Navigation Links
A single VSOP can do a 'proton' magic!
Date:6/16/2008

International research group led by Yasushi Okamura, a professor in Japanese National Institute for Physiological Sciences, Okazaki, and Peter Larsson, a professor in Oregon Health & Science University, Oregon, US, found that a single protein of VSOP, Voltage Sensor Only Protein/ Hv1, can carry protons even without making a multimeric complex. Since VSOP is known to be expressed in phagocytes such as macrophage and neutrophil that remove infected pathogens, this finding may help to design new medications for enhancing the activities of innate immunity. They report this work in Proceeding National Academy of Sciences (published online on the week of June 16, 2008).

Usually, ion channels on cell membrane form a multimeric complex to make an assembling hole to carry ions though it. Surprisingly, the research group found that this VSOP protein forms a dimer but each single subunit can carry proton without any assembling hole. They concluded it by using the techniques of FRET (Fluorescence Resonance Energy Transfer) and biochemistry,

The VSOP keeps cell inside alkaline condition. This finding helps to understand how VSOP regulates pH condition during the process of removing pathogens such as fungi, bacteria and virus.

"It is still not clear that how proton can go through a single VSOP protein, but here we clearly showed that a single subunit of VSOP can carry protons without making any assembling hole. This finding may help to design new medications for promoting activities of innate immunity or prevention of abnormal state of immunity such as asthma", said Professor Okamura.


'/>"/>

Contact: Yasushi Okamura
yokamura@phys2.med.osaka-u.ac.jp
81-668-793-310
National Institute for Physiological Sciences
Source:Eurekalert  

Page: 1

Related biology technology :

1. Novare Announces First Ever Single Port Laparoscopic Kidney Removal (Nephrectomy) Using RealHand(TM) HD Instruments
2. NIH Announces Advanced Cell Technologys Single Cell Embryo Biopsy Technique as a Means to Derive Embryonic Stem Cells to be Considered for Federal Funding
3. BioNanomatrix Announces Issuance of Key Nanofluidics Patent Enabling Single Molecule Whole Genome Analysis
4. Genmab Amends Ofatumumab Pivotal Study in NHL to Single Arm Study
5. Quantum device traps, detects and manipulates the spin of single electrons
6. Thermo Fisher Scientific to Expand Manufacturing Operation for Single-Use Bioprocessing Containers
7. Worlds smallest radio uses single nanotube to pick up good vibrations
8. Model for the assembly of advanced, single-molecule-based electronic components developed at Pitt
9. Faster X-ray interferometers due to single-photon interference
10. Genzyme Receives European CE Mark for Single-Treatment Synvisc-One(TM)
11. Nanotechnology innovation may revolutionize gene detection in a single cell
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
A single VSOP can do a 'proton' magic!
(Date:5/22/2017)... (PRWEB) , ... May 22, 2017 , ... ... today that it is exhibiting in booth B2 at the Association for ... May 22-25. , In addition to demonstrating its Cancer Diagnostic Cockpit and ...
(Date:5/18/2017)... ... May 18, 2017 , ... ... April 28, 2017 at the Prince Of Wales Private Hospital. The procedure was ... level C6-C7. The patient failed conservative treatments prior to undergoing surgery. , The ...
(Date:5/18/2017)... Massachusetts (PRWEB) , ... May 17, 2017 , ... ... company specializing in medical device compliance and commercialization, has just released version 9.0 ... of work into this latest version of Cockpit,” says David Cronin, CEO of ...
(Date:5/18/2017)... , ... May 18, 2017 , ... When James Sherley, was notified earlier this year ... Valuable Brands for the Year 2017 by The Silicon Review , he was not ... good progress increasing Asymmetrex’s value, but this recognition by Silicon Valley was particularly meaningful. ...
Breaking Biology Technology:
(Date:4/4/2017)... 4, 2017   EyeLock LLC , a leader ... United States Patent and Trademark Office (USPTO) has issued ... linking of an iris image with a face image ... the company,s 45 th issued patent. ... timely given the multi-modal biometric capabilities that have recently ...
(Date:3/30/2017)... Trends, opportunities and forecast in this market ... (fingerprint, AFIS, iris recognition, facial recognition, hand geometry, vein ... use industry (government and law enforcement, commercial and retail, ... others), and by region ( North America ... Pacific , and the Rest of the World) ...
(Date:3/24/2017)... Controller General of Immigration from Maldives Mr. Mohamed Anwar and ... international IAIR Award for the most innovative high security ePassport and eGates  ... ... Maldives Immigration Controller General, Mr. Mohamed Anwar ... right) have received the IAIR award for the "Most innovative high security ...
Breaking Biology News(10 mins):