Navigation Links
A hot road to new drugs
Date:2/24/2010

ted is mixed with a blood sample containing a target that is known to be associated with a disease state and has been labelled with a fluorescent tag. A tiny drop of the mixture is taken up into a thin glass capillary tube, and a focused beam of IR-laser light is used to heat a small volume of the solution in the middle of the tube. This gives rise to a temperature gradient that falls off towards the outside. The response of the labelled molecule to the variation in temperature can then be followed using fluorescence methods.

Upon heating of the sample, it immediately becomes apparent whether or not the fluorescent target-molecules in the sample behave differently in the presence of the drug test compound than they do in its absence. Any difference in thermophoresis between the two samples indicates that the test substance binds to the labelled target, and provides the first hint that it may have therapeutic potential. "Our method will not only be a boon to drug discovery", says Braun. "It can also be used in medical diagnostics, food testing and environmental monitoring. One could, for instance, employ it to diagnose autoimmune diseases and infections, or as the basis for a rapid test for the presence of antibiotics in milk or toxic substances in water." (NIM/suwe)


'/>"/>

Contact: Prof. Dieter Braun
49-892-180-2317
Ludwig-Maximilians-Universitt Mnchen
Source:Eurekalert

Page: 1 2

Related biology technology :

1. Novel Angiogenic Drugs, Including a Future Blockbuster from Genzyme, Could Revolutionize Treatment of Peripheral Arterial Disease
2. Isis Enters Broad Collaboration With Ortho-McNeil, Inc. for the Discovery, Development and Commercialization of Antisense Drugs to Treat Metabolic Diseases
3. Thomson Scientific Publishes Who Is Making The Biggest Splash? - A Quarterly Review of Scientific Literature on Drugs and Therapies From April - June 2007
4. Isis Pharmaceuticals and Thomas, McNerney & Partners Announce That the Newly Formed Altair Therapeutics Will Develop Antisense Drugs for Respiratory Conditions
5. First New Class of Platinum-Based Chemotherapy Drug Candidates in 30 Years Demonstrate Ability to Kill Tumors Resistant to Currently Marketed Platinum Drugs
6. So Long, Old Friend: The End of the Blockbuster Drug Era? What 2008 Holds for Bringing Drugs to Market
7. Drugs from Johnson & Johnson/Basilea and Forest Are the Most Promising Antibiotics in the Community-Acquired Pneumonia Pipeline
8. Amazing Treatment Relieves Serious Back Pain Without Dangerous Drugs, Injections or Surgery!
9. Human Genome Sciences and Aegera Therapeutics Announce Licensing and Collaboration Agreement on Novel Anti-Cancer Drugs
10. Research Using Thermo Fisher Scientific RNA-Interference Technology Unveils Potential New Targets for HIV Drugs
11. Pyratine-6(TM) Study Published in Journal of Drugs in Dermatology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/6/2015)... Wellesley, Mass. (PRWEB) , ... July 06, 2015 ... ... development of simpler and cheaper molecular diagnostic tests are key drivers of the ... projected growth of personalized medicine and the introduction of new companion diagnostic tests ...
(Date:7/5/2015)... , ... July 06, 2015 , ... For many years, ... user had a high-end machine such as a Varian Cary 4000-7000, a Perkin Elmer ... was this design that even NIST used them for their SRM-2031 series going back ...
(Date:7/3/2015)... WIEN , July 3, 2015 /PRNewswire/ ... fram till 22 september 2015 på  http://www.openinnovationinscience.at ... Open Innovation in Science" som hålls i ... Enligt en färsk undersökning med internationella forskare ... Gesellschaft (LBG) är hälsovetenskapens två största utmaningar ...
(Date:7/2/2015)... 2015 College of DuPage students Sam ... invaluable real-world experiences while serving biophysics internships at the ... The students will be working as a part of ... at IIT. The internship came about from a discussion ... Dr. Kathy Finan , Biology; and Dr. Wereszczynski ...
Breaking Biology Technology:Demand for Personalized Medicine, Innovative Molecular Diagnostic Tests Spurring Big Growth, According to BCC Research 2Demand for Personalized Medicine, Innovative Molecular Diagnostic Tests Spurring Big Growth, According to BCC Research 3FireflySci Simplifies the Calibration of UV Spectrophotometers with FUV Photometric Accuracy Standards 2FireflySci Simplifies the Calibration of UV Spectrophotometers with FUV Photometric Accuracy Standards 3Lansering av världens första program för öppen innovation för att utbilda forskare 2Lansering av världens första program för öppen innovation för att utbilda forskare 3COD Students Participate in Prestigious Summer Internships 2
