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ACT Obtains Exclusive License for Hemangioblast Technology in North America

MARLBOROUGH, Mass., July 21, 2011 /PRNewswire/ -- Advanced Cell Technology, Inc. ("ACT"; OTCBB: ACTC), a leader in the field of regenerative medicine, announced today that it has entered into an agreement with CHA Bio & Diostech Co, Ltd. ("CHA Biotech"), a leading South Korea-based biotechnology company, designed to enhance the efforts of the two companies' international joint venture, Stem Cell & Regenerative Medicine International (SCRMI).  Under the terms of the agreement, SCRMI exclusively licenses the rights to its hemangioblast program to ACT for North America (United States and Canada) and to CHA Biotech for Korea and Japan.  Both companies will work to develop clinical therapies based on the joint venture's proprietary hemangioblast cell technology.  

Formed as a joint venture between ACT and CHA Biotech, SCRMI has been harnessing expertise from both sides of the globe in order to drive cutting-edge stem cell research endeavors.  Under the terms of the agreement, the SCRMI scientists involved in hemangioblast research have been reassigned to ACT where they will continue their research and product development efforts as ACT employees.  A total of 10 SCRMI employees are being reassigned to ACT, including Shi-Jiang (John) Lu, Ph.D., SCRMI's Senior Director of Research, Erin Kimbrel, Ph.D., Qiang (Allen) Feng, Ph.D., and their respective teams.  SCRMI's research has focused on differentiating human embryonic stem cells (hESCs) and induced pluripotent stem (iPS) cells into hemangioblasts - a multipotent cell that is a common precursor to blood, immune, and vascular tissue.  The ownership in SCMRI remains largely unchanged between ACT and CHA Biotech, with the joint venture ceasing internal research activity and transitioning to a licensing entity.

"The clinical prospects for this technology are immense," said Robert Lanza, M.D., chief scientific officer of ACT.  "Hemangioblasts can be used to provide transfusable blood components, such as red blood cells and platelets, as well as cells capable of affecting vascular repair.  We hope that these programs will eventually help address the critical care shortage of blood for emergency situations. In addition, our preclinical research has shown the ability of hemangioblast-derived cells to repair vascular damage when administered systemically, offering potential therapeutic uses to treat vascular ischemic damage, ischemia-reperfusion injury, diabetic vascular disease and peripheral artery disease (PAD), which represent the leading causes of death and/or disability worldwide.  Indeed, in preclinical studies, these cells quickly repaired vascular damage, cutting the death rate after a heart attack in half and restoring the blood flow to ischemic limbs that might otherwise have required amputation."

The proprietary hemangioblast technology developed by SCRMI and ACT is uniquely well-suited for developing stem cell-based therapies because they are highly expandable and can consistently and reproducibly give rise to various cells of the hematopoietic (blood) and endothelial (vascular) lineages.  Strong clinical demand for donated platelets, for example, has stimulated interest in generating renewable sources of transfusable platelets.  In recent scientific publications, SCRMI scientists demonstrated that it is feasible to generate functional megakaryocytes and platelets from hESCs on a large scale.  The hESC-platelets displayed features that were indistinguishable from those of normal blood platelets, and participated in both clot formation and retraction in-vitro.

In September of last year, Dr. Lanza and Kwang-Soo Kim, Ph.D. (Harvard University/McLean Hospital and CHA Stem Cell Institute), won a National Institutes of Health (NIH) Director's Opportunity Award for research in "Translating Basic Science Discoveries into New and Better Treatments" under the American Recovery & Reinvestment Act of 2009. The NIH Award provides McLean Hospital and SCRMI with $1.9 million to explore the potential of protein-induced pluripotent stem (iPS) cells as a source of universal red blood cells and platelets for transfusion.  Drs. Lanza and Kim will continue to serve as principle investigators on this grant.

"We are very excited about this next step in our joint venture," said Hyung-Min Chung, Ph.D., chief technology officer of CHA Biotech and chief executive officer of SCRMI. "While still permitting us to leverage the combined expertise of our two companies, this new licensing and development arrangement should help to accelerate the development of clinical programs, and open the door to further government-sponsored research than had been available to SCRMI.  Fundamentally, we believe that the hemangioblast program has great potential to address many unmet medical needs through the use of stem cell technology, and feel that this realignment in licensing and research efforts is an important step towards CHA Biotech and ACT realizing those goals."

"Given the progress that has been made by our teams in the development of hemangioblast-derived products, coupled with bringing the scientists from the joint venture into ACT and Dr. Lanza's devotion to these programs, this new exclusive license affords ACT a unique new pipeline of therapeutic products, some of which are not that far from the clinic," added Gary Rabin, interim chairman and chief executive officer of ACT. "The market opportunities around diabetes-related diseases alone are vast.  Diabetes is the leading cause of blindness, non-traumatic limb amputations, and cardiovascular morbidity and mortality, each of which may be treatable using hemangioblast-derived therapies.  We have within our reach the opportunity to make a meaningful impact on the lives of these patients, while building a product pipeline that leverages off our core competencies relating to stem cells."

About Advanced Cell Technology, Inc.

Advanced Cell Technology, Inc. is a biotechnology company applying cellular technology in the field of regenerative medicine. For more information, visit

Forward-Looking Statements

Statements in this news release regarding future financial and operating results, future growth in research and development programs, potential applications of our technology, opportunities for the company and any other statements about the future expectations, beliefs, goals, plans, or prospects expressed by management constitute forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Any statements that are not statements of historical fact (including statements containing the words "will," "believes," "plans," "anticipates," "expects," "estimates," and similar expressions) should also be considered to be forward-looking statements. There are a number of important factors that could cause actual results or events to differ materially from those indicated by such forward-looking statements, including: limited operating history, need for future capital, risks inherent in the development and commercialization of potential products, protection of our intellectual property, and economic conditions generally. Additional information on potential factors that could affect our results and other risks and uncertainties are detailed from time to time in the company's periodic reports, including the report on Form 10-K for the year ended December 31, 2010.  Forward-looking statements are based on the beliefs, opinions, and expectations of the company's management at the time they are made, and the company does not assume any obligation to update its forward-looking statements if those beliefs, opinions, expectations, or other circumstances should change. Forward-looking statements are based on the beliefs, opinions, and expectations of the company's management at the time they are made, and the company does not assume any obligation to update its forward-looking statements if those beliefs, opinions, expectations, or other circumstances should change. There can be no assurance that the Company's clinical trials will be successful.


CEOcast, Inc., James Young, 212-732-4300

ACT Corporate Communications, Bill Douglass, 646-450-3615
Russo Partners, Martina Schwarzkopf, Ph.D., 212-845-4292

SOURCE Advanced Cell Technology, Inc.
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