Navigation Links
A single VSOP can do a 'proton' magic!
Date:6/16/2008

International research group led by Yasushi Okamura, a professor in Japanese National Institute for Physiological Sciences, Okazaki, and Peter Larsson, a professor in Oregon Health & Science University, Oregon, US, found that a single protein of VSOP, Voltage Sensor Only Protein/ Hv1, can carry protons even without making a multimeric complex. Since VSOP is known to be expressed in phagocytes such as macrophage and neutrophil that remove infected pathogens, this finding may help to design new medications for enhancing the activities of innate immunity. They report this work in Proceeding National Academy of Sciences (published online on the week of June 16, 2008).

Usually, ion channels on cell membrane form a multimeric complex to make an assembling hole to carry ions though it. Surprisingly, the research group found that this VSOP protein forms a dimer but each single subunit can carry proton without any assembling hole. They concluded it by using the techniques of FRET (Fluorescence Resonance Energy Transfer) and biochemistry,

The VSOP keeps cell inside alkaline condition. This finding helps to understand how VSOP regulates pH condition during the process of removing pathogens such as fungi, bacteria and virus.

"It is still not clear that how proton can go through a single VSOP protein, but here we clearly showed that a single subunit of VSOP can carry protons without making any assembling hole. This finding may help to design new medications for promoting activities of innate immunity or prevention of abnormal state of immunity such as asthma", said Professor Okamura.


'/>"/>

Contact: Yasushi Okamura
yokamura@phys2.med.osaka-u.ac.jp
81-668-793-310
National Institute for Physiological Sciences
Source:Eurekalert  

Page: 1

Related biology technology :

1. Novare Announces First Ever Single Port Laparoscopic Kidney Removal (Nephrectomy) Using RealHand(TM) HD Instruments
2. NIH Announces Advanced Cell Technologys Single Cell Embryo Biopsy Technique as a Means to Derive Embryonic Stem Cells to be Considered for Federal Funding
3. BioNanomatrix Announces Issuance of Key Nanofluidics Patent Enabling Single Molecule Whole Genome Analysis
4. Genmab Amends Ofatumumab Pivotal Study in NHL to Single Arm Study
5. Quantum device traps, detects and manipulates the spin of single electrons
6. Thermo Fisher Scientific to Expand Manufacturing Operation for Single-Use Bioprocessing Containers
7. Worlds smallest radio uses single nanotube to pick up good vibrations
8. Model for the assembly of advanced, single-molecule-based electronic components developed at Pitt
9. Faster X-ray interferometers due to single-photon interference
10. Genzyme Receives European CE Mark for Single-Treatment Synvisc-One(TM)
11. Nanotechnology innovation may revolutionize gene detection in a single cell
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
A single VSOP can do a 'proton' magic!
(Date:6/27/2016)... ... 27, 2016 , ... Parallel 6 , the leading software as a ... Reach Virtual Patient Encounter CONSULT module which enables both audio and video telemedicine ... team. , Using the CONSULT module, patients and physicians can schedule a face to ...
(Date:6/27/2016)...  Liquid Biotech USA , ... Sponsored Research Agreement with The University of Pennsylvania ... cancer patients.  The funding will be used to ... clinical outcomes in cancer patients undergoing a variety ... employed to support the design of a therapeutic, ...
(Date:6/24/2016)... , June 24, 2016 Epic ... sensitively detects cancers susceptible to PARP inhibitors by ... tumor cells (CTCs). The new test has already ... therapeutics in multiple cancer types. Over ... DNA damage response pathways, including PARP, ATM, ATR, ...
(Date:6/23/2016)... (PRWEB) , ... June 23, 2016 , ... ... the release of its second eBook, “Clinical Trials Patient Recruitment and Retention Tips.” ... and retention in this eBook by providing practical tips, tools, and strategies for ...
Breaking Biology Technology:
(Date:4/15/2016)... , April 15, 2016 ... the,  "Global Gait Biometrics Market 2016-2020,"  report to ... http://photos.prnewswire.com/prnh/20160330/349511LOGO ) , ,The global gait biometrics ... of 13.98% during the period 2016-2020. ... angles, which can be used to compute factors ...
(Date:3/31/2016)... , March 31, 2016   ... ("LegacyXChange" or the "Company") LegacyXChange is excited ... of its soon to be launched online site for ... https://www.youtube.com/channel/UCyTLBzmZogV1y2D6bDkBX5g ) will also provide potential shareholders a ... DNA technology to an industry that is notorious for ...
(Date:3/23/2016)... WAKEFIELD, Massachusetts , March 23, 2016 ... kombiniert im Interesse erhöhter Sicherheit Gesichts- und ... Xura, Inc. (NASDAQ: MESG ... heute bekannt, dass das Unternehmen mit SpeechPro ... insbesondere aus der Finanzdienstleistungsbranche, wird die Möglichkeit ...
Breaking Biology News(10 mins):