... Feb. 6 GeoPharma, Inc. (Nasdaq:,GORX) (the "Company") announced ... wide of an audience as possible it has placed ... on its website at, http://www.GeoPharmainc.com under the "Analyst ... will be speaking publicly several times in,the next few ...
... NHS Choices ( http://www.nhs.uk ), the,online ,front door, ... calculator,to measure your body mass index (BMI)., ... http://www.nhs.uk/Tools/Pages/BMI.aspx ) enables users to calculate in,seconds what ... approved,guidance on maintaining or obtaining a healthy BMI. ...
... BioSpecifics,Technologies Corp. (OTC Bulletin Board: BSTC) announced today ... to it by its former CEO, Edwin H.,Wegman, who ... H. Wegman,repaid the loan amount plus accrued interest on ... BioSpecifics, common stock to certain private,investors. The Estate sold ...
Cached Biology Technology:Recent Research Reports and Near-Term Corporate Events 2Recent Research Reports and Near-Term Corporate Events 3
(Date:7/7/2015)... VIEW, Calif. , July 7, 2015 /PRNewswire/ ... biometrics market, Frost & Sullivan recognizes Credence ID, ... Sullivan Entrepreneurial Company of the Year Award. ... suite to aid in its mission of offering ... under-recognized populations globally. As Credence ID was formed ...
(Date:7/7/2015)... July 7, 2015 NXT-ID, Inc. (NASDAQ: NXTD ) ... growing mobile commerce market announces a revised version of one of ... commercial will air on CNBC in New York ... and San Francisco metro areas.    ... on Wocket,s ability to replace all the cards in your wallet ...
(Date:7/2/2015)... , June 25, 2015 ... announced the addition of the "Natural Language ... Technologies (Recognition, IVR, OCR, Pattern & Image Recognition) ... their offering. The key vendors occupying ... HP, IBM Corporation, Microsoft Corporation, NetBase Solutions, SAS ...
Breaking Biology News(10 mins):Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 2Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 3Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 4Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 5Wocket Smart Wallet Commercials Airing on CNBC to Showcase This Summer's Must- Have Tech Product 2Wocket Smart Wallet Commercials Airing on CNBC to Showcase This Summer's Must- Have Tech Product 3Natural Language Processing Market by Type (Rule-Based, Statistical, and Hybrid), Technologies (Recognition, IVR, OCR, Pattern & Image Recognition) - Worldwide Forecast to 2020 2
... under the windswept islands of the Aleutians, according to ... Alaska Fairbanks. This summer, while completing the second ... waters around the Aleutian Islands, scientists have discovered what ... surveyed the western region of the Aleutians, from Attu ...
... The National Science Foundation has awarded a $1.1 ... Light Microscopy core laboratory at the California NanoSystems ... acquisition of the first commercially available super-resolution stimulated ... nanoscopic resolution of biological samples. The device ...
... State University has announced a significant research partnership with ... develop a renewable source of biofuel. The ... bacterium to produce biodiesel, a sustainable high-energy fuel that ... This project illustrates the type of high impact research ...
Cached Biology News:Divers find new species in Aleutians 2Divers find new species in Aleutians 3$1.1 million NSF grant to fund research in advanced light microscopy at UCLA 2Arizona State University launches biofuel initiative with BP and Science Foundation Arizona 2Arizona State University launches biofuel initiative with BP and Science Foundation Arizona 3
... direct antibiotic-based selection system for recombinant identification. ... eliminating the need for costly color screening. ... to 100% accuracy in recombinant selection. pLivSelect ... colony picking. This cloning kit can be ...
... Nikon's NIS-Elements revolutionizes imaging software for ... intelligence to microscopes, cameras, components and ... and achiving tools. Its intuitive interface ... acquisition times while providing powerful features ...
Mouse monoclonal [IA-C6] to MHC Class II I Ab + Ad (FITC) ( Abpromise for all tested applications). Antigen: Tissue / cell preparation of Purified Mouse lymph node B cells...
...
Biology Products: