Navigation Links
A breakthrough toward industrial production of fluorescent nanodiamonds
Date:6/5/2009

The laboratory Structure - Activit of Normal & Pathologic Biomolecules SANPB , Inserm / UEVE U829 (Genopole Evry, France) in collaboration with the Material Centre of Mines-ParisTech (Evry, France), the NRG - UMR 5060 CNRS / UTBM (Technology University of Belfort-Montbliard) and the Physic Institute of Stuttgart University (Germany) discovered a novel route to fabricate fluorescent nanoparticles from diamond microcrystals. Results are published in Nanotechnology June10 2009 issue.

Fluorescence is a major tool in life and material sciences. In biology/medicine, the coupling of fluorescent dyes, to proteins or nucleic acids (RNA, DNA) allows one to investigate their fate and interactions in cultured cells or in the body. Similarly, fluorescence is used in material sciences to detect electromagnetic fields, for optic storage or tracking (notably to detect fake products). However, most of fluorescent dyes are made of molecules with a limited life time due to chemical reactivity.

In this context fluorescent diamond nanoparticles present a valuable alternative thanks to their outstanding photophysical properties. They are very bright and possess long-term non-bleaching, non-blinking fluorescence in the red/NIR region. Based on these unique properties, multiple applications are foreseen in physics, material science, biochemistry and biology. However, until recently, the production of such nanoparticles was limited to the laboratory.

A single route is nowadays taken to fabricate such fluorescent nanoparticles. It consists of irradiating substitutional nitrogen-containing diamond nanocrystals, produced by the diamond industry, with electron or ion beams to create vacancies in the crystal lattice. Isolated substitutional nitrogen atoms then trap a moving vacancy during annealing to form a fluorescent NV centre. Unfortunately, the efficiency and yield of this route are low due to amorphization and the loss of moving vacancies to the surface during irradiation and annealing.

A top-down processing of diamond microcrystals, which are less prone to amorphization and vacancy loss, would provide a more industrially scalable route. However, in this case two barriers have to be surmounted the difficulties of irradiating large amounts of material and converting microdiamonds into nanocrystals while keeping both fluorescence properties and crystal structure intact.

In a recent study, which is published in Nanotechnology, researchers in France and Germany have explored with success this alternative route to producing homogeneous samples of pure and very small fluorescent diamond nanoparticles with high yield. The fabrication procedure starts with the irradiation of finely controlled micron-size diamonds and requires subsequent milling and purification steps. In this novel process, substitutional nitrogen-containing microdiamonds with defined atomic composition were irradiated using a high-energy electron beam and then annealed at high temperature (800 C) to create the desired photoluminescent centres in an intact diamond lattice. An original two-step milling protocol was designed to convert the fluorescent microdiamond into very small (down to 4 nm) round-shape nanoparticles of highly pure sp3 diamond with very bright and stable photoluminescent centres.

Such a fine fabrication process can now be used for the large-scale production of fluorescent diamond nanoparticles. One can vary and tailor their properties via the composition of the starting material to answer the needs of future applications. These fluorescent diamond nanoparticles open realistic perspectives to very long term labeling, to quantitative biology and innovative nanotechnology applications in composites, optoelectronics or analytical chemistry.


'/>"/>

Contact: Patrick Curmi
pcurmi@univ-evry.fr
33-144-236-086
INSERM (Institut national de la sant et de la recherche mdicale)
Source:Eurekalert

Related biology technology :

1. Cephalon Announces Positive Results from a Pivotal Study of FENTORA in Opioid-tolerant Patients with Non-cancer Breakthrough Pain
2. NeoMatrix Announces Additional Funding for Breakthrough Breast Cancer Screening Test
3. Kingfisher Healthcare Launches Breakthrough Product in Europe
4. New technique can be breakthrough for early cancer diagnosis
5. Breakthrough research identifies how cells from pigs may cure diabetes
6. Harmonex Introduces CliniCom(TM), a Breakthrough in Psychiatric Intake and Assessment Technology
7. Medical Breakthrough ... Doctor Discovers Penetrating Carrier That Eradicates Fungus
8. H&V Introduces HVision Technology Platform to Accelerate Development of Breakthrough Products
9. Discovery Institute Bioethicist Lauds Breakthrough in Stem Cells Research that Eliminates Need for Human Cloning
10. Stem Cell Breakthrough Could End Human Embryonic Experimentation
11. Panacea Pharmaceuticals Lung Cancer Diagnostic Test, LC Detect(SM), Named One of Time Magazines Ten Biggest Medical Breakthroughs of 2007
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/11/2017)... ... October 11, 2017 , ... At its ... announced Dr. Suneel I. Sheikh, the co-founder, CEO and chief research scientist of ... been selected for membership in ARCS Alumni Hall of Fame . ASTER ...
(Date:10/11/2017)... Md. (PRWEB) , ... October 11, 2017 , ... ... digital pathology, announced today it will be hosting a Webinar titled, “Pathology is ... Advanced Pathology Associates , on digital pathology adoption best practices and how Proscia ...
(Date:10/11/2017)... ... 2017 , ... A new study published in Fertility and ... in vitro fertilization (IVF) transfer cycles. The multi-center matched cohort study ... comparing the results from the fresh and frozen transfer cohorts, the authors of ...
(Date:10/10/2017)... ... October 10, 2017 , ... For the second ... a US2020 STEM Mentoring Award. Representatives of the FirstHand program travelled to Washington, ... from US2020. , US2020’s mission is to change the trajectory of STEM education ...
Breaking Biology Technology:
(Date:3/30/2017)... March 30, 2017  On April 6-7, 2017, Sequencing.com ... Genome hackathon at Microsoft,s headquarters in ... will focus on developing health and wellness apps that ... Hack the Genome is the first hackathon for ... world,s largest companies in the genomics, tech and health ...
(Date:3/29/2017)... , March 29, 2017  higi, the health IT ... North America , today announced a ... the acquisition of EveryMove. The new investment and acquisition ... of tools to transform population health activities through the ... data. higi collects and secures data today ...
(Date:3/24/2017)... , March 24, 2017 The Controller General of ... Mr. Abdulla Algeen have received the prestigious international IAIR Award ... Continue Reading ... ... and Deputy Controller Abdulla Algeen (small picture on the right) have received ...
Breaking Biology News(10 mins):