Navigation Links
A molecule central to diabetes is uncovered
Date:8/8/2012

At its most fundamental level, diabetes is a disease characterized by stress -- microscopic stress that causes inflammation and the loss of insulin production in the pancreas, and system-wide stress due to the loss of that blood-sugar-regulating hormone.

Now, researchers led by scientists at the University of California, San Francisco (UCSF) have uncovered a new key player in amplifying this stress in the earliest stages of diabetes: a molecule called thioredoxin-interacting protein (TXNIP). The molecule, they've discovered, is central to the inflammatory process that leads to the death of the cells in the human pancreas that produce insulin.

"This molecule does something remarkable -- it takes stress and makes it worse," said the senior author of the study, UCSF's Feroz Papa, MD, PhD, an associate professor of medicine at UCSF and a member of the UCSF Diabetes Center and the California Institute for Quantitative Biosciences (QB3).

The study is published this week in the journal Cell Metabolism, with a parallel study by researchers at Washington University in St. Louis. Both studies were funded by the Juvenile Diabetes Research Foundation (JDRF).

The work provides a roadmap for finding new drugs that could target and shut down the action of TXNIP, thus preventing or stalling the inflammatory processes it amplifies. Researchers in the field believe that this strategy could benefit people in the early days of the disease, when diabetes is first developing or is soon to develop -- a time referred to as the "honeymoon" period.

Clinical studies have already shown that dietary changes and other approaches can extend the honeymoon period in some people and prevent diabetes in others. The overarching goal of Papa's research, he said, is to find a way to extend this honeymoon period indefinitely.

Diabetes and the Loss of Beta Cells

Diabetes is a major health concern in the United States, affe
'/>"/>

Contact: Jason Socrates Bardi
jason.bardi@ucsf.edu
415-502-6397
University of California - San Francisco
Source:Eurekalert  

1

GOOD

Page: 1 2 3 4

Related biology technology :

1. In new quantum-dot LED design, researchers turn troublesome molecules to their advantage
2. Quanterix Develops Microfluidic Consumable That Will Enable Next Generation Molecular Diagnostic Systems based on Single Molecule Array Technology
3. LoneStar Heart Acquires Worldwide Exclusive Rights to New Class of Small Molecules That May Lead to New Treatments for Diabetes
4. Researchers capture first-ever images of atoms moving in a molecule
5. Single molecules in a quantum movie
6. Computer-designed molecules point to new therapy for cystic fibrosis
7. Discarded data may hold the key to a sharper view of molecules
8. Study improves understanding of surface molecules in controlling size of gold nanoparticles
9. Metamolecules that switch handedness at light-speed
10. Mending a broken heart -- with a molecule that turns stem cells into heart cells
11. Breaking Study: ICU Medicals Tego® Needlefree Connector Proves More Cost Effective Than Traditional Central Venous Catheter Locks
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
A molecule central to diabetes is uncovered
(Date:5/16/2013)... (PRWEB) May 16, 2013 The ... by Global Cooling, Inc., Athens, OH, USA, won the ... by the International Society for Biological and Environmental Repositories ... award, given to one product annually, recognizes the company’s ... ultra-low temperature freezer. The award was presented to ...
(Date:5/16/2013)... 16, 2013 A new selection ... from Cole-Parmer is designed to meet the dynamic ... , The new Cole-Parmer® MS-3400 Centrifuges ... the lab. They ensure a powerful and complete ... separation. Their standard four-place swinging buckets hold 50-mL ...
(Date:5/16/2013)... SAN DIEGO , May 16, 2013  The ... the Association of Bioscience Financial Officers (ABFO) 2013 National Conference, ... will be held May 28-31 at the Hilton San ... finishing touches on this year,s conference and want to ... opportunity to attend," said Brandi Roberts ...
(Date:5/16/2013)... , May 16, 2013 /PRNewswire/ ... market research report is available in ... Competitor Analysis: Therapeutic Proteins ... http://www.reportlinker.com/p01171947/Competitor-Analysis-Therapeutic-Proteins-–-Biosimilars-Biobetters--Biosuperiors.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Biopharmaceutical   ...   The new Competitive ...
Breaking Biology Technology:Stirling Ultracold Ultra-Low Freezer Wins 2013 Outstanding New Product Award at International Biorepository Conference, Sydney, Australia 2Cole-Parmer Offers Enhanced Selection of Centrifuges 2Registration Extended Until May 22 for Association of Bioscience Financial Officers (ABFO) 2013 National Conference -- San Diego 2Registration Extended Until May 22 for Association of Bioscience Financial Officers (ABFO) 2013 National Conference -- San Diego 3Registration Extended Until May 22 for Association of Bioscience Financial Officers (ABFO) 2013 National Conference -- San Diego 4Competitor Analysis: Therapeutic Proteins - Biosimilars, Biobetters & Biosuperiors 2Competitor Analysis: Therapeutic Proteins - Biosimilars, Biobetters & Biosuperiors 3Competitor Analysis: Therapeutic Proteins - Biosimilars, Biobetters & Biosuperiors 4Competitor Analysis: Therapeutic Proteins - Biosimilars, Biobetters & Biosuperiors 5Competitor Analysis: Therapeutic Proteins - Biosimilars, Biobetters & Biosuperiors 6Competitor Analysis: Therapeutic Proteins - Biosimilars, Biobetters & Biosuperiors 7Competitor Analysis: Therapeutic Proteins - Biosimilars, Biobetters & Biosuperiors 8
... Inc., a biotechnology company delivering breakthrough therapies in central ... will be participating at two upcoming healthcare investor conferences. ... at the 2nd Annual BIO Venture Conference on April ... Hotel in Boston, MA. On April 9 at 11:30 ...
... Inc., (OTC Bulletin Board: IXSBF; TSX VENTURE: IXS; ... generation of monoclonal antibodies based on its Dynamic Cross ... Company has entered into a loan facility with a ... to USD$2.5 million. The loan facility, subject to final ...
... March 25 Human Genome Sciences, Inc. (Nasdaq: ... subsidiary of Eisai Corporation of North America, today ... to discover, develop and commercialize therapeutic monoclonal antibodies ... specifically target antigens discovered by HGS.(Logo: http://www.newscom.com/cgi-bin/prnh/20080416/HGSLOGO ...
Cached Biology Technology:Accera, Inc. to Present at Upcoming Investor Conferences 2InNexus Biotechnology Announces a Loan Facility of up to USD$2.5 Million 2Human Genome Sciences and Morphotek(R), Inc. Announce Collaboration to Discover, Develop and Commercialize Antibodies for Oncology and Immunology 2Human Genome Sciences and Morphotek(R), Inc. Announce Collaboration to Discover, Develop and Commercialize Antibodies for Oncology and Immunology 3Human Genome Sciences and Morphotek(R), Inc. Announce Collaboration to Discover, Develop and Commercialize Antibodies for Oncology and Immunology 4Human Genome Sciences and Morphotek(R), Inc. Announce Collaboration to Discover, Develop and Commercialize Antibodies for Oncology and Immunology 5
(Date:5/16/2013)... scientists have shown a gene involved in neurodegenerative disease ... of the circadian clock. , In a study ... gene, called Ataxin-2, keeps the clock responsible for sleeping ... the rhythm of the fruit fly,s sleep-wake cycle is ... for the fly. , The discovery is particularly ...
(Date:5/16/2013)... 16, 2013 Integrated Biometrics patented LES ... custom thin film transistor camera introduces Sherlock, a ... image in the smallest and lightest form factor ... F Mobile ID FAP 45, Certified scanner is ... size and weight when compared to optical scanners. ...
(Date:5/16/2013)... neuroscientists from Canada and around the world are ... Canadian Neuroscience Meeting will showcase the latest in ... and reveal clues to understanding the disorders that ... research, and this meeting will showcase the best ... world," says Sam David, President of the Canadian ...
Breaking Biology News(10 mins):Gene involved in neurodegeneration keeps clock running 27th Annual Canadian Neuroscience Meeting, Toronto, May 20-24, 2013 2
... could create an evolutionary express lane that leads to the ... Pittsburgh and the University of Wisconsin at Madison have found. ... National Academy of Sciences ( PNAS ) that slight ... the when, where, and how much in gene productioncan activate ...
... University study has found that sunlight decreases the toxicity of ... United States every year. While golden algae is primarily ... and lakes, including Lake Whitney and Lake Waco in Central ... several environmental factors influence toxin production, but new research from ...
... Alexandria, VA The International and American Associations for ... symposium themed "Tissue Injury and Pulp Regeneration," held in ... the IADR Pulp Biology and Regeneration Group, and they ... Advances in Dental Research, an E-supplement to the ...
Cached Biology News:Leaky genes put evolution on the fast track, Pitt and UW-Madison researchers find 2IADR/AADR publish proceedings from Symposium on Tissue Injury and Pulp Regeneration 2
... sheer in-house demand is causing shortages in your ... This can cause unwanted distractions, problems and delays. ... your hard work and endeavour! Bring us your ... market it internationally. We work under ISO 9001 ...
... sheer in-house demand is causing shortages in your ... This can cause unwanted distractions, problems and delays. ... your hard work and endeavour! Bring us your ... market it internationally. We work under ISO 9001 ...
Topoisomerase I...
...
Biology Products: