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A*Star scientists discover how to combat hospital-acquired infections and life-threatening toxins
Date:8/14/2011

If not contained, toxins released from dead cells can spread to neighboring healthy cells, resulting in rapid and widespread tissue and organ damage.

By identifying the specific host genes required for these toxins to attack the cell's protein 'factories', this study effectively singled out the attractive therapeutic targets from the entire human genome for developing antidotes that could potentially be effective against any toxins that share the same mode of action. For instance, ERGIC2 was found to be an important component of the cell's internal transport pathway that the toxins hijack to reach the cell's protein 'factories'.


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Contact: Dr. Sarah Chang KC
chang_kai_chen@a-star.edu.sg
656-826-6442
Agency for Science, Technology and Research (A*STAR), Singapore
Source:Eurekalert

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