Navigation Links
A mathematical theory proposed by Alan Turing in 1952 can explain the formation of fingers
Date:7/31/2014

and so this remained as the critical unsolved piece of the puzzle. The new study completes the picture, by revealing which signaling molecules act as the Turing system" says James Sharpe, co-author of the study.

The approach taken was that of systems biology combining experimental work with computational modelling. In this way, the two equal-first authors of the paper were able to iterate between the empirical and the theoretical: the lab-work of Jelena Raspopovic providing experimental data for the model, and the computer simulations of Luciano Marcon making predictions to be tested back in the lab.

By screening for the expression of many different genes, they found that two signalling pathways stood out as having the required activity patterns: BMPs and WNTs. They gradually constructed the minimal possible mathematical model compatible with all the data, and found that the two signalling pathways were linked through a non-diffusible molecule the transcription factor Sox9. Finally, they were able to make computational predictions about the effects of inhibiting these 2 pathways either individually, or in combination which predicted how the pattern of fingers should change. Strikingly, when the same experiments were done on small pieces of limb bud tissue cultured in a petri dish the same alterations in embryonic finger pattern were observed, confirming the computational prediction.

This result answers a long-standing question in the field, but it has consequences that go beyond the development of fingers. It addresses a more general debate about how the millions of cells in our bodies are able to dynamically arrange themselves into the correct 3D structures, for example in our kidneys, hearts and other organs. It challenges the dominance of an important traditional idea called positional information, proposed by Lewis Wolpert which states that cells know what to do because they all receive information about their "coordinates" in s
'/>"/>

Contact: Juan Manuel Sarasua
juan.sarasua@crg.eu
34-934-160-159
Center for Genomic Regulation
Source:Eurekalert  

Page: 1 2 3

Related biology technology :

