Navigation Links
A single VSOP can do a 'proton' magic!

International research group led by Yasushi Okamura, a professor in Japanese National Institute for Physiological Sciences, Okazaki, and Peter Larsson, a professor in Oregon Health & Science University, Oregon, US, found that a single protein of VSOP, Voltage Sensor Only Protein/ Hv1, can carry protons even without making a multimeric complex. Since VSOP is known to be expressed in phagocytes such as macrophage and neutrophil that remove infected pathogens, this finding may help to design new medications for enhancing the activities of innate immunity. They report this work in Proceeding National Academy of Sciences (published online on the week of June 16, 2008).

Usually, ion channels on cell membrane form a multimeric complex to make an assembling hole to carry ions though it. Surprisingly, the research group found that this VSOP protein forms a dimer but each single subunit can carry proton without any assembling hole. They concluded it by using the techniques of FRET (Fluorescence Resonance Energy Transfer) and biochemistry,

The VSOP keeps cell inside alkaline condition. This finding helps to understand how VSOP regulates pH condition during the process of removing pathogens such as fungi, bacteria and virus.

"It is still not clear that how proton can go through a single VSOP protein, but here we clearly showed that a single subunit of VSOP can carry protons without making any assembling hole. This finding may help to design new medications for promoting activities of innate immunity or prevention of abnormal state of immunity such as asthma", said Professor Okamura.


Contact: Yasushi Okamura
National Institute for Physiological Sciences

Page: 1

Related biology technology :

1. Novare Announces First Ever Single Port Laparoscopic Kidney Removal (Nephrectomy) Using RealHand(TM) HD Instruments
2. NIH Announces Advanced Cell Technologys Single Cell Embryo Biopsy Technique as a Means to Derive Embryonic Stem Cells to be Considered for Federal Funding
3. BioNanomatrix Announces Issuance of Key Nanofluidics Patent Enabling Single Molecule Whole Genome Analysis
4. Genmab Amends Ofatumumab Pivotal Study in NHL to Single Arm Study
5. Quantum device traps, detects and manipulates the spin of single electrons
6. Thermo Fisher Scientific to Expand Manufacturing Operation for Single-Use Bioprocessing Containers
7. Worlds smallest radio uses single nanotube to pick up good vibrations
8. Model for the assembly of advanced, single-molecule-based electronic components developed at Pitt
9. Faster X-ray interferometers due to single-photon interference
10. Genzyme Receives European CE Mark for Single-Treatment Synvisc-One(TM)
11. Nanotechnology innovation may revolutionize gene detection in a single cell
Post Your Comments:
Related Image:
A single VSOP can do a 'proton' magic!
(Date:10/13/2015)... October 13, 2015      Q ... company, has entered into a strategic relationship with Wombat ... and Paris, France based strategic ... --> This collaborative arrangement gives Q BioMed ... advisory team as well as long established pharmaceutical industry ...
(Date:10/13/2015)... (PRWEB) , ... October 13, 2015 , ... Clinovo recently ... expertise to the company’s fast growing clinical data solutions business. , Jeff Parr has ... companies of all sizes, including Avery Dennison, Thermo Fisher, and Ab Sciex to name ...
(Date:10/12/2015)... BRUSSELS , Oct. 12, 2015  Amgen (NASDAQ: ... additional findings from an exploratory sub-study of the previously reported ... today in an oral plenary session at the American Society ... Seattle . 2 ... small exploratory sub-study data showed that, at month 12, the ...
(Date:10/12/2015)... October 12, 2015 cell surface marker ... by 2022, according to a new report by Grand View ... rise in incidence of oncology diseases and other cell-associated disorders. ... expected to reach USD 6.49 billion by 2022, according to ... in demand can be attributed to rise in incidence of ...
Breaking Biology Technology:
(Date:10/12/2015)... October 12, 2015 NXTD ) ("NXT-ID" ... growing mobile commerce market, reports on the recent SNS Future ... . --> NXTD ) ("NXT-ID" or the "Company"), ... market, reports on the recent SNS Future in Review Conference ... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or the ...
(Date:10/8/2015)... LAKE CITY , 8. Oktober 2015 ... TRCK), ein global tätiges Unternehmen des Bereiches ... einem Vertrag mit der Gefängnisbehörde Virginias (Department ... dessen Rahmen elektronische Überwachungsdienste für alle Strafen ... Derek Cassell , Präsident für den ...
(Date:10/6/2015)... 2015 Track Group, Inc. (OTCQX: TRCK), a ... signed a contract with the Virginia Department of Corrections ... of sentences under the Department,s oversight. Derek ... contract with the Virginia DOC will expand our footprint ... our position as a trusted leader in offender electronic ...
Breaking Biology News(10 mins):