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AACC Pilot Studies Begin to Measure What Is Normal in Children's Development
Date:7/30/2013

HOUSTON, July 30, 2013 /PRNewswire/ -- AACC's Pediatric Reference Range Committee (PRRC) is performing two pilot studies to establish crucial pediatric reference intervals as part of the National Children's Study. Researchers speaking at AACC's 2013 Annual Meeting will discuss preliminary findings from these studies and underscore their importance to improving pediatric healthcare. Without solid numbers to interpret lab results, clinicians don't have a clear picture of age-appropriate biochemical indicators of normal childhood development.

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Interpreting certain lab test results in children has been challenging due to the lack of pediatric reference intervals, which show the distribution of normal values in a diverse, healthy population. Hospitals have traditionally based reference ranges on values from hospitalized children, adjusted for outliers, and on small studies that have not yielded robust data. The AACC pilot studies will provide statistically reliable data that meets industry standards for establishing reference ranges.

"One of the problems that we've always had in children's hospitals is that you don't have healthy children in the hospital, so you can't comfortably use that data," said AACC PRRC chair and session moderator, Michael Bennett, PhD, FRCPath, director of the Michael J. Palmieri Metabolic Laboratory at Children's Hospital of Philadelphia and professor of pathology and laboratory medicine at the University of Pennsylvania School of Medicine. "With a large cohort of healthy children from across the country, the National Children's Study offers laboratorians a unique opportunity to develop good reference ranges and also to understand better how the biomarkers that we measure in our labs reflect normal childhood deve
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