1. Penn research helps lay out theory for metamaterials that act as an analog computer
2. Surprise: Viruses Can Cause Disease during Latent Phase; New Evidence Supports Microcompetition Theory
3. Enteroviruses Cause Type 1 Diabetes; New Studies Support Dr. Hanan Polansky’s Microcompetition Theory
4. Surprise: Flu Vaccine Prevents Heart Attacks and Strokes; New Study on Flu Vaccine Supports Dr. Hanan Polansky’s Microcompetition Theory
5. Scientific Proceedings Published, Challenging Conventional Neo-Darwinian Theory
6. Orlando Holistic Medicine and Wellness Center Releases Conspiracy Theory Thriller Book
7. 31st International Symposium on Lattice Field Theory
8. Major grant to investigate limits of quantum theory
9. Maths experts question key ecological theory
10. Rice professors nanotube theory confirmed
11. Microlin Bio Files Registration Statement for $25,000,000 Proposed Initial Public Offering
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
A mathematical theory proposed by Alan Turing in 1952 can explain the formation of fingers
(Date:10/30/2014)... 2014 The report “Fragrance Ingredients Market ... (Cosmetics & Toiletries, and Soaps & Detergents) & by ... defined and segmented the Fragrance Ingredients Market with analyses ... of value. The market has been segmented on the ... Asia-Pacific, Latin America, and Rest of the World (ROW); ...
(Date:10/30/2014)... October 30, 2014 2014 Deep ... Industry” is a professional and in-depth research report ... basic Naltrexone HCL information, including its definition, classification, ... industry overview. This research covers the international market ... global industry analysis covering macroeconomic environment & economic ...
(Date:10/30/2014)... 2014 James Sherley says he has been ... stem cell technology since his days as a principal investigator ... the late 1990’s. Sherley founded the ASCTC as a ... all the intellectual property developed in Sherley’s research over the ... Institute of Technology (MIT), and more recently as a senior ...
(Date:10/30/2014)... Ras Al Khaimah, UAE (PRWEB) October 30, 2014 ... the appointment of Dr. James A. Manganello, Chairman of the ... (NSCEC) of The Bahamas. The appointment was made by ... The Bahamas on September 24th, 2014. , More ... Cell Therapy and Research Bill , Prime Minister Perry Christie ...
Breaking Biology Technology:Fragrance Ingredients Market worth $17,104.21 Million by 2019 - New Report by MarketsandMarkets 2Fragrance Ingredients Market worth $17,104.21 Million by 2019 - New Report by MarketsandMarkets 3Fragrance Ingredients Market worth $17,104.21 Million by 2019 - New Report by MarketsandMarkets 4Fragrance Ingredients Market worth $17,104.21 Million by 2019 - New Report by MarketsandMarkets 5Naltrexone HCL Market & Nalbuphine HCL Industry Analysis for Global, China Regions Now at DeepResearchReports.com 2Naltrexone HCL Market & Nalbuphine HCL Industry Analysis for Global, China Regions Now at DeepResearchReports.com 3Boston’s Adult Stem Cell Technology Center, LLC Introduces A New Technology for Monitoring Previously Elusive Adult Stem Cells 2Boston’s Adult Stem Cell Technology Center, LLC Introduces A New Technology for Monitoring Previously Elusive Adult Stem Cells 3Boston’s Adult Stem Cell Technology Center, LLC Introduces A New Technology for Monitoring Previously Elusive Adult Stem Cells 4Grace Century’s Stem Cell Biobank Project Announces Chairman’s Appointment to National Stem Cell Ethics Committee of The Bahamas 2Grace Century’s Stem Cell Biobank Project Announces Chairman’s Appointment to National Stem Cell Ethics Committee of The Bahamas 3
... London, July 20 There has been a recent upsurge ... space. While the economic downturn and related credit crunch has had ... which has including four mega M&As in the first half of ... ) , , "The real intention ...
... , ... has added to its portfolio of topical hormonal modulators with the acquisition of a ... systemic activity and will be developed for skin and hair disorders associated with increased ... ...
... , SAN FRANCISCO, July 17 VIA ... focused on the development of compounds for the treatment of ... Staff Determination letter, dated July 15, 2009, from the NASDAQ ... with the minimum $2,500,000 stockholders, equity requirement for continued listing, ...
Cached Biology Technology:Big Pharma to Big Biopharma: Frost & Sullivan Examines the Latest M&A Trends and Opportunities 2Hygeia Therapeutics Signs an Exclusive License with Yale University for Potent, Safe Topical Anti-Androgens 2Hygeia Therapeutics Signs an Exclusive License with Yale University for Potent, Safe Topical Anti-Androgens 3VIA Pharmaceuticals Receives Anticipated Notice From NASDAQ 2VIA Pharmaceuticals Receives Anticipated Notice From NASDAQ 3VIA Pharmaceuticals Receives Anticipated Notice From NASDAQ 4
(Date:10/30/2014)... is available in German . ... prompt our fellow humans to behave socially? This is ... in game theory. Previous studies assumed that it is ... scientists from the Max Planck Institute for Evolutionary Biology ... an influence on the cooperative behaviour of others. However, ...
(Date:10/30/2014)... , Oct. 29, 2014  Securus Technologies, ... justice technology solutions for public safety, investigation, ... has deployed exciting enhancements to its THREADS™ ... to provide actionable intelligence and focused leads ... to drive technological innovation through identifying and ...
(Date:10/29/2014)... Online registration is open for the ... Scientific Meeting. SIR 2015 is the one ... trainees and related health care professionals can ... image-guided science and technologies being presented, discussed ... community in minimally invasive, image-guided medicine, SIR ...
Breaking Biology News(10 mins):Together we are strong -- or insufferable 2Together we are strong -- or insufferable 3Together we are strong -- or insufferable 4Securus Technologies Adds Advanced Features to Its Industry-Leading Investigative Analytics Product 2SIR 2015: Interventional radiology shapes tomorrow's medicine 2
... Capitol Hill, experts discussed how federally funded university research ... hearing, "Fueling Local Economies: Research, Innovation and Jobs," was ... by Rep. Carolyn Maloney (D-NY). Expert witnesses focused ... Samuel Stanley, president of Stony Brook University; Zachary Shulman, ...
... will present seven societal awards to distinguished ecologists at ... Pittsburgh. The meeting, which has the theme "Global Warming: ... future," draws a critical combination of more than 3,000 ... and consequences of global warming and to discuss the ...
... years as an herbal remedy to prevent or treat colds, ... medicines in North America. However, in spite of its popularity, ... immune system are conflicting. Now researchers from ... investigating the possibility that Echinacea has other potentially more important ...
Cached Biology News:NY state the focus of Congressional hearing on how research and innovation fuel local economies 2NY state the focus of Congressional hearing on how research and innovation fuel local economies 3Ecological Society of America announces 2010 award recipients 2Ecological Society of America announces 2010 award recipients 3Ecological Society of America announces 2010 award recipients 4
Mol wt: monoisotopic mol wt1,045.5423 Da by calculation...
Bis-Acrylamide (bis) is a monomer used as a crosslinker with acrylamide to form polyacrylamide electrophoretic gels. This 2% bis solution is supplied as 500 ml....
Anti-human VEGFR-2/KDR (Protein-A Purified) Polyclonal Antibody...
Mouse monoclonal antibody to Lats2....
Biology Products: