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A step towards new vaccines for most important chicken parasite
Date:10/13/2011

Researchers funded by the Biotechnology and Biological Sciences Research Council (BBSRC), among others, have taken the first step in developing a new type of vaccine to protect chickens against coccidiosis, the most important parasite of poultry globally.

A vaccine of this type -- based on proteins from the coccidiosis bug rather than being derived from a live parasite -- could be produced on a larger scale than is currently possible so could be used to provide much more widespread protection to chicken flocks.

Protecting against animal diseases is going to play an important role in ensuring global food security.

The researchers have produced a much more detailed picture of how coccidiosis attacks chickens, uncovering the protein molecules which are secreted onto the surface of the coccidiosis-causing-parasite, Eimeria, that allow it to attach-to and invade cells in a chicken's gut. The scientists also found that when purified and used to inoculate chickens, one of these molecules provided the birds with some protection against coccidiosis and so shows promise as the basis of a new vaccine.

The research was carried out by an international team with funding from BBSRC, the Engineering and Physical Sciences Research Council (EPSRC), the Medical Research Council (MRC) and the Wellcome Trust. The research is published today (13 October) in the journal PLoS Pathogens and the UK-based research took place at Imperial College London, the Institute for Animal Health, the University of Oxford and the Royal Veterinary College.

Professor Fiona Tomley of the Royal Veterinary College said "Coccidiosis is the most important parasite of poultry globally. Conservative estimates by the EU put the annual worldwide cost of coccidiosis at over 1billion so controlling it is very important economically but it is also valuable for improving the health and welfare of chickens."

Currently, coccidiosis is treated with
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Contact: Mike Davies
mike.davies@bbsrc.ac.uk
01-793-414-694
Biotechnology and Biological Sciences Research Council
Source:Eurekalert

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