Navigation Links
AEterna Zentaris: Article on Phase 2 Trial with Cetrorelix in BPH to be Published in European Urology Journal
Date:5/13/2008

ily dosing suggested the use of the luteinizing hormone-releasing hormone antagonist cetrorelix for the treatment of symptoms from BPH. The objective was to assess efficacy and safety of three dosing schemes of cetrorelix in patients with symptomatic BPH.

Trial Design

After a run-in period with four weekly injections of placebo, 140 patients with an international prostate symptoms score (I-PSS) >= 13 and a peak urinary flow rate (PFR) 5-13 ml/s were randomly allocated to four treatment groups. Patients received either cetrorelix at dosages of 5 mg/wk x 4, 10 mg/wk x 2 or 10 mg/wk x 4 or placebo.

Main and secondary endpoints included I-PSS, PFR and mean uroflow, residual urinary volume, prostate volume, plasma testosterone, quality of life, and sexual function which were evaluated over a total of 20 weeks after randomization.

Results

In all cetrorelix groups, a rapid improvement in mean I-PSS was obtained, with a peak effect of -5.4 to -5.9 (placebo: -2.8). After all dosages of cetrorelix given, changes from baseline and differences to placebo were statistically significant up to week 20. Similarly, secondary parameters showed a significant, rapid, and persistent improvement for all cetrorelix dosages. All dosage regimens were well tolerated. The study evaluated a single treatment course only; further studies with repeated treatment courses will be required to establish a dose regimen for long-term disease management.

Conclusions

In summary, the trial showed a rapid onset in improvement of I-PSS, urinary symptoms and quality of life, accompanied by a slight reduction in prostate size with a short course therapy with cetrorelix. The improvement lasted well beyond the dosing period. This should, therefore, allow for the development of intermittent dosage regimens of cetrorelix with two or three treatment courses per year, thus relieving concerns about treatment compliance with drugs requiring daily dosing.

About C
'/>"/>

SOURCE AETERNA ZENTARIS INC.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related biology technology :

1. AEterna Zentaris completes management team with the appointment of Chief Medical Officer
2. AEterna Zentaris to Present at Upcoming UBS Global Life Sciences Conference in New York
3. AEterna Zentaris Announces Outcome of Managements Strategic Review
4. AEterna Zentaris to Further Develop Three Follow-up Multi-targeted Cytotoxic Candidates to AEZS-112 as Potential Novel Cancer Treatment
5. AEterna Zentaris Reports First Patients Treated with Anti-Cancer Compound AEZS-108 in Phase 2 Trial in Ovarian and Endometrial Cancers
6. AEterna Zentaris to Present at the Upcoming Roth Capital Partners 20th Annual OC Growth Stock Conference in Dana Point, California
7. Aeterna Zentaris to Announce Fourth Quarter and Full-Year 2007 Financial and Operating Results on March 5, 2008
8. AEterna Zentaris Announces the Departure of SVP, Administrative and Legal Affairs
9. AEterna Zentaris and Paladin Labs Announce Sale and Purchase of Miltefosine Rights
10. Aeterna Zentaris Reports Fourth Quarter and Full-Year 2007 Financial and Operating Results
11. Aeterna Zentaris Begins Second Phase 3 Trial of Cetrorelix for Benign Prostatic Hyperplasia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/24/2014)... Boston, MA (PRWEB) December 23, 2014 ... presentation, Dr. James L. Sherley, director of the Adult ... attention on an often overlooked and under appreciated unique ... “Asymmetric Self-Renewal by Distributed Stem Cells: Misunderstood in the ... his message to congress participants. He gave the ...
(Date:12/24/2014)... 23, 2014 Nashville Fertility Center announced ... treasurer for the American Society for Reproductive Medicine (ASRM), ... research in reproductive medicine. In his new role ... the executive board and will have a voice in ... has actively supported ASRM since 1984 when he joined ...
(Date:12/24/2014)... -- PharmaBoardroom,s new report, , Healthcare ... for free download , digs deep into this vibrant ... the sector today. One area where ... developing a homegrown pharmaceutical manufacturing base, even if the government,s ... way off. A cursory comparison with neighboring Morocco ...
(Date:12/22/2014)... Dec. 22, 2014   Synthetic Biologics, ... of pathogen-specific therapies for serious infections and ... microbiome, today announced positive topline safety and ... trial of SYN-004, the Company,s investigational oral ... Clostridium difficile (C. difficile) infection, antibiotic-associated ...
Breaking Biology Technology:Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 2Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 3Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 4Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 2Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 3PharmaBoardroom Releases New Algeria Pharmaceuticals Report 2PharmaBoardroom Releases New Algeria Pharmaceuticals Report 3Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 2Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 3Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 4Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 5
... PharmaVentures announced today that it was delighted ... US and Canada as Merck & Co) to secure its ... Nottingham and Roslin BioCentre, for the former MSD research facility ... working between MSD, the Scottish Life Sciences community and the ...
... 17, 2012  Cepheid (Nasdaq: CPHD ) today ... the position of Senior Vice President, Human Resources, effective ... Cepheid from Verigy, Inc., a wholly owned subsidiary of ... Vice President of Human Resources.  Prior to Verigy, Mr. ...
... from a Nobel Laureate. Find out how major discoveries ... policy, education, and research in other countries. The iBioSeminars ... online, on-demand, and for free. iBioSeminars ... biology seminars given by the world,s leading researchers. The ...
Cached Biology Technology:PharmaVentures Helps Secure Investor for Former MSD Research Site 2Cepheid Welcomes Senior Vice President of Human Resources 2iBioSeminars and iBioMagazine: Free, Online Biology Seminars and Short Talks by Leading Scientists 2
(Date:12/11/2014)... , Dec. 10, 2014  Data Sciences International ... has released a new series of digital telemetry ... toxicology researchers. M series, part of the PhysioTel™ ... the best possible physiologic data when incorporating functional ... functional endpoints to toxicology studies has evolved from ...
(Date:12/10/2014)... 9, 2014  Valencell, a leader in performance biometric ... staggering demand from its licensees for highly accurate, clinically ... not solely coming from fitness and health sectors, but ... "A wearable is only as useful as the biometric ... ultimate driver in long-term mass consumer adoption of wearable ...
(Date:12/10/2014)... -- CIE San Diego has launched an innovative trust ... that enhances care coordination among social service and care ... earned a second $1 million grant from the Alliance ... in community and; will be recognized as a "Live ... 4-6p. CIE San Diego today announced the ...
Breaking Biology News(10 mins):New telemetry implants expected to change how large animal toxicology studies are conducted 2Wearable Technology Products Demand Highly Accurate Biometric Technology 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 3Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 4
... acne live on everyone,s skin, yet one in five people ... a lifetime. In a boon for teenagers everywhere, a ... Louis and the Los Angeles Biomedical Research Institute has discovered ... "good" strains that may protect the skin. ...
... in German . , On the way ... Karlsruher Institut fr Technologie, or KIT for short, in cooperation ... realized another important milestone: the second process stage of the ... entrained flow gasifier bioliq II was handed over for operation. ...
... make up ScienceWorksForU.S. today again called on Congress to ... spending that will result in drastic reductions in funding ... U.S. economy of reduced R&D under sequestration are significant ... over the next nine years and 200,000 fewer jobs ...
Cached Biology News:New study could explain why some people get zits and others don't 2New study could explain why some people get zits and others don't 3Bioliq pilot plant: Successful operation of high-pressure entrained flow gasification 2Bioliq pilot plant: Successful operation of high-pressure entrained flow gasification 3Sequester will have a devastating impact on america's research enterprise 2Sequester will have a devastating impact on america's research enterprise 3
... Microarrays designed for genome-wide microRNA ... flexible and powerful Paraflo microfluidic on-chip ... as part of our comprehensive microRNA ... Content The Mammals microRNA Microarray ...
... The LIBS-ELITE houses Ocean Optics LIBS2000+ ... Research Universal Platform (UP) Ablation Chamber to ... position control. The systems features include a ... and targeting functions, precise X-Y sample positioning, ...
...
... The Varian 500-MS LC Ion ... for high-throughput LC/MS analysis where sensitivity, ... Varian 500-MS provides a robust platform ... sensitivity, mass resolution, and mass stability ...
Biology Products: