Navigation Links
A Swiss Team Uses Transcranial MR-Guided Focused Ultrasound to Treat Patients With Functional Brain Disorders
Date:7/14/2009

TIRAT CARMEL, Israel, July 14 /PRNewswire/ -- InSightec Ltd. today announced that a team at the University Children's Hospital Zurich has completed a feasibility study testing the use of non-invasive transcranial MR-guided focused ultrasound surgery (MRgFUS) for the treatment of neuropathic pain. Ten adult patients diagnosed with chronic neuropathic pain successfully underwent non-invasive deep brain ablation surgery (central lateral thalamotomy) with transcranial MRgFUS and showed improvement in pain scores and reduction of pain medication with no adverse effects at three months follow-up. This is the first study in the world to test non-invasive transcranial focused ultrasound as a treatment modality for functional brain disorders.

"This study showed that we can perform successful operations in the depth of the brain without opening the cranium or physically penetrating the brain with medical tools, something that appeared to be unimaginable only a few years ago," said Daniel Jeanmonod, neurosurgeon at the University of Zurich. "By eliminating any physical penetration into the brain, we hope to duplicate the therapeutic effects of invasive deep brain ablation without the side effects for a wider group of patients."

Neurosurgeons currently treat patients with functional neurological disorders such as neuropathic pain or Parkinson's disease by inserting a tiny probe through the cranium and brain to reach and ablate damaged tissue.

"The more traditional invasive treatment works to alleviate pain and other symptoms, however it exposes the patient to complications, including infections, bleeding and damage to surrounding brain tissue," Dr. Jeanmonod explained. "Also, only patients whose target tissue lies in the clear path of the probe are eligible for the invasive procedure," he said.

"We now have early clinical evidence suggesting that transcranial MRgFUS provides a safe and effective way to non-invasively ablate tissue deep within the brain," said Ernst Martin, M.D., Director of the Magnetic Resonance Center at the University Children's Hospital Zurich. "While we need to monitor these patients further, we are very encouraged by the results to date and look forward to continuing our research. A non-invasive treatment that reduces the risk of infection and bleeding will fill an unmet need for many patients who currently have run out of treatment options or are unwilling to undergo invasive brain surgery because of the risks associated with it."

One patient in the study suffered nerve damage from a spinal tumor that led to severe pain and cramps in his right arm. The pain persisted for years and the patient ultimately reported depression and suicidal thoughts because of his condition. Immediately after receiving transcranial MRgFUS treatment on his brain, he reported that the pain had disappeared. A short time later he was able to resume normal activities that his neuropathic pain had prevented him from doing, such as gardening and outings in the country with his family.

The Swiss research team is planning a larger study for functional brain disorders and expands its clinical research to movement disorders, such as Parkinson's disease and tremor, and to other functional neurological disorders later this year. Additional sites in North America are also expected to initiate clinical research programs in functional brain disorders with transcranial MRgFUS later this year.

About ExAblate(R) 4000

ExAblate is the first system to use the MR guided focused ultrasound technology that combines MRI - to visualize the body anatomy, plan the treatment and monitor treatment outcome in real time - and high intensity focused ultrasound to target brain tissue non-invasively. MR thermometry allows the physician to control and adjust the treatment in real time to ensure that the targeted area is fully treated and surrounding tissue is spared. The ExAblate 4000 is a platform for a variety of transcranial indications, such as brain tumors, functional neurosurgery, stroke and targeted drug delivery.

The ExAblate(R) 2000, based on the same technology, was approved by the U.S. Food and Drug Administration in 2004 as a treatment for symptomatic uterine fibroids. 5,000 women have been treated worldwide to date. ExAblate 2000 received the European CE Mark certification for pain palliation of bone metastases in June 2007.

About InSightec

InSightec Ltd. is a privately held company owned by Elbit Imaging, General Electric, MediTech Advisors, LLC and employees. It was founded in 1999 to develop the breakthrough MR guided Focused Ultrasound technology and transform it into the next generation operating room.

Headquartered near Haifa, Israel, the company has over 160 employees and has invested more than $150 million in research, development, and clinical investigations. Its U.S. headquarters are located in Dallas, Texas. For more information, please go to:http://www.insightec.com/

For more information, read the article which appeared in the Neue Zurcher Zeitung.

            Media Contact:

        Hollister Hovey
        Lazar Partners
        +1-646-871-8482
        hhovey@lazarpartners.com


'/>"/>
SOURCE InSightec Ltd.
Copyright©2009 PR Newswire.
All rights reserved

Related biology technology :

1. Jina Ventures Advises Swiss Pharma Contract on Strategic Sale to Covance Inc
2. Covance Increases Early Clinical Footprint in Europe with Acquisition of Swiss-Based Early Clinical Development Site
3. 25 Short Films About Top-Level Research on swissinfo.ch
4. Swiss Experts Recommend QuantiFERON(R)-TB Gold for Tuberculosis Infection Screening Prior to Initiating anti-TNF-a Therapy
5. Pharmaceutical Institute Launches New E-Course Focused on Health Policy
6. Campbell Alliance Launches New Practice Area Focused on Medical Affairs
7. Concerned Shareholders of Biovail Announce - Independent Nominees for Election to Biovail Board of Directors - A Focused Commitment to Governance at Biovail
8. Pharmaceutical Institute Launches New Training Series Focused on Managed Markets Excellence
9. Biotechnology Value Fund, L.P. Calls Special Meeting of Avigen Stockholders To Remove Incumbent Directors and Elect Slate of Stockholder-Focused Nominees
10. New Publications Show Noninvasive Magnetic Resonance-Guided Focused Ultrasound to be a Potentially Safe, Effective Pain-Relieving Treatment for Bone Metastases
11. Frost & Sullivan Recognizes Martek Biosciences for Unique and Customer-Focused Strategies With Customer Value Enhancement Award
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/7/2017)... , ... October 06, 2017 ... ... in Hi-C-based genomic technologies, launched its ProxiMeta™ Hi-C metagenome deconvolution product, featuring ... kit and accompanying cloud-based bioinformatics software to perform Hi-C metagenome deconvolution using ...
(Date:10/6/2017)... ... October 06, 2017 , ... The HealthTech Venture ... sector at their fourth annual Conference where founders, investors, innovative practitioners and collaborators ... ELEVATE pitch competition showcasing early stage digital health and med tech companies. , ...
(Date:10/5/2017)... LINDA, CA (PRWEB) , ... October 05, 2017 , ... ... innovators, engineers, and scientists from around the world, is giving back to cancer research ... sold in October. , Now through October 31, shoppers can use promo code ...
(Date:10/5/2017)... ... October 05, 2017 , ... NIH has awarded ... Nanobind DNA/RNA extraction technology . Nanobind is a novel magnetic disk that ... that can be used for a wide variety of sample preparation applications. The ...
Breaking Biology Technology:
(Date:5/6/2017)... 5, 2017 RAM Group , ... new breakthrough in biometric authentication based on a ... properties to perform biometric authentication. These new sensors are ... created by Ram Group and its partners. This sensor ... supply chains and security. Ram Group is a ...
(Date:4/18/2017)... a global expert in SoC-based imaging and computing solutions, has developed ... the company,s hybrid codec technology. A demonstration utilizing TeraFaces ® , ... showcased during the upcoming Medtec Japan at Tokyo Big Sight April ... Vegas Convention Center April 24-27. ... Click here for an image of the M820 ...
(Date:4/13/2017)... According to a new market research report "Consumer ... Administration, and Authorization), Service, Authentication Type, Deployment Mode, Vertical, and Region - ... to grow from USD 14.30 Billion in 2017 to USD 31.75 Billion ... ... MarketsandMarkets Logo ...
Breaking Biology News(10 mins):