Navigation Links
A molecule central to diabetes is uncovered
Date:8/8/2012

At its most fundamental level, diabetes is a disease characterized by stress -- microscopic stress that causes inflammation and the loss of insulin production in the pancreas, and system-wide stress due to the loss of that blood-sugar-regulating hormone.

Now, researchers led by scientists at the University of California, San Francisco (UCSF) have uncovered a new key player in amplifying this stress in the earliest stages of diabetes: a molecule called thioredoxin-interacting protein (TXNIP). The molecule, they've discovered, is central to the inflammatory process that leads to the death of the cells in the human pancreas that produce insulin.

"This molecule does something remarkable -- it takes stress and makes it worse," said the senior author of the study, UCSF's Feroz Papa, MD, PhD, an associate professor of medicine at UCSF and a member of the UCSF Diabetes Center and the California Institute for Quantitative Biosciences (QB3).

The study is published this week in the journal Cell Metabolism, with a parallel study by researchers at Washington University in St. Louis. Both studies were funded by the Juvenile Diabetes Research Foundation (JDRF).

The work provides a roadmap for finding new drugs that could target and shut down the action of TXNIP, thus preventing or stalling the inflammatory processes it amplifies. Researchers in the field believe that this strategy could benefit people in the early days of the disease, when diabetes is first developing or is soon to develop -- a time referred to as the "honeymoon" period.

Clinical studies have already shown that dietary changes and other approaches can extend the honeymoon period in some people and prevent diabetes in others. The overarching goal of Papa's research, he said, is to find a way to extend this honeymoon period indefinitely.

Diabetes and the Loss of Beta Cells

Diabetes is a major health concern in the United States, affe
'/>"/>

Contact: Jason Socrates Bardi
jason.bardi@ucsf.edu
415-502-6397
University of California - San Francisco
Source:Eurekalert  

Page: 1 2 3 4

Related biology technology :

