Navigation Links
A*Star scientists discover how to combat hospital-acquired infections and life-threatening toxins
Date:8/14/2011

A team of scientists from A*STAR's Institute of Molecular and Cell Biology (IMCB) has discovered the secret recipe for 'antidotes' that could neutralize the deadly plant toxin Ricin, widely feared for its bioterrorism potential, as well as the Pseudomonas exotoxin (PE) responsible for the tens of thousands of hospital-acquired infections in immune-compromised patients all over the world. The results of this first ever genome-wide study to understand how the Ricin and PE toxins attack cells may also be useful for designing more effective antidotes against Diphtheria and Shiga-like toxins secreted by infectious strains of E. coli bacteria, such as those responsible for the recent food poisoning outbreak in Germany.

In this study, the team led by IMCB Principal Investigator, Dr Frdric Bard examined the entire human genome of about 22,000 genes to identify those genes of normal host cell processes which Ricin and PE toxins hijack in order to kill the cell. Of the several host genes identified, the team discovered one called ERGIC2 to be an attractive therapeutic target because it is not only highly essential for Ricin but also required for PE intoxication. "This means that we could potentially develop a generic antidote that is effective against the two different types of toxins by blocking ERGIC2 function," said Dr Bard.

Ricin is an extremely potent poison that can easily be purified from the widely available castor beans. Security experts say an amount roughly equivalent to half a grain of rice is enough to kill an adult, making it 1,000 times more poisonous than cyanide. There are currently no known antidotes for Ricin, and the ease of production of this tasteless, odorless plant toxin is why ricin is feared for its immense bioterrorism potential.

Hospital-acquired infections (HAIs) are a major healthcare problem affecting millions of people around the world. The U.S. Centers for Disease Control and Prevention estimates that HAIs le
'/>"/>

Contact: Dr. Sarah Chang KC
chang_kai_chen@a-star.edu.sg
656-826-6442
Agency for Science, Technology and Research (A*STAR), Singapore
Source:Eurekalert

Page: 1 2 3

Related biology technology :

1. A*STAR scientists invent the worlds only controllable molecule gear of minuscule size of 1.2nm
2. Clemson scientists put a (nano) spring in their step
3. City of Hope Helps KGI Launch New Management Training Program for Scientists
4. University of Pennsylvania scientists move optical computing closer to reality
5. Scientists grow nanonets able to snare added energy transfer
6. The National Cancer Institute Joins the Global Community of Scientists Now Using BIOMARKERcenter From Thomson Reuters
7. Scientists peel away the mystery behind golds catalytic prowess
8. SACHEM Launches 2-D HPLC e-Learning Program : New e-Learning Program Teaches Scientists How to Better Analyze and Prove Product Purity Through Greater Sensitivity and Precision in Identification of Trace Components
9. Vermillion and Stanford Scientists Receive Best Research Award From the PAD Coalition
10. Brewing better beer: Scientists determine the genomic origins of lager yeasts
11. Tengion Scientists Publish Positive Preclinical Findings With Neo-Organ Demonstrating Long-term Durability and Growth With Skeletal Maturation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... (PRWEB) August 28, 2014 Supplementing ... offering a promotion for Eppendorf Safe Lock ... to purchase the highest quality tubes at an ... ideal for customers doing chemical, medical, pharmaceutical, and ... who are not regularly able to afford Eppendorf ...
(Date:8/27/2014)... TX (PRWEB) August 27, 2014 Green ... million in Series B funding and secured Otter Capital ... investment capital will accelerate commercialization of GGI’s Agriplier™ technology, ... crop types. , “Since our first meeting, we ... to the biological product space,” said Alan Sobba, President ...
(Date:8/27/2014)... Aug. 27, 2014 Reportlinker.com announces ... available in its catalogue: Global ... http://www.reportlinker.com/p02316661/Global-Biodegradable-Packaging-Materials-Market-2014-2018.html About ... that are readily decomposed by the action ... non-degradable packaging in terms of raw materials, ...
(Date:8/27/2014)... August 27, 2014 The Global and ... study on the current state of the Trifluoroacetic Acid ... a basic overview of the industry, including definitions, applications ... domestic market analysis are provided with a focus on ... A comparison between the international and Chinese situation is ...
Breaking Biology Technology:Eppendorf Safe Lock Centrifuge Tube Promotion Now Available at Major Pipette Distributor Pipette.com 2Eppendorf Safe Lock Centrifuge Tube Promotion Now Available at Major Pipette Distributor Pipette.com 3Green & Grow Inc. Secures $6M Series B Funding from Otter Capital 2Green & Grow Inc. Secures $6M Series B Funding from Otter Capital 3Global Biodegradable Packaging Materials Market 2014-2018 2Global Biodegradable Packaging Materials Market 2014-2018 3Global Biodegradable Packaging Materials Market 2014-2018 4Global Biodegradable Packaging Materials Market 2014-2018 5Global Biodegradable Packaging Materials Market 2014-2018 6Global Biodegradable Packaging Materials Market 2014-2018 7Trifluoroacetic Acid Industry (Asia, Europe, North America, ROW) Analysis Report Now Available at ReportsnReports.com 2
... Diagnostics, a Boston-based molecular diagnostics company has ... of Registration from the Centers for Medicare ... Improvement Amendment (CLIA).  (Logo:  ... achievement of a CLIA certificate of accreditation ...
... BOONTON, N.J., March 1, 2012 Unigene Laboratories, Inc. ... and development of peptide-based therapeutics announced today that the ... and live audio webcast on Thursday, March 8, 2012 ... full-year 2011 financial results. Interested participants ...
... during IVF treatment has been shown to significantly improve the ... Pioneered by a Newcastle team of fertility experts at ... interlinked incubators provides a totally enclosed and controlled environment within ... Research published today in the journal PLoS ...
Cached Biology Technology:Berg Diagnostics Receives CLIA Certification and Launches Novel Vitamin D Assay 2Unigene to Announce Fourth Quarter and Full-Year 2011 Financial Results on March 8, 2012 2Increased fertility rate for IVF patients achieved by new equipment design 2
(Date:8/27/2014)... fishing traps are lost or abandoned each year in ... traps, which continue to catch fish, crabs, and other ... to habitat, fisheries, and the watermen who depend on ... newly published NOAA study. , The report, published in ... of its kind to examine the derelict fish trap ...
(Date:8/27/2014)... research has shown that piglets can be weaned later ... The outcome of the study at the University,s Roseworthy ... , is an important finding for pig producers. It ... of production. , "Sows don,t usually start their oestrous ... their piglets have been weaned," says Ms Alice Weaver, ...
(Date:8/27/2014)... Researchers from North Carolina State University have found that century-old ... affect a common insect pest that can weaken and kill ... studies found that scale insect populations increase on oak and ... that these pests may also increase with global warming," says ... lead author of a paper on the work. , "More ...
Breaking Biology News(10 mins):NOAA's Marine Debris Program reports on the national issue of derelict fishing traps 2Piglet weaning age no bar to litter frequency 2Museum specimens, modern cities show how an insect pest will respond to climate change 2
... published in chemistry and chemical engineering journals, researchers from ... for extracting carbon dioxide directly from the air using ... be used to supply carbon dioxide for such industrial ... recovery. But the method could later be used to ...
... Forests in the Pacific Northwest store more carbon than any ... may undermine their storage potential. A new study ... and the Climate Impacts Group at the University of Washington ... lose as much as a third of their carbon stores, ...
... 24, 2012   Synteract, Inc ., a full-service contract ... and data-monitoring: challenging roles for CRO statisticians," at the ... 2012 at 12:30 p.m., PDT. The roundtable will be ... is the largest gathering of statisticians held in North ...
Cached Biology News:Study shows economic feasibility for capturing carbon dioxide directly from the air 2Study shows economic feasibility for capturing carbon dioxide directly from the air 3Study shows economic feasibility for capturing carbon dioxide directly from the air 4Washington's forests will lose stored carbon as area burned by wildfire increases 2Washington's forests will lose stored carbon as area burned by wildfire increases 3Synteract to Host Joint Statistical Meeting Roundtable in San Diego 2Synteract to Host Joint Statistical Meeting Roundtable in San Diego 3
Human endothelial progenitor cells, For immunohistochemistry (IHC) Cell Chip with Human Peripheral Blood Dendritic Cells and EPCs...
Plasmacytoid dendritic cells, BDCA-4+, For immunohistochemistry (IHC) Cell Chip with Human Umbilical Cord Blood Dendritic Cells...
...
...
Biology Products: