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ACT Obtains Exclusive License for Hemangioblast Technology in North America
Date:7/21/2011

r of ACT.  "Hemangioblasts can be used to provide transfusable blood components, such as red blood cells and platelets, as well as cells capable of affecting vascular repair.  We hope that these programs will eventually help address the critical care shortage of blood for emergency situations. In addition, our preclinical research has shown the ability of hemangioblast-derived cells to repair vascular damage when administered systemically, offering potential therapeutic uses to treat vascular ischemic damage, ischemia-reperfusion injury, diabetic vascular disease and peripheral artery disease (PAD), which represent the leading causes of death and/or disability worldwide.  Indeed, in preclinical studies, these cells quickly repaired vascular damage, cutting the death rate after a heart attack in half and restoring the blood flow to ischemic limbs that might otherwise have required amputation."

The proprietary hemangioblast technology developed by SCRMI and ACT is uniquely well-suited for developing stem cell-based therapies because they are highly expandable and can consistently and reproducibly give rise to various cells of the hematopoietic (blood) and endothelial (vascular) lineages.  Strong clinical demand for donated platelets, for example, has stimulated interest in generating renewable sources of transfusable platelets.  In recent scientific publications, SCRMI scientists demonstrated that it is feasible to generate functional megakaryocytes and platelets from hESCs on a large scale.  The hESC-platelets displayed features that were indistinguishable from those of normal blood platelets, and participated in both clot formation and retraction in-vitro.

In September of last year, Dr. Lanza and Kwang-Soo Kim, Ph.D. (Harvard University/McLean Hospital and CHA Stem Cell Institute),

SOURCE Advanced Cell Technology, Inc.
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