1. In new quantum-dot LED design, researchers turn troublesome molecules to their advantage
2. Quanterix Develops Microfluidic Consumable That Will Enable Next Generation Molecular Diagnostic Systems based on Single Molecule Array Technology
3. LoneStar Heart Acquires Worldwide Exclusive Rights to New Class of Small Molecules That May Lead to New Treatments for Diabetes
4. Researchers capture first-ever images of atoms moving in a molecule
5. Single molecules in a quantum movie
6. Computer-designed molecules point to new therapy for cystic fibrosis
7. Discarded data may hold the key to a sharper view of molecules
8. Study improves understanding of surface molecules in controlling size of gold nanoparticles
9. Metamolecules that switch handedness at light-speed
10. Mending a broken heart -- with a molecule that turns stem cells into heart cells
11. Breaking Study: ICU Medicals Tego® Needlefree Connector Proves More Cost Effective Than Traditional Central Venous Catheter Locks
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
A molecule central to diabetes is uncovered
(Date:12/19/2014)... CAMBRIDGE, MA (PRWEB) December 18, 2014 ... adults in the United States suffer from one or ... arthritis, asthma, or cancer. Medication can address some of ... to daily activities that many sufferers face. While implanted ... surgery and stimulate the whole nerve, which can induce ...
(Date:12/19/2014)... The empty capsules market is ... population and technological innovations in the empty capsules ... catalysing the growth of the empty capsules market. ... , Scope of Report , The report will ... entrants/smaller firms to gauge the pulse of the ...
(Date:12/19/2014)... -- Egenix, Inc. is pleased to announce that Lionel ... to succeed Donald Fresne ; Mr. Fresne has also ... member of the Board.  In recognition of the many contributions ... almost twenty years, the Board designated Mr. Fresne as Chairman ... a Search Committee to find a suitable replacement with Biotech ...
(Date:12/17/2014)... 2014 The Activated Carbon Manufacturing ... is why IBISWorld updated its original industry research report. ... from an intensified focus on environmental policy. Over the ... standards for power plants and a range of other ... Industry Analyst Sarah Kahn, “a range of downstream industrial ...
Breaking Biology Technology:Draper Wins GSK Funding for Smaller, Smarter Implantable Devices 2Empty Capsules Market Hit to Reach $1,820 Million by 2019 - New Research Report by MarketsandMarkets 2Empty Capsules Market Hit to Reach $1,820 Million by 2019 - New Research Report by MarketsandMarkets 3Empty Capsules Market Hit to Reach $1,820 Million by 2019 - New Research Report by MarketsandMarkets 4Activated Carbon Manufacturing in the US Industry Market Research Report Has Been Updated from IBISWorld 2Activated Carbon Manufacturing in the US Industry Market Research Report Has Been Updated from IBISWorld 3
... ... distribution partner for the Taiwanese market. Uni-Onward,s recent focus on USP/NF grade chemicals is ... lab chemicals distributor in Taiwan and has built an outstanding reputation since its establishment ... ...
... Researchers from Rensselaer Polytechnic Institute have developed a ... strength of infrared imaging and could lead to a ... By leveraging the unique properties of nanoscale gold ... of the device, the researchers have doubled the detectivity ...
... OriGene Technologies, Inc. with the support of Wuxi Biopharmaceutical R&D ... and most sophisticated monoclonal antibody production centers in the world in Wuxi, ... have over one thousand employees with the capacity to produce over 20,000 ... , ...
Cached Biology Technology:Spectrum Announces Uni-Onward as its Taiwanese Distributor 2Nanotech discovery at Rensselaer could lead to breakthrough in infrared satellite imaging technology 2Nanotech discovery at Rensselaer could lead to breakthrough in infrared satellite imaging technology 3OriGene Technologies, Inc. to Build the World's Largest TrueMAB(TM) Monoclonal Antibody Facility in Wuxi, China 2
(Date:12/17/2014)... 16, 2014  Automation is fundamentally transforming the ... than at international borders. Over the past decade, ... allowed veteran travelers to self process through border ... Kiosks at an increasing number of airports, seaports, ... According to Maxine Most , Principal ...
(Date:12/11/2014)... , Dec. 09, 2014 Research and ... ( http://www.researchandmarkets.com/research/9ql3kr/biometrics_market ) has ... in India 2015-2019" report to their offering. ... this market is the adoption of multimodal biometric ... characteristic of an individual for verification and identification ...
(Date:12/10/2014)... You,ve been here before: you desperately need to sign into ... key or the answer to your secret question. What,s your ... Today, Hoyos Labs , a digital infrastructure security ... an end to the frustration that comes with usernames, passwords ... a user,s smartphone to acquire his or her biometrics to ...
Breaking Biology News(10 mins):Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 3
... 1st issue of G&D, Drs. Yong Sun Lee and Anindya ... in vitro. , "Overexpression of HMGA2 is an important ... Dutta. “It is very exciting to realize that microRNAs have ... so may have a role in the causation and perhaps ...
... blockbuster "Finding Nemo" when a school of fish makes a rapid ... other intricate designs. While the detailed shapes might be a bit ... how does a school of fish or a flock of birds ... reorganize as a unit, without knowing what the entire group is ...
... K. Long, MD, an endocrinology research fellow at the ... California, San Francisco, was one of only three scientists ... the National Space Biomedical Research Institute (NSBRI). , Long's ... possible methods of treating or preventing bone loss resulting ...
Cached Biology News:University of Alberta researchers unravel intricate animal patterns 2University of Alberta researchers unravel intricate animal patterns 3Researcher to study astronaut bone loss for space biology agency 2Researcher to study astronaut bone loss for space biology agency 3
... Zyagen tissue microarrays are derived from ... to rigorous quality control procedures to ensure ... are manually assembled in one block, sectioned ... mounted on coated slides. Sections are large ...
...
... consist of seven reduced, denatured proteins (equine ... rabbit muscle GAPDH, bovine muscle actin, BSA, ... ranging from 4.5 to 8.5 and molecular ... 2-D standards provide calibrated references for the ...
... tube gel adaptors, 24 glass tubes ... grommets, stoppers. The PROTEAN II xi cell ... the versatility to perform a variety of ... electrophoresis, native, preparative, and gradient PAGE as ...
Biology Products: