Navigation Links
A milestone in nanoparticle research: Nanoparticle test handbook sets the standards

This press release is available in German and French.

The new standard work is intended to bring to an end to the confusing mishmash of jargon which currently prevails in the nanoresearch field. This, at any rate, is Harald Krug's assessment of the situation. Krug is a member of the Empa Board of Directors and a nanoparticle specialist. In the past few years the number of publications on nanotoxicology has increased dramatically, from 150 scientific papers in 2004 to 1800 last year. And yet Krug has determined that, in describing the material being studied, every author defines things in their own way. "To date only the names of the substances being investigated are reported, such as zinc oxide," Krug criticizes. "But in what form do the nanoparticles occur? Are they spheres? Cylinders? Or ultrafine needles? Does the material contained traces of catalysts in addition to zinc oxide? Has it been given a coating to stabilize its surface?" In many publications all these questions and more remain unanswered, which means that the results of the research work are not comparable with other studies and therefore of no value.

Exact regulations with an update method

The new fundamental reference work, named the Quality Handbook and subtitled Standard Procedures for Nanoparticle Testing, is intended to provide a common scientific basis for European research projects in the nanomaterials field. The document was put together by the Nanommune consortium, a group of European and US research institutes, and financed by the European commission under the aegis of the 7th Framework Program. As editor of the handbook, Harald Krug was responsible for drawing the results of all his colleagues' work together.

The handbook contains over 80 so-called SOP's (Standard Operating Procedures). With the help of these instructions nanoparticles with defined properties can be synthesized in the laboratory. The SOPs also contain standardized analytical methods which can be used to characterize the physical and chemical properties of the particles as well as their biological effects.

Science never stands still, so a static book of regulations would have a very short period of usefulness before its contents became outdated. For this reason, the authors have made provision for future revisions of the new work even before its publication. "In a follow-on project (DaNa; a special SOP form is being prepared which will be used to provide feedback to the authors on improvements to the standardized methods," explains Krug. These improvements will then be integrated into future editions of the Quality Handbook.

Are nanoparticles dangerous?

The Nanommune research project, which lasted for three years, dealt with the toxicological characterization of industrially produced nanoparticles which are to a certain extent "designed" as opposed to naturally occurring nanoparticles such as fine dust. These synthetic nanoparticles have enormous potential to aid industrial growth and to making a significant contribution to enhancing the quality of life of billions of people. However, the risks involved in the use of nanoparticles have to date not been fully investigated. Nanoparticles are over 100 times smaller than a cell and therefore possibly not recognized by the human immune system. Where they accumulate, what paths they take through the body and what effects they have are all questions which are currently under study. There is no reason to panic, according to Krug, for although industrially produced nanoparticles have been used for several decades already, they are not known to have caused any detrimental health effects.

Contact: Professor Dr. Harald Krug
Swiss Federal Laboratories for Materials Science and Technology (EMPA)

Related biology technology :

1. Odyssey Thera Announces Milestone Achievement in Pfizer Alliance
2. Milestone to Report Results for 2008 Second Quarter on Thursday, August 14, 2008
3. Milestone Biosciences, LLC Further Strengthens Executive Management Team
4. Access Pharmaceuticals Licenses MuGard to Milestone Biosciences, LLC for North America
5. Genmab Reaches Fifth Milestone in Ofatumumab Collaboration
6. Teliks Aurora Kinase-VEGFR Dual Inhibitor Program Meets a Preclinical Development Milestone
7. InterMune Earns Development Milestone in HCV Protease Inhibitor Collaboration With Roche
8. Anesiva Announces Conference Call and Webcast to Discuss Updates to Corporate Strategy and Milestones
9. Cardica Receives $1 Million Milestone Payment From Cook Medical for Development of Heart Defect Closure Device
10. Cequent Pharmaceuticals Meets Novartis Option Fund Milestone; Continues to Next Phase to Validate Inflammatory Bowel Disease Targets in Vivo
11. BioMS Medical announces receipt of milestone payment from Eli Lilly and Company
Post Your Comments:
Related Image:
A milestone in nanoparticle research: Nanoparticle test handbook sets the standards
(Date:11/25/2015)... /PRNewswire/ - Aeterna Zentaris Inc. (NASDAQ:  AEZS; TSX: AEZ) ... remain fundamentally strong and highlights the following developments: ... DSMB recommendation to continue the ZoptEC Phase 3 ... final interim efficacy and safety data , ... with heavily pretreated castration- and Taxane-resistant prostate cancer ...
(Date:11/24/2015)... LUMPUR, Malaysia , Nov. 24, 2015 /PRNewswire/ ... global contract research organisation (CRO) market. The trend ... result in lower margins but higher volume share ... increased capacity and scale, however, margins in the ... Research Organisation (CRO) Market ( ), ...
(Date:11/24/2015)... (PRWEB) , ... November 24, 2015 , ... ... maintain healthy metabolism. But unless it is bound to proteins, copper is also ... Health (NIH), researchers at Worcester Polytechnic Institute (WPI) will conduct a systematic study ...
(Date:11/24/2015)... ... November 24, 2015 , ... This fall, global software solutions leader SAP ... states to develop and pitch their BIG ideas to improve health and wellness in ... for votes to win the title of SAP's Teen Innovator, an all-expenses paid trip ...
Breaking Biology Technology:
(Date:11/2/2015)... PARK, Calif. , Nov. 2, 2015  SRI ... $9 million to provide preclinical development services to the ... the contract, SRI will provide scientific expertise, modern testing ... wide variety of preclinical pharmacology and toxicology studies to ... --> The PREVENT Cancer Drug Development ...
(Date:10/29/2015)... -- Connected health pioneer, Joseph C. Kvedar , MD, ... and wellness, and the business opportunities that arise from ... of Healthy Things . Long before health and ... Kvedar, vice president, Connected Health, Partners HealthCare, was creating ... from the hospital or doctor,s office into the day-to-day ...
(Date:10/27/2015)... SAN JOSE, Calif. , Oct. 27, 2015 /PRNewswire/ ... human interface solutions, today announced that Google has adopted ... family of touch controller solutions to power its newest ... Nexus 6P by Huawei. --> ... ecosystem partners like Google to provide strategic collaboration in ...
Breaking Biology News(10 mins):