Navigation Links
A single VSOP can do a 'proton' magic!
Date:6/16/2008

International research group led by Yasushi Okamura, a professor in Japanese National Institute for Physiological Sciences, Okazaki, and Peter Larsson, a professor in Oregon Health & Science University, Oregon, US, found that a single protein of VSOP, Voltage Sensor Only Protein/ Hv1, can carry protons even without making a multimeric complex. Since VSOP is known to be expressed in phagocytes such as macrophage and neutrophil that remove infected pathogens, this finding may help to design new medications for enhancing the activities of innate immunity. They report this work in Proceeding National Academy of Sciences (published online on the week of June 16, 2008).

Usually, ion channels on cell membrane form a multimeric complex to make an assembling hole to carry ions though it. Surprisingly, the research group found that this VSOP protein forms a dimer but each single subunit can carry proton without any assembling hole. They concluded it by using the techniques of FRET (Fluorescence Resonance Energy Transfer) and biochemistry,

The VSOP keeps cell inside alkaline condition. This finding helps to understand how VSOP regulates pH condition during the process of removing pathogens such as fungi, bacteria and virus.

"It is still not clear that how proton can go through a single VSOP protein, but here we clearly showed that a single subunit of VSOP can carry protons without making any assembling hole. This finding may help to design new medications for promoting activities of innate immunity or prevention of abnormal state of immunity such as asthma", said Professor Okamura.


'/>"/>

Contact: Yasushi Okamura
yokamura@phys2.med.osaka-u.ac.jp
81-668-793-310
National Institute for Physiological Sciences
Source:Eurekalert  

Page: 1

Related biology technology :

1. Novare Announces First Ever Single Port Laparoscopic Kidney Removal (Nephrectomy) Using RealHand(TM) HD Instruments
2. NIH Announces Advanced Cell Technologys Single Cell Embryo Biopsy Technique as a Means to Derive Embryonic Stem Cells to be Considered for Federal Funding
3. BioNanomatrix Announces Issuance of Key Nanofluidics Patent Enabling Single Molecule Whole Genome Analysis
4. Genmab Amends Ofatumumab Pivotal Study in NHL to Single Arm Study
5. Quantum device traps, detects and manipulates the spin of single electrons
6. Thermo Fisher Scientific to Expand Manufacturing Operation for Single-Use Bioprocessing Containers
7. Worlds smallest radio uses single nanotube to pick up good vibrations
8. Model for the assembly of advanced, single-molecule-based electronic components developed at Pitt
9. Faster X-ray interferometers due to single-photon interference
10. Genzyme Receives European CE Mark for Single-Treatment Synvisc-One(TM)
11. Nanotechnology innovation may revolutionize gene detection in a single cell
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
A single VSOP can do a 'proton' magic!
(Date:4/27/2016)... (PRWEB) , ... April 27, 2016 , ... ... Touch screen mobile devices with fingerprint recognition for secure access, voice recognition ... only a few ways consumers are interacting with biometrics technology today. But ...
(Date:4/27/2016)... ... 2016 , ... PathSensors, Inc., a leading environmental testing company, ... assist PathSensors in expanding the use of the company’s CANARY® technology in the ... for the detection of harmful pathogens, including a number of bacteria, viruses, toxins, ...
(Date:4/27/2016)... , April 27, 2016 ... research report with specific focus on US, EU, ... Japan , to the healthcare business intelligence ... library. Complete report on the Flow ... companies and supported with 282 tables and figures ...
(Date:4/26/2016)... , ... April 26, 2016 , ... Mr. Palmer created ... RPO, signing the first multi-million dollar, multi-year managed services contract in the U.S. intelligence ... Michael join our leadership team,” said John Younger, founder of Accolo. “We are ...
Breaking Biology Technology:
(Date:3/31/2016)... 31, 2016  Genomics firm Nabsys has completed a ... Barrett Bready , M.D., who returned to the company ... technical leadership team, including Chief Technology Officer, John ... Steve Nurnberg and Vice President of Software and Informatics, ... Dr. Bready served as CEO of Nabsys ...
(Date:3/22/2016)... March 22, 2016 ... Sensors Market for Consumer Industry by Type (Image, ... Application (Communication & IT, Entertainment, Home Appliances, ... Forecast to 2022", published by MarketsandMarkets, the ... to reach USD 26.76 Billion by 2022, ...
(Date:3/18/2016)... --> --> ... & Unmanned Vehicles, Physical infrastructure and Perimeter Surveillance & Detection ... border security market and the continuing migration crisis in the ... has led visiongain to publish this unique report, ... defence & security companies in the border security ...
Breaking Biology News(10 mins):