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A knockout resource for mouse genetics
Date:6/15/2011

e predicted and at well above the historical average," says Allan Bradley, senior author of the study and Director Emeritus of the Wellcome Trust Sanger Institute. "We have taken careful steps to ensure we deliver quality resources of maximum utility that will stand the test of time. Indeed, we expect our systems will be increasingly adopted by researchers using human and other cells to seek advances in the understanding of disease."

The methods the team have developed will also accelerate studies on human stem cells - cells that have the potential to grow into many different types of adult tissue. Research into producing such induced pluripotent stem cells from adult tissues (forgoing the need for embryonic stem cells) is expected to be vital in understanding human disease and therapies. The systems developed for mouse stem cells are transferable to human cells and could drive research into mutation in the human genome and its biological and medical consequences.

"Biomedical research needs biological resources on a scale that match genomics resources," explains Colin Fletcher, Ph.D., Program Director of the Knock Out Mouse Program at the National Institutes of Health, a part of the international knockout effort. "Such knockout resources are the foundation for producing thousands of valuable mouse mutants for future large-scale international phenotyping programmes and will serve the biological and biomedical research community worldwide."


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Contact: Don Powell
press.office@sanger.ac.uk
44-122-349-6928
Wellcome Trust Sanger Institute
Source:Eurekalert

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