18/2014)... so you might expect that most would have an ... dogs are distinctly more pessimistic than others, research from ... is exciting because it measures positive and negative emotional ... and dog owners an insight into the outlook of ... from the Faculty of Veterinary Science. Her PhD research ...
(Date:9/18/2014)... The global cycles of carbon and nitrogen comprise ... human and environmental systems have caused imbalances and ... greenhouse gases (GHGs). Increased GHGs result in climate ... terrestrial ecosystems, oceans and the atmosphere. Understanding these ... exciting branch of environmental science during the past ...
Breaking Biology News(10 mins):New Dartmouth smartphone app reveals users' mental health, performance, behavior 2New Dartmouth smartphone app reveals users' mental health, performance, behavior 3New Dartmouth smartphone app reveals users' mental health, performance, behavior 4Dogs can be pessimists too 2Dogs can be pessimists too 3Greenhouse gas research enters a new era 2
... cellsas indicated by a molecular imaging techniquecould tell researchers ... headaches and psychosis in schizophrenic patients, occur and provide ... two studies published in the November issue of the ... positron emission tomography (PET)a noninvasive molecular imaging techniqueresearchers were ...
... When 100 m sprinters launches themselves from the starting blocks, ... few strides. Acceleration through the first few strides is the ... by an American football star, who sprints in his position ... his technique and training regime, Piazza decided to focus on ...
... have confirmed that the largest bat in Europe, ... the Late Pleistocene (between 120,000 and 10,000 years ago). ... at Abrc Roman (Barcelona) prove that this bat had ... than it does today, having declined due to the ...
Cached Biology News:Unlocking mysteries of the brain with PET 2Short heels make elite sprinters super speedy 2The largest bat in Europe inhabited northeastern Spain more than 10,000 years ago 2
... kit for stabilizing 400g of purified RNA ... for the stabilization of aqueous RNA samples ... such as guanidine, phenol/chloroform, silica, oligo dT ... Kits contain all the necessary components for ...
...
... wide mouth PYREX Fernbach-style culture flasks have ... the flask bottom to achieve maximal oxygen ... flasks have a Delong-style 38mm neck for ... For plastic closures see Nos. CLS2679638 or ...
... Fernbach-style culture flask is designed for culturing organisms ... It can also be used in serum production. ... achieve maximal oxygen transfer to culture medium. Beaded ... cotton plugs or No. 13 rubber stoppers. This ...
Biology